Namitharan, Kayambu; Zhu, Tingshun; Cheng, Jiajia; Zheng, Pengcheng; Li, Xiangyang; Yang, Song; Song, Bao-An; Chi, Yonggui Robin published the artcile< Metal and carbene organocatalytic relay activation of alkynes for stereoselective reactions>, Synthetic Route of 112-63-0, the main research area is alkenyl oxindole spiroazetidine oxindole stereoselective preparation TMV infection inhibitor; isatin azide alkyne ketenimine cycloaddition copper heterocyclic carbene.
Transition metal and organic catalysts have established their own domains of excellence. It has been expected that merging the two unique domains should provide complimentary or unprecedented opportunities in converting simple raw materials to functional products. N-heterocyclic carbenes alone are excellent organocatalysts. When used with transition metals such as copper, N-heterocyclic carbenes are routinely practiced as strong-coordinating ligands. Combination of an N-heterocyclic carbene and copper therefore typically leads to deactivation of either or both of the two catalysts. The direct merge of copper as a metal catalyst and N-heterocyclic carbenes as an organocatalyst for relay activation of alkynes is described. The reaction involves copper-catalyzed activation of alkynes to generate ketenimine intermediates that are subsequently activated by an N-heterocyclic carbene organocatalyst for stereoselective reactions. Each of the two catalysts (copper metal catalyst and N-heterocyclic carbene organocatalyst) accomplishes its own missions in the activation steps without quenching each other.
Nature Communications published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics