Hu, Jingyi; Huang, Hai; Che, Yuan; Ding, Chujie; Zhang, Lu; Wang, Yun; Hao, Haiping; Shen, Hong; Cao, Lijuan published the artcile< Qingchang Huashi Formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is qingchang huashi formula colitis gut microbiota homeostasis; Goblet cell; Gut microbiota; Qingchang Huashi formula; Ulcerative colitis.
The aim of this study was to clearly define the effect of QHF and its components, Baitouweng (PBR) and Baizhi (ADR) on treating UC. Pharmacodynamic effects of QHF and single herb were evaluated in dextran sulfate sodium (DSS) induced acute or chronic colitis mice. The colorectal tissues were used to detect levels of IL-1β, IL-6 and TNF-α by ELISA or qRT-PCR. The expression of NLRP3, Caspase 1 and IL-1β were examined by western blotting. QHF significantly inhibited colitis, protected mice from the loss of body weight and colon shorten. We verified that while ADR was responsible for QHF s effect on maintaining gut microbiota homeostasis and metabolism, PBR was more prominent in keeping crypt stem cells proliferation and colonic goblet cells function. Moreover, we demonstrated that the alleviation of colitis by QHF was associated with the restoration of gut microbiota-metabolism homeostasis, protection of intestinal epithelial barrier and regulation of NLRP3/IL-1β pathway. The finding of the present study suggested that QHF is curative in DSS-induced colitis by restoring gut microbiota-metabolism homeostasis and goblet cells function. An optimized QHF was constituted by ADR and PBR, which showed comparable efficacy on colitis to that of QHF. Our work probed out the active constitutes as well as the relevant pharmacol. mechanisms of QHF, shedding light on potential new drug combination for the treatment of IBD.
Journal of Ethnopharmacology published new progress about Animal gene, IL1B Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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