Singh, Nidhi; Naaz, Farha; Verma, Rajesh; Singh, Shivendra; Singh, Ramendra K. published the artcile< Photophysical studies on drug conjugates of stavudine/zidovudine and 1,8-naphthalimide in different solvent systems>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is HIV stavudine zidovudine drug conjugate photophys properties antiHIV.
A number of fluorescent conjugates of popular anti-HIV drugs 2′,3′-didehydro-2′,3′-dideoxythymidine (stavudine, d4T) and 3′-azido-3′-deoxythymidine (zidovudine, AZT) with 1,8-naphthalimide were synthesized using the coupling reagent dicyclohexylcarbodiimide (DCC) in the presence of 4-dimethylaminopyridine (DMAP) and N,N-dimethylformamide (DMF) as solvent at room temperature The steady-state fluorescence measurement studies on these conjugates showed solvatochromic effect. Further, the fluorescence of drug conjugates was recorded in the presence of ions like Na+ and K+ at body level concentration of 135-145 mmol L-1 and 3.6-5.1 mmol L-1, resp., in phosphate buffer at pH 7.4 in aqueous media. It was observed that the drug conjugates did not show appreciable fluorescence quenching in presence of ions and buffer.
Asian Journal of Chemistry published new progress about Anti-HIV agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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