More, Swati S.; Vince, Robert published the artcile< A metabolically stable tight-binding transition-state inhibitor of glyoxalase-I>, Quality Control of 77215-54-4, the main research area is glutathione analog urea isostere preparation inhibition glyoxalase I antitumor.
The design, synthesis, and enzyme kinetics evaluation of a transition-state inhibitor of glyoxalase-I is described. The union of the hydroxamic acid zinc-chelator with a urea isostere for the Glu-Cys amide bond led to a glutathione analog which retained inhibitory potency toward glyoxalase-I while possessing resistance toward γ-glutamyltranspeptidase mediated breakdown. This compound is viewed as a potential lead for the development of second-generation glyoxalase-I inhibitors wherein, the problems pertaining to metabolism and selectivity are overcome.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Quality Control of 77215-54-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics