Grundler, Verena; Gademann, Karl published the artcile< Direct Arginine Modification in Native Peptides and Application to Chemical Probe Development>, COA of Formula: C19H34O2, the main research area is arginine modification labeling peptide probe development; Chemical biology; drug mechanism of action; drug modification; peptide drugs.
An efficient method for the direct labeling of the Arg guanidinium group in native peptides is reported. This straightforward procedure allows modifying the arginine moiety in peptides with various reporter groups, such as fluorophores, biotin, etc., under mild conditions in an operationally simple procedure. The scope of this method tolerates various functionalized amino acids such as His, Ser, Trp, Tyr, Glu, etc., while the only limitations uncovered so far are restricted to cysteine and free amine residues. The utility of this late-stage diversification method was demonstrated in direct labeling of leuprolide, a clin. used drug, for distribution monitoring in Daphnia, and in labeling of microcystin, a cyanobacterial toxin.
ACS Medicinal Chemistry Letters published new progress about Biotinylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics