Martinez-Pardo, Pablo; Lavios, Adrian; Sanz-Marco, Amparo; Vila, Carlos; Pedro, Jose R.; Blay, Gonzalo published the artcile< Enantioselective Synthesis of Functionalized Diazaspirocycles from 4-Benzylideneisoxazol-5(4H)-one Derivatives and Isocyanoacetate Esters>, Computed Properties of 112-63-0, the main research area is isocyanoacetate methylidene isoxazolone silver oxide squaramide enantioselective diastereoselective cycloaddition; spiro pyrrolidine isoxazolone preparation.
Enantioenriched spirocyclic compounds bearing three contiguous stereocenters and high functionalization were obtained through a formal [3+2] cycloaddition reaction catalyzed by a cooperative system. The spiro compounds were synthesized from 4-arylideneisoxazol-5-ones and isocyanoacetate esters using a bifunctional squaramide/Bronsted base organocatalyst derived from a Cinchona alkaloid and silver oxide as Lewis acid. This method afforded two out of the four possible diastereomers with good yields and high enantiomeric excess for both diastereomers.
Advanced Synthesis & Catalysis published new progress about [3+2] Cycloaddition reaction catalysts (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics