Pattenden, Gerald; Critcher, Douglas J.; Remuinan, Modesto published the artcile< Total synthesis of (-)-pateamine A, a novel immunosuppressive agent from Mycale sp>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is asym synthesis pateamine A Stille coupling reaction; sulfinimine chiral auxiliary beta amino ester preparation pateamine A.
A convergent synthesis of the unique thiazole-containing polyene bis-lactone pateamine A (I) isolated from the marine sponge Mycale sp is described. The synthesis features the ubiquitous Stille sp2-sp2 coupling reaction to elaborate the E,Z-diene macrolide core and the all-E polyenamine side chain in the natural product. It also highlights the scope for enantiopure sulfinimine intermediates in the synthesis of chiral β-amino ester moieties in complex structures.
Canadian Journal of Chemistry published new progress about Chiral auxiliary. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics