Yin, Qi; Wen, Xiaolu; Chen, Yiwei; Gong, Xiangnan; Hu, Lin published the artcile< Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes>, Application In Synthesis of 94-02-0, the main research area is succinimidothiopentenoate tert butyl keto ester cinchona catalyst; tert butyl carboxyl tetrahydrothiophene preparation enantioselective diastereoselective.
An efficient catalytic asym. [4 + 1] reaction, which features the use of simple β-keto esters as one-carbon nucleophiles and 5-succinimidothio-pent-2-enoates as four-atom bielectrophiles, was developed in the presence of a bifunctional chiral phase-transfer catalyst. The new annulation provided a distinct protocol to access the functionalized 2-acyl-2-carboxyl tetrahydrothiophenes bearing consecutive quaternary and tertiary carbon stereocenters in high diastereoselectivities and enantioselectivities. Moreover, the prepared products could be readily transformed into the chiral 2-alkyl-2-carboxyl tetrahydrothiophenes via two steps of debenzoylation and alkylation reactions.
Organic Letters published new progress about [4+1] Cycloaddition reaction. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application In Synthesis of 94-02-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics