Kyei-Baffour, Kwaku; Mohammad, Haroon; Seleem, Mohamed N.; Dai, Mingji published the artcile< Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus>, Application of C19H34O2, the main research area is multidrug resistant MRSA Staphylococcus antibiotic aryl isonitrile.
Antibiotic resistance remains a major global public health threat that requires sustained discovery of novel antibacterial agents with unexploited scaffolds. Structure-activity relationship of the first-generation aryl isonitrile compounds we synthesized led to an initial lead mol. that informed the synthesis of a second-generation of aryl isonitriles. From this new series of 20 compounds, three analogs inhibited growth of methicillin-resistant Staphylococcus aureus (MRSA) (from 1 to 4 μM) and were safe to human keratinocytes. Compound 19, with an addnl. isonitrile group exhibited improved activity against MRSA compared to the first-generation lead compound This compound emerged as a candidate worthy of further investigation and further reinforced the importance of the isonitrile functionality in the compounds’ anti-MRSA activity. In a murine skin wound model, 19 significantly reduced the burden of MRSA, similar to the antibiotic fusidic acid. In summary, 19 was identified as a new lead aryl isonitrile compound effective against MRSA.
Bioorganic & Medicinal Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
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