McClendon, Eric; Omollo, Ann O.; Valente, Edward J.; Hamme, Ashton T. II published the artcile< Oxonium ion-mediated synthesis of 4-substituted spiro-isoxazolines>, Reference of 112-63-0, the main research area is spiro isoxazoline stereoselective preparation hydroxyalkylisoxazole cyclization oxonium intermediate.
The stereoselective synthesis of 4-bromo-spiro-isoxazolines was achieved in one step through the bromination of various isoxazoles that contain a pendant alc. or carboxylic acid functional group. Isoxazole bromination leads to a bromonium ion intermediate, which opens either by neighboring oxygen lone pair electrons or by intramol. nucleophilic attack. Single X-ray crystal data provide evidence that the two contiguous stereocenters of the spiro-isoxazoline are formed by the anti intramol. attack of the nucleophile relative to bromine, since there is an anti stereochem. relationship between the spirocyclic ring oxygen and the bromine atom.
Tetrahedron Letters published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics