Hao, Bao-Yu; Liu, Jin-Qiang; Zhang, Wei-Han; Chen, Xin-Zhi published the artcile< Chiral pool synthesis of N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine from L-malic acid>, Reference of 617-55-0, the main research area is methylaminomethylpiperidine chiral pool preparation malic acid.
A new synthetic route to N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine, key intermediate for CP-690,550, was disclosed with L-malic acid as the chiral pool starting material. The title compound was obtained in 16 steps with a total yield of 26% and >98% ee.
Bulletin of the Korean Chemical Society published new progress about Diastereoselective synthesis. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Reference of 617-55-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics