Agarwal, Sameer; Sasane, Santosh; Shah, Hardik A.; Pethani, Jignesh P.; Deshmukh, Prashant; Vyas, Vismit; Iyer, Pravin; Bhavsar, Harsh; Viswanathan, Kasinath; Bandyopadhyay, Debdutta; Giri, Poonam; Mahapatra, Jogeswar; Chatterjee, Abhijit; Jain, Mukul R.; Sharma, Rajiv published the artcile< Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors>, Related Products of 112-63-0, the main research area is cyanosulfoximineurea synthesis pharmacokinetics NLRP3 inflammasome IL1beta inflammation.
NLRP3 inflammasome mediated release of interleukin-1β (IL-1β) has been implicated in various diseases. In this study, rationally designed mimics of sulfonylurea moiety were investigated as NLRP3 inhibitors. Our results culminated into discovery of series of unprecedented N-cyano sulfoximineurea derivatives as potent NLRP3 inflammasome inhibitors. Compound 15 (IC50 = 7 nM) and analogs were found to be highly potent and selective NLRP3 inflammasome inhibitor with good pharmacokinetic profile. These effects translate in vivo, as 15, 29, and 34 significantly inhibit NLRP3 dependent IL-1β secretion in mice.
ACS Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.
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Ester – an overview | ScienceDirect Topics