Booth, Paul M.; Fox, Christina M. J.; Ley, Steven V. published the artcile< Preparation of acyltetronic acids using tert-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids>, Application In Synthesis of 617-55-0, the main research area is carolate total synthesis; carlosate total synthesis; carlate total synthesis; acetothioacetate dianion alkylation; oxoalkanethioate preparation transesterification; oxoacyloxylalkanoate preparation ring closure.
Dianions of MeCOCH2C(O)SCMe3 were allylated with a variety of electrophiles at the γ-C. Treatment of the products with 2-hydroxy esters in the presence of Ag (I) salts gave transesterified acetoacetate derivs in good yields. These acetoacetates were cyclized to acyltetronic acid derivs using Bu4NF in THF at room temperature Natural products carlosic (I) carolic (II; R = Me) and carlic acids (II; R = CH2CO2H) acids were prepared this way.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics