Delehouze, Claire; Comte, Arnaud; Leon-Icaza, Stephen Adonai; Cougoule, Celine; Hauteville, Marcelle; Goekjian, Peter; Bulinski, Jeannette Chloe; Dimanche-Boitrel, Marie-Therese; Meunier, Etienne; Rousselot, Morgane; Bach, Stephane published the artcile< Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death>, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is nigratine dual inhibitor necroptosis ferroptosis cell death.
Nigratine (also known as 6E11), a flavanone derivative of a plant natural product, was characterized as highly specific non-ATP competitive inhibitor of RIPK1 kinase, one of the key components of necroptotic cell death signaling. We show here that nigratine inhibited both necroptosis (induced by Tumor Necrosis Factor-α) and ferroptosis (induced by the small mols. glutamate, erastin, RSL3 or cumene hydroperoxide) with EC50 in the μM range. Taken together, our data showed that nigratine is a dual inhibitor of necroptosis and ferroptosis cell death pathways. These findings open potential new therapeutic avenues for treating complex necrosis-related diseases.
Scientific Reports published new progress about Cell death. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate.
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