Raiziss, George W.; Freifelder, Morris published the artcile< N1-Sulfanilylaminoalkylpyrimidines>, Application In Synthesis of 112-63-0, the main research area is .
The following pyrimidines were prepared by Benary’s method (C. A. 25, 1253): 2-amino-4-iso-Bu, m. 119°; 2-amino-4-amyl, m. 90°; 2-amino-4-ethyl-5-Me, m. 200°. Catalytic reduction of 2-amino-5-nitropyrimidine in EtOH with PtO2 at 3 atm. pressure gives 80% of 2,5-diaminopyrimidine, m. 200°. It is believed that the 2-amino-4-methyl-5-amylpyrimidine of Caldwell, Kornfeld and Donnell (C. A. 35, 6594.5) is the 2-amino-4-hexylpyrimidine of Sprague, Kissinger and Lincoln (C. A. 36, 426.4), m. 92-3°. The 2-sulfanilylamino-4-alkylpyrimidines were prepared from the corresponding pyrimidines (0.02 mol) and 0.02 mol of p-AcNHC6H4SO2Cl in 0.06 mol of C5H5N at a temperature below 60°, followed by hydrolysis of the N4-Ac derivative by refluxing in 10 volumes of 5% NaOH for 2 h.; the m. p., yield, and solubility in H2O at 37° (mg./100 cc.) are given: Me, 235-6°, 45%, 40; Et, 242°, 51%, 17.2; Pr, 212-14°, 50%, 25; iso-Bu, 232°, 40%, 10; Am, 226°, 46%, 20; hexyl, 204°, 40%, 20; 4,5-di-Me, 222°, 60%, 20; 4-ethyl-5-Me, 215°, 60%, 25; 4-Ph, 264°, 45%, 0.9; 2-sulfanilylamino-5,6,7,8-tetrahydroquinazoline (I), 247°, 50%, 2.5; 2,5-bis(sulfanilylamino)pyrimidine (II), 241-2°, 42%, 5.4. For the N4-Ac derivatives the m. p., yield and solubility at 37° (mg./100 cc.) in H2O and in urine are given: Me, 244°, 59%, 24.7, 27; Et, 274°, 76%, 0.78, 1; Pr, 258°, 82%, 0.64, 0.8; iso-Bu, 233°, 68%, 0.38, 0.825; Am, 222-3°, 84%, 0.44, 0.5; hexyl, 216°, 55%, 0.35, 0.7; 4, 5-di-Me, 272-3°, 78%, 11.25, 43.5; 4-ethyl-5-Me, 286°, 84%, 0.36, 0.65; Ph, 287°, 95%, 0.36, 0.51; I, 259°, 78%, 0.76, 0.97; II, 295° (decomposition), 56%, 0.5, 1.4. Therapeutic studies on mice infected with pneumococcus type II showed good results for the di-Me and the Me derivatives; the Et derivative showed slight therapeutic effects but the other compounds were inactive.
Journal of the American Chemical Society published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics