Kee, Choon Wee; Chan, Ke Min; Wong, Ming Wah; Tan, Choon-Hong published the artcile< Selective Bromination of sp3 C-H Bonds by Organophotoredox Catalysis>, COA of Formula: C19H34O2, the main research area is CH bond activation regioselective bromination photoredox catalyst radical cation.
Bromination of aliphatic and benzylic sp3 C-H bonds was achieved with visible light photoredox catalysis in the presence of morpholine by using a low loading of Eosin Y disodium salt, an inexpensive organic dye, as a photoredox catalyst, easy-to-handle CBr4 is the source of bromine. The light source was a low-power household lamp and the reaction was performed without the need of an inert atm. and anhydrous solvent. Preliminary exptl. and computational studies on the mechanism strongly suggested that an N-morpholino radical was responsible for the C-H activation step. It was proposed that this was a radical relay reaction, in which a longer-lived morpholine radical was generated from a CBr3 radical, which was relatively more transient, by a thermodynamically favorable reaction and addnl. evidence for the existence of such an N-radical was obtained from radical trapping experiments The strong preference of this reaction for electron-rich hydrogen atoms, and the high sensitivity to the steric environment around the C-H bond enabled bromination to occur on the relatively stronger C-H bond (as quantified by bond dissociation enthalpy) on the same mol. The potential for utilizing this reaction to achieve mild and regioselective bromination of sp3 C-H bonds in complex mols. was exemplified by the bromination of (+)-sclareolide and acetate-protected estrone.
Asian Journal of Organic Chemistry published new progress about Abstraction reaction catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics