Bamborough, Paul; Barnett, Heather A.; Becher, Isabelle; Bird, Mark J.; Chung, Chun-wa; Craggs, Peter D.; Demont, Emmanuel H.; Diallo, Hawa; Fallon, David J.; Gordon, Laurie J.; Grandi, Paola; Hobbs, Clare I.; Hooper-Greenhill, Edward; Jones, Emma J.; Law, Robert P.; Le Gall, Armelle; Lugo, David; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Sheppard, Robert J.; Watson, Allan J. B.; Watson, Robert J. published the artcile< GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain>, HPLC of Formula: 112-63-0, the main research area is GSK6853 inhibitor BRPF1 bromodomain; BET; BRD1; BRPF1; BRPF2; BRPF3; bromodomain; chemical probe; epigenetics; inhibitor.
The BRPF (Bromodomain and PHD Finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. A selective benzimidazolone BRPF1 inhibitor showing micromolar activity in a cellular target engagement assay was recently described. Herein, we report the optimization of this series leading to the identification of a superior BRPF1 inhibitor suitable for in vivo studies.
ACS Medicinal Chemistry Letters published new progress about Antitumor agents (potential as). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
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