Abramova, Tatiana V’s team published research in Bioorganic & Medicinal Chemistry in 2008-10-15 | 112-63-0

Bioorganic & Medicinal Chemistry published new progress about Dinucleotides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Abramova, Tatiana V.; Vasileva, Svetlana V.; Koroleva, Ludmila S.; Kasatkina, Nina S.; Silnikov, Vladimir N. published the artcile< Design and synthesis of dinucleotide 5'-triphosphates with expanded functionality>, Application of C19H34O2, the main research area is dinucleotide triphosphate preparation nucleoside.

The new approach to the synthesis of 5′-triphosphate derivatives of natural and modified dinucleotides with expanded functionality is reported. The strategy includes the combination of the solution phase synthesis of necessary dimers using the wide range of nucleic acids chem. methods and the subsequent introduction of the triphosphate residue. A number of the new potential substrates for the template dependent synthesis of nucleic acids with expanded functionality are obtained, namely, 5′-triphosphates of dinucleotides containing the functionally active groups in heterocyclic bases, in carbohydrate-phosphate backbone, and the groups mimicking the residues of natural amino acids. The abilities of the proposed synthetic route are also demonstrated by the synthesis of 5′-triphosphates of dinucleotides with modified carbohydrate-phosphate backbone.

Bioorganic & Medicinal Chemistry published new progress about Dinucleotides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics