Ravu, Ranga Rao; Jacob, Melissa R.; Khan, Shabana I.; Wang, Mei; Cao, Liang; Agarwal, Ameeta K.; Clark, Alice M.; Li, Xing-Cong published the artcile< Synthesis and Antifungal Activity Evaluation of Phloeodictine Analogues>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phloeodictine analog preparation antifungal cytotoxicity structure activity relationship alkylation.
The phloeodictine-based 6-hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium structural moiety with an n-tetradecyl side chain at C-6 has been demonstrated to be a new antifungal template. Thirty-four new synthetic analogs with modifications of the bicyclic tetrahydropyrrolopyrimidinium skeleton and the N-1 side chain have been prepared and evaluated for in vitro antifungal activities against the clin. important fungal pathogens including Cryptococcus neoformans ATCC 90113, Candida albicans ATCC 90028, Candida glabrata ATCC 90030, Candida krusei ATCC 6258, and Aspergillus fumigatus ATCC 90906. Nineteen compounds showed antifungal activities against the aforementioned five fungal pathogens with min. inhibitory concentrations (MICs) in the range 0.88-10渭M, and all were fungicidal with min. fungicidal concentrations (MFCs) similar to the resp. MIC values. Three compounds were especially active against C. neoformans ATCC 90113 with MIC/MFC values of 1.0/1.0, 1.6/1.6, and 1.3/2.0渭M but exhibited low cytotoxicity with an IC50 > 40渭M against the mammalian Vero cells. The structure and antifungal activity relationship indicates that synthetic modifications of the phloeodictines can afford analogs with potent antifungal activity and reduced cytotoxicity, necessitating further preclin. studies of this new class of antifungal compounds
Journal of Natural Products published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics