Zhou, Yundong; Zhang, Yiling; Zong, Hong; Lu, Xinyao; Shen, Wei; Zhuge, Bin published the artcile< Chemical constituents, antibacterial activity and mechanism of Paeonia suffruticosa Andr. buds extract against Staphylococcus aureus and Escherichia coli O157:H7>, Related Products of 112-63-0, the main research area is phytochem antibacterial Paeonia bud extract Staphylococcus Escherichia; Escherichia coli O157:H7; Paeonia suffruticosa Andr. buds extract; Staphylococcus aureus; antibacterial activity; antibacterial mechanism; virulence factor.
Sixteen chem. constituents of Paeonia suffruticosa Andr. buds extract (PSABE) were identified by UHPLC-PDA-Q/TOF-MS, belonging to phenolic acids, flavonoids, monoterpene glycosides and gallotannins. PSABE exhibited significant antibacterial activity against six tested microorganisms. Particularly, it showed the most efficient antibacterial effect against Staphylococcus aureus and Escherichia coli O157:H7, which the min. inhibition concentration (MIC) and min. bactericide concentration (MBC) both were 1.56 mg/mL and 6.25 mg/mL, resp. The results showed that PSABE induced obvious alterations in membrane fatty acid composition of S. aureus and E. coli O157:H7, such as the decrease of unsaturated fatty acids, leading to the reduce of membrane fluidity. Membrane integrity was destroyed and cell morphol. was obviously changed with PSABE. Furthermore, the transcription level of virulence factors was inhibited in the presence of PSABE. These results indicated that PSABE mainly exerted antibacterial effect by damaging cell membrane and inhibiting transcription level of virulence factors.
Natural Product Research published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
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