Sheng, Lei; Hu, Fan; Yu, Hanqing; Tao, Xueyou; Jia, Rumeng; Gu, Yufeng; Chen, Lu; Kong, Hong; Miao, Chen; Fei, Wenjing; Yang, Yang; Jia, Jinhui; Zhu, Xia; He, Xueming; Hu, Liang; Ma, Jianxin; Liu, Wen-Tao; Yang, Mi published the artcile< Paeoniflorin inhibits ASK1-TF axis by up-regulating SOCS3 to alleviate radiation enteritis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is paeoniflorin antiinflammatory agent ASK1 TF SOCS3 radiation enteritis; ASK1; SOCS3; TF; paeoniflorin; radiation enteritis.
Radiation enteritis is one of the main adverse effects of radiotherapy, presenting with a poorly understood etiol. and limited options for therapy. Intestinal inflammation and ischemia are the core mechanisms of radiation enteritis. Suppressor of cytokine signaling 3 (SOCS3) is an endogenous “”inflammation brake.”” We hypothesized that paeoniflorin, a pinane monoterpene bitter glycoside, could increase SOCS3 expression to reduce inflammation and ischemia and improve enteritis in mice. Laser Doppler flowmetry was used to detect changes in intestinal blood flow. RAW264.7 and human umbilical vein endothelial cells were used to investigate the mechanism of action of paeoniflorin. It was observed that radiation caused high mortality, intestinal inflammatory responses, and low blood flow in mice. Paeoniflorin effectively alleviated intestinal atrophy, prevented thrombosis, improved radiation enteritis, and reduced mortality in mice undergoing radiotherapy. In addition, paeoniflorin increased the release of growth arrest-specific gene 6 (Gas6) and phosphorylation of the Axl receptor, subsequently inducing the expression of SOCS3 and inhibiting the expression of p-apoptosis signal-regulating kinase 1 and tissue factor in vivo and in vitro. Based on our findings, we suggest that paeoniflorin is potentially effective in alleviating radiation enteritis via the activation of the Gas6/Axl/SOCS3 axis and subsequent reduction in intestinal inflammation and ischemia.
Frontiers in Pharmacology published new progress about Analgesics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics