Rauen, H. M.; Nonhof, R. published the artcile< Pattern of anticytogenic activity of pyrimidine derivatives on Neurospora crassa>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .
The anticytogenic activity of 71 pyrimidine derivatives on N. crassa was determined in the horizontal proliferation test. Of these, the following 12 were found to meet the criteria of the Cancer Chemotherapy National Service Center; i.e., their inhibitory doses (H.D.50) were under the limit of 10 mg./ml. of culture medium: 2-ethylmercapto-4-chloro-5-carbethoxypyrimidine, 0.025; bis(4-methylpyrimidyl-2-disulfide, 0.044; 4,6-dichloropyrimidine, 0.060; 4-methylpyrimidyl-2-sulfenmorpholide, 0.086; 2-ethylmercapto-4-amino-4-carbethoxypyrimidine, 0.130; 2-ethylmercapto-4-hydroxycarbethoxypyrimidine, 0.85; 4-phenylpyrimidine ,0.200; 2,4,5,6-tetraaminopyrimidine sulfate, 0.350; 2-amino-4-chloro-6-methylpyrimidine, 0.370; 2,4-dimercaptopyrimidine, 0.400; 2-mercapto-4-methylpyrimidine-HCl, 0.500; 2-mercapto-4,6-dimethylpyrimidine, 0.550 mg. Combinations of 2 or more inhibitory materials showed additive, synergistic, or diminished effects. The possible inhibitory mechanism is discussed. Relations are shown between the structures of the compounds and their cytotoxic action.
Arzneimittel-Forschung published new progress about Neurospora crassa. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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