Gaff, Jessica; Pillay, Prinisha; Cherry, Catherine; Laws, Simon M.; Price, Patricia; Kamerman, Peter published the artcile< The role of CAMKK2 polymorphisms in HIV-associated sensory neuropathy in South Africans>, COA of Formula: C19H34O2, the main research area is antiretroviral CAMKK2 gene polymorphism HIV sensory neuropathy; Antiretroviral therapy; CAMKK2; HIV-associated sensory neuropathy; Haplotypes; Polymorphisms.
Human immunodeficiency virus-associated sensory neuropathy (HIV-SN) is a common neurol. complication of HIV infection. It affected 57% of South African patients whose antiretroviral therapy (ART) included stavudine and was influenced by genotypes of the P2X-block (P2X7R, P2X4R and CAMKK2). We investigate associations between HIV-SN and P2X-block genotypes in patients who never received stavudine. An adjacent gene, ANAPC5, was included.75 HIV+ individuals were assessed using the Brief Peripheral Neuropathy Screen before treatment and after 6-8 mo on stavudine-free regimens. DNA was genotyped for 48 polymorphisms across the four genes using an OpenArray platform. Haplotypes were derived using fastPHASE. Associations with HIV-SN were assessed using bivariate and multivariate analyses. Nine individuals (12%) were diagnosed with HIV-SN prior to ART and a further 20 individuals (27%) developed HIV-SN within 6-8 mo. Five polymorphisms, rs503720*G (OR = 133) in P2X7R, rs10849861*A (OR = 5.99), rs1653586*T (OR = 67.8) and rs11065504*C (OR = 0.02) in CAMKK2, and rs2089886*A (OR = 6.68) in ANAPC5, associated with HIV-SN after adjusting for body weight, nadir CD4 T-cell counts and prior tuberculosis (model p < 0.0001, n = 69, Pseudo R2 = 0.54). Three CAMKK2 haplotypes were associated with HIV-SN (OR = 2.82, 3.42 and 6.85) after adjusting for body weight, nadir CD4 T-cell counts and prior tuberculosis (model p < 0.0005, n = 71, Pseudo R2 = 0.26). The results support a role for CAMKK2 in HIV-SN, independent of mechanisms invoked by stavudine. HIV-associated sensory neuropathy (HIV-SN) remains a clin. relevant complication of HIV infection and its treatment, affecting 38% of patients treated without neurotoxic stavudine. HIV-SN can impact an individual's ability to work and quality of life, with few effective therapeutic options, so an understanding of the underlying mechanisms would have clin. value. We confirm that CAMKK2 polymorphisms and haplotypes influence susceptibility to HIV-SN in South Africans treated without stavudine. This provides further evidence for a role for the protein encoded by CAMKK2 in the pathogenesis of HIV-SN, independent of mechanisms initiated by stavudine. Journal of the Neurological Sciences published new progress about Alleles. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics