Larcher, Adele; Nocentini, Alessio; Supuran, Claudiu T.; Winum, Jean-Yves; van der Lee, Arie; Vasseur, Jean-Jacques; Laurencin, Danielle; Smietana, Michael published the artcile< Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors>, Application of C19H34O2, the main research area is dicarboxamide linked benzoxaborole preparation carbonic anhydrase inhibitor.
The synthesis, characterization, and biol. evaluation of a series of compounds incorporating two or three benzoxaborole moieties is reported. Three different synthetic strategies were used to explore within this series as much chem. space as possible, all starting from the 6-aminobenzoxaborole reagent: amide coupling, imine bond formation, and squarate coupling. Eleven new compounds were isolated in pure form, and single crystals were obtained for two of them. These compounds were then evaluated as carbonic anhydrase inhibitors against the cytosolic hCA I and II and the transmembrane hCA IV, IX, and XII isoforms. While the benzoxaborole scaffold has been recently introduced as a new chemotype for carbonic anhydrase inhibition, these new multivalent derivatives exhibited superior inhibitory activity against the tumor-associated isoform hCA IX. In particular, compared to monovalent 6-aminobenzoxaborole (KI = 813 nM) and 6-carboxybenzoxaborole (KI = 400 nM), derivative 2h characterized by a glutamic acid structural core and two benzoxaborole moieties was found to be more potent (KI = 64 nM) and more selective over human hCA II.
ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
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