Malcor, Jean-Daniel; Brouillette, Yann; Graffion, Julien; Spielmann, Kim; Masurier, Nicolas; Maillard, Ludovic T.; Martinez, Jean; Lisowski, Vincent published the artcile< Synthesis and reactivity of pyrrolo[3,2-d][1,3]oxazine-2,4-dione. Access to new pyrrolo[3,2-e][1,4]diazepine-2,5-diones>, Safety of Ethyl 3-amino-1H-pyrrole-2-carboxylate, the main research area is pyrrolodiazepinedione preparation nucleophile reactivity.
A convenient synthesis of pyrrolo[3,2-d][1,3]oxazine-2,4-dione is described and its reactivity towards various nucleophiles studied. The regioselective ring opening of pyrrolo[3,2-d][1,3]oxazine-2,4-dione or its N-alkylated analog in the presence of alanine or proline afforded, resp., imidazolidinedione and 2 N-protected pyrrolo[3,2-e][1,4]diazepines in a one-pot process. In a last part of this study, an alternative route to produce a library of eight non protected pyrrolo[3,2-e][1,4]diazepine-2,5-diones is described to overcome the limited reactivity of pyrrolo[3,2-d][1,3]oxazine-2,4-dione.
Tetrahedron published new progress about Nucleophiles. 252932-48-2 belongs to class esters-buliding-blocks, and the molecular formula is C7H10N2O2, Safety of Ethyl 3-amino-1H-pyrrole-2-carboxylate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics