Wang, Lin; Xing, Xi; Zeng, Xianfeng; Jackson, S. RaElle; TeSlaa, Tara; Al-Dalahmah, Osama; Samarah, Laith Z.; Goodwin, Katharine; Yang, Lifeng; McReynolds, Melanie R.; Li, Xiaoxuan; Wolff, Jeremy J.; Rabinowitz, Joshua D.; Davidson, Shawn M. published the artcile< Spatially resolved isotope tracing reveals tissue metabolic activity>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is infusion nutrient isotope 3hydroxybutyrate hippocampus midbrain medulla thalamus metabolism.
Isotope tracing has helped to determine the metabolic activities of organs. Method to probe metabolic heterogeneity within organs are less developed. We couple stable-isotope-labeled nutrient infusion to matrix-assisted laser desorption ionization imaging mass spectrometry (iso-imaging) to quantitate metabolic activity in mammalian tissues in a spatially resolved manner. In the kidney, we visualize gluconeogenic flux and glycolytic flux in the cortex and medulla, resp. Tricarboxylic acid cycle substrate usage differs across kidney regions; glutamine and citrate are used preferentially in the cortex and fatty acids are used in the medulla. In the brain, we observe spatial gradations in carbon inputs to the tricarboxylic acid cycle and glutamate under a ketogenic diet. In a carbohydrate-rich diet, glucose predominates throughout but in a ketogenic diet, 3-hydroxybutyrate contributes most strongly in the hippocampus and least in the midbrain. Brain nitrogen sources also vary spatially; branched-chain amino acids contribute most in the midbrain, whereas ammonia contributes in the thalamus. Thus, iso-imaging can reveal the spatial organization of metabolic activity.
Nature Methods published new progress about Amino acid metabolism disorders. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics