Hu, Yu-qi; Fan, Shi-yong; Shi, Wei-guo; Zhong, Bo-hua published the artcile< Design, synthesis and preliminary evaluation of camptothecin derivatives>, Quality Control of 112-63-0, the main research area is camptothecin derivative Schiff base design synthesis antitumor.
Objective To design new camptothecin derivatives in order to discover the camptothecin derivatives of better bioavailability and higher anti-tumor activity. Methods Two series of camptothecin derivatives were designed and synthesized by introducing biocompatible carboxyl groups and the schiff base structure to investigate their antitumor activities in vitro. Results There were eleven camptothecin derivatives synthesized. All the compounds were identified by 1H-NMR and MS. Most of the derivative compounds showed much greater anti-tumor activities against SPCA-1 and MCF-79 cell lines than irinotecan in vitro. Conclusion The schiff base structure has been proved to improve the anti-tumor activity of camptothecin. The anti-tumor activity of the carboxyalkyl class target compound can be enhanced with the increased length of the fatty acid chain.
Jiefangjun Yaoxue Xuebao published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
Referemce:
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