Liu, Ruiying; Zheng, Ying; Han, Tao; Lan, Jie; He, Laixi; Shi, Jianyou published the artcile< Angiogenic Actions of Paeoniflorin on Endothelial Progenitor Cells and in Ischemic Stroke Rat Model>, Related Products of 112-63-0, the main research area is paeoniflorin neuroprotectant VEGF endothelial cell angiogenesis ischemic stroke; Angiogenesis; Biological Features; Endothelial Progenitor Cells; Ischemic Stroke; Paeoniflorin; Vascular Regeneration.
Ischemic stroke is one of the major diseases with high morbidity, mortality, and disability rate all over the world. Chinese herb-derived active components would provide valuable candidate compounds for ischemic stroke therapy. Paeoniflorin (PF) is an active ingredient from Paeoniae Radix which possesses neurovascular effect after ischemia. However, so far, few studies are reported on the efficacy and mechanism of PF from angiogenesis aspects. Results from our in vitro studies showed that the ability for proliferation, migration, and tube formation in bone marrow-derived endothelial progenitor cells (BM-EPCs) was promoted by coculturing with PF (100μM). Furthermore, to investigate the angiogenic effects of PF in vivo, we constructed an ischemic stroke model in rats and found that PF could reduce cerebral infarction, alleviate pathol. injury, and increase the secretion of pro-angiogenic factors and cerebral vascular d. after intraperitonially administration of 40 mg · kg-1 · day-1 for 14 days. Up-regulating the expression of VEGF/VEGF-R2 might be the mechanism of PF’s angiogenic action. In conclusion, the present study provides evidence that PF is an active monomer of Traditional Chinese Medicine which shows angiogenic actions on endothelial progenitor cells and in ischemic stroke rat model.
American Journal of Chinese Medicine published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
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