Kostenko, Alexey A.; Kucherenko, Alexander S.; Zlotin, Sergei G. published the artcile< Recyclable C2-symmetric tertiary amine-squaramide organocatalysts: Design and application to asymmetric synthesis of γ-nitrocarbonyl compounds>, Product Details of C19H34O2, the main research area is sym tertiary amine squaramide organocatalyst preparation; gamma nitrocarbonyl compound enantioselective preparation; beta dicarbonyl compound nitroolefin Michael addition sym squaramide organocatalyst.
Simple C2-sym. chiral tertiary amines I [R = Ph, 2-pyridyl, (CH2)4; stereo = R,R or S,S] bearing squaramide fragments along with the 1,2-di-(pyridin-2-yl)ethane spacer group were synthesized. Among them, amine I [R = 2-pyridyl, stereo = S,S] efficiently catalyzed asym. additions of β-dicarbonyl compounds to nitroolefins in H2O/DCM, affording corresponding adducts II [R1 = Me, MeO, O(CH2)2O; R2 = C6H5, 2-BrC6H4, 2-furyl, etc.] in up to 99% yield and 94% ee. The developed procedure was scalable. Due to poor solubility in organic solvents and water, catalyst could be readily separated from the reaction mixture and reused without compromising enantiomeric enrichment and yield of product.
Tetrahedron published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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