Klescikova, Lucia; Dohanosova, Jana; Fischer, Robert published the artcile< 4-Bromo-2,3-dihydroisoxazoles: synthesis and application in halogen-lithium exchange reactions>, Electric Literature of 112-63-0, the main research area is nitrone phenylacetylene cyclization; dihydroisoxazole preparation bromination bromine lithium exchange electrophile; substituted dihydroisoxazole preparation.
The synthesis of novel types of 4-bromo-2,3-dihydroisoxazoles using pyridinium tribromide in the presence of base is described. Reactivity of the initial substrates and the yields depend on the substituent at C3. To demonstrate a practical scope of the 4-bromo-substituted 2,3-dihydroisoxazoles, representative 2-benzyl-4-bromo-3,5-diphenyl-2,3-dihydroisoxazole is subjected to halogen-lithium exchange reaction. The corresponding (2,3-dihydroisoxazol-4-yl)lithium reacts with three selected electrophiles to afford 4-substituted 2,3-dihydroisoxazoles I [R = Me, Bz, CH(OH)CH(CH3)2] in moderate yields.
Tetrahedron published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
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