Cucchiara, Federico; Ferraro, Sara; Luci, Giacomo; Bocci, Guido published the artcile< Relevant pharmacological interactions between alkylating agents and antiepileptic drugs: Preclinical and clinical data>, Electric Literature of 112-63-0, the main research area is review alkylating agent antiepileptic drug pharmacol interaction; Antiepileptic drugs; Busulfan; CYP enzymes; Cancer therapy; Cyclophosphamide; Drug-drug Interactions; Ifosfamide; Nitrosoureas; Temozolomide; Thiotepa.
A review. Seizures are relatively common in cancer patients, and co-administration of chemotherapeutic and antiepileptic drugs (AEDs) is highly probable and necessary in many cases. Nonetheless, clin. relevant interactions between chemotherapeutic drugs and AEDs are rarely summarized and pharmacol. described. These interactions can cause insufficient tumor and seizure control or lead to unforeseen toxicity. This review focused on pharmacokinetic and pharmacodynamic interactions between alkylating agents and AEDs, helping readers to make a rational choice of treatment optimization, and thus improving patients’ quality of life. As an example, phenobarbital, phenytoin, and carbamazepine, by increasing the hepatic metabolism of cyclophosphamide, ifosfamide and busulfan, yield smaller peak concentrations and a reduced area under the plasma concentration-time curve (AUC) of the prodrugs; alongside, the maximum concentration and AUC of their active products were increased with the possible onset of severe adverse drug reactions. On the other side, valproic acid, acting as histone deacetylase inhibitor, showed synergistic effects with temozolomide when tested in glioblastoma. The present review is aimed at providing evidence that may offer useful suggestions for rational pharmacol. strategies in patients with seizures symptoms undertaking alkylating agents. Firstly, clinicians should avoid the use of enzyme-inducing AEDs in combination with alkylating agents and prefer the use of AEDs, such as levetiracetam, that have a low or no impact on hepatic metabolism Secondly, a careful therapeutic drug monitoring of both alkylating agents and AEDs (and their active metabolites) is necessary to maintain therapeutic ranges and to avoid serious adverse reactions.
Pharmacological Research published new progress about Alkylating agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
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