Bazie, Wilfried Wenceslas; Some, Diane Yirgnur; Traore, Isidore Tiandiogo; Sanon, Anselme; Konate, Issouf; Tassembedo, Souleymane; Taofiki, Ajani Ousmane; Kania, Dramane; Ouedraogo, Abdoulaye; Vuylsteke, Bea; Gilbert, Caroline; Meda, Nicolas; Ouedraogo, Abdoul Salam; Nagot, Nicolas published the artcile< Immunovirological discordance among female sex workers who start antiretroviral therapy in Burkina Faso>, Electric Literature of 112-63-0, the main research area is human sex worker antiretroviral therapy immunovirol discordance; Antiretroviral therapy; Burkina Faso; Female sex workers; HIV-1; Immunovirological discordance.
In people living with HIV/AIDS (PLWHA), initiation of antiretroviral therapy (ART) leads to sustained effective suppression of viral replication and increasing CD4 + T cell count. However, a fraction of ART-treated patients still fail to reach adequate CD4 + T cell number despite a suppressed viral load (VL), and this phenomenon is defined as immunovirol. discordance (IVD). In Africa, several studies have reported immunovirol. outcomes of antiretroviral therapy, but little is known about IVD occurrence in Female sex workers (FSW). This study aimed to assess the prevalence of IVD and associated factors among a cohort of HIV infected FSW in Burkina Faso. We conducted a cohort study from Dec. 2003 to Oct. 2016. Immunovirol. discordance was defined as CD4 + T cell gain < 100 cells/μL despite a suppressed VL (VL < 1000 copies/mL) 12 mo after ART initiation. The CD4 + T cells were counted using BD FACSCount System and point of care Pima CD4 + Analyzer. HIV-1 RNA was quantified by real-time polymerase-chain-reaction assay with the use of the ABI 7000 system. We conducted a logistic regression to identify factors associated with discordant responses. Among the 123 HIV-1 infected FSW having at least 12 mo follow-up on ART, 105 (85.4%) achieved HIV-1 RNA suppression. Among the latter 25 gained less than 100 CD4 + T cells within 12 mo follow-up. The IVD rate was 23.8% (95%CI 16.04%-33.11%). After adjustment for age, WHO clin. stage and ART regimen including nucleoside/nucleotide reverse transcriptase inhibitors, only baseline CD4 + T cell count between 200 to 350 cells/μL (adjusted OR: 4.15; 95%CI 1.13-15.22) and 350 to 500 cells/μL (adjusted OR: 17.50; 95%CI 2.68-114.31) remain significantly associated with IVD occurrence. Immunovirol. discordance response was common in FSW with proportions close to those observed in the general population. A diagnosis and personalized follow-up of patients who do not achieve full immune reconstitution would make it possible to avoid complications in terms of morbidity and mortality. BMC Infectious Diseases published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
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