Utaka, Masanori; Watabu, Hisashi; Higashi, Hiroshi; Sakai, Takashi; Tsuboi, Sadao; Torii, Sigeru published the artcile< Asymmetric reduction of aliphatic short- to long-chain β-keto acids by use of fermenting bakers' yeast>, COA of Formula: C5H10O3, the main research area is oxoalkanoic acid stereoselective reduction; fatty acid oxo stereoselective reduction; hydroxyalkanoic acid stereoselective preparation.
Me(CH2)nCOCH2CO2H (I, n = 0-4, 7-10, 12, 14) were reduced with fermenting bakers’ yeast to optically active Me(CH2)nCH(OH)CH2CO2H (II) isolated as their Me esters. In all cases, (R)-II acids were obtained in ≥98% enantiomeric excess (ee), except for I (n = 0), which afforded (S)-II (n = 0) in 86% ee. Inhibition of fermentation was observed for I (n = 7), but lowering of the substrate concentration was effective in decreasing the inhibition.
Journal of Organic Chemistry published new progress about Enzymic reduction, stereoselective. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, COA of Formula: C5H10O3.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics