Month: October 2022

Kobayashi, Goro; Matsuda, Yoshiro; Natsuki, Reiko published the artcile< Quinolizine derivatives. VI. Synthesis and reaction of 1-cyano-2-methylthio-4H-quinolizin-4-ones>, Synthetic Route of 30095-98-8, the main research area is quinolizinone methylthio; methylthioquinolizinone; cyanomethylthioquinolizinone.

Reaction of ä¼?ä¼?-bis(methylthio)methylene-2-pyridylacetonitrile (I) and active methylene compounds R2CH2CO2R1 (II) (R1 = Me, Et; R2 = CN, CO2Me, 2-O2NC6H4, etc.) in Me2SO, in the presence of K2CO3, afforded 1-cyano-2-methylthio-4H-quinolizin-4-ones (III) with the corresponding substituent in 3-position. Reaction of some of these 3-substituted compounds with benzylamine produced 2-benzylamino-1-cyano-4H-quinolizin-4-ones. Reduction of 3(2-pyridyl) derivative of III over Raney Ni gave 1-cyano-3-(2-pyridyl)-4H-quinolizin-4-one.

Chemical & Pharmaceutical Bulletin published new progress about Cycloaddition reaction. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Synthetic Route of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhai, Shiyang; Zhang, Huimin; Chen, Rui; Wu, Jiangxia; Ai, Daiqiao; Tao, Shunming; Cai, Yike; Zhang, Ji-Quan; Wang, Ling published the artcile< Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma>, SDS of cas: 112-63-0, the main research area is hepatocellular carcinoma mTOR HDAC1 antiproliferative drug deign mol docking; HDACs; Hepatocellular carcinoma; Hybrids; mTOR.

Hepatocellular carcinoma (HCC) is a major contributor to global cancer incidence and mortality. Many pathways are involved in the development of HCC and various proteins including mTOR and HDACs have been identified as potential drug targets for HCC treatment. In the present study, two series of novel hybrid mols. targeting mTOR and HDACs were designed and synthesized based on parent inhibitors (MLN0128 and PP121 for mTOR, SAHA for HDACs) by using a fusion-type mol. hybridization strategy. In vitro antiproliferative assays demonstrated that these novel hybrids with suitable linker lengths exhibited broad cytotoxicity against various cancer cell lines, with significant activity against HepG2 cells. Notably, DI06, an MLN0128-based hybrid, exhibited antiproliferative activity against HepG2 cells with an IC50 value of 1.61渭M, which was comparable to those of both parent drugs (MLN0128, IC50 = 2.13渭M and SAHA, IC50 = 2.26渭M). In vitro enzyme inhibition assays indicated that DI06, DI07 and DI17 (PP121-based hybrid) exhibited nanomolar inhibitory activity against mTOR kinase and HDACs (e.g., HDAC1, HDAC2, HDAC3, HADC6 and HADC8). Cellular studies and western blot analyses uncovered that in HepG2 cells, DI06 and DI17 induced cell apoptosis by targeting mTOR and HDACs, blocked the cell cycle at the G0/G1 phase and suppressed cell migration. The potential binding modes of the hybrids (DI06 and DI17) with mTOR and HDACs were investigated by mol. docking. DI06 displayed better stability in rat liver microsomes than DI07 and DI17. Collectively, DI06 as a novel mTOR and HDACs inhibitor presented here warrants further investigation as a potential treatment of HCC.

European Journal of Medicinal Chemistry published new progress about Acetylated histone H3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kimura, Toshihiro; Kamata, Keigo; Mizuno, Noritaka published the artcile< Bifunctional Tungstate Catalyst for Chemical Fixation of CO2 at Atmospheric Pressure>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aromatic diamine propargylic alc carbon dioxide fixation tungstate catalyst; heterocycle cyclic urea carbonate quinazolinedione preparation reaction mechanism.

The authors report the first example of tungstate-based catalytic fixation of carbon dioxide (CO2). A simple monomeric tungstate, TBA[WO4] (TBA = n-Bu4N+) acts as a highly efficient homogeneous catalyst for chem. fixation of CO2 with aromatic diamines, 2-aminobenzonitriles, and propargylic alcs. to give urea derivatives quinazoline-2,4(1H,3H)-diones, and cyclic carbonates, resp. The 1H and 13C NMR spectra show the specific interaction of the tungsten-oxo moiety in TBA[WO4] with both CO2 and the substrate. This study also shows the importance of developing bifunctional catalysts which can activate both CO2 and a nucleophile (amines, alcs., etc.).

Angewandte Chemie, International Edition published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Erika L. Ponce A; Ochoa-Herrera, Valeria; Quintanilla, Francisco; Egas, David A.; Mora, Jose R. published the artcile< Optimization of a Gas Chromatography Methodology for Biodiesel Analysis>, Formula: C19H34O2, the main research area is fatty acid methyl ester biodiesel gas chromatog optimization transesterification.

Biodiesel from four different renewable resources was produced. An optimization of the reference methodol. by gas chromatog. was conducted based on the construction of calibration curves for each biodiesel during fatty acid Me esters (FAME) quantification. Therefore, in the proposed optimized methodol., pure com. standards are not necessary. Consequently, a reduction in the research expenses is achieved, making this methodol. a cost-effective alternative for FAME quantification. The calibration curves obtained for each biodiesel presented slope values between 0.5-0.7 and regression coefficients (R2) > 0.98 in all cases. These results were compared to those obtained by the conventional methodol. With respect to the validation of the optimized methodol., a comparison of the results obtained by this proposed methodol. and the reference one is presented. Finally, a robust and promising technique to quantify FAME present in biodiesel was successfully developed in this study.

Journal of Analytical Chemistry published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shah, Muddaser; Murad, Waheed; Ur Rehman, Najeeb; Mubin, Sidra; Al-Sabahi, Jamal Nasser; Ahmad, Manzoor; Zahoor, Muhammad; Ullah, Obaid; Waqas, Muhammad; Ullah, Saeed; Kamal, Zul; Almeer, Rafa; Bungau, Simona G.; Al-Harrasi, Ahmed published the artcile< GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach>, Synthetic Route of 112-63-0, the main research area is hexane oil scutellaria edelbergii biomedical therapy; GC-MS analysis; analgesic assay; anti-diabetics; anti-inflammatory; antibacterial activity; antioxidants.

The current study aimed to explore the crude oils obtained from the n-hexane fraction of Scutellaria edelbergii and further analyzed, for the first time, for their chem. composition, in vitro antibacterial, antifungal, antioxidant, antidiabetic, and in vivo anti-inflammatory, and analgesic activities. For the phytochem. composition, the oils proceeded to gas chromatog.-mass spectrometry (GC-MS) anal. and from the resultant chromatogram, 42 bioactive constituents were identified. Among them, the major components were linoleic acid Et ester (19.67%) followed by Et oleate (18.45%), linolenic acid Me ester (11.67%), and palmitic acid Et ester (11.01%). Tetrazolium 96-well plate MTT assay and agar-well diffusion methods were used to evaluate the isolated oil for its min. inhibitory concentrations (MIC), min. bactericidal concentration (MBC), half-maximal inhibitory concentrations (IC50), and zone of inhibitions that could determine the potential antimicrobial efficacy鈥瞫. Anti-glucosidase potential was visualized through mol. docking simulations where ten compounds of the oil were found to be the leading inhibitors of the selected enzyme based on interactions, binding energy, and binding affinity. The oil from the n-hexane fraction of S. edelbergii contained valuable bioactive constituents that can act as in vitro biol. and in vivo pharmacol. agents. However, further studies are needed to uncover individual responsible compounds of the observed biol. potentials which would be helpful in devising novel drugs.

Molecules published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Madan, Renu; Goyal, Shikha published the artcile< Temozolomide Induced Cutaneous Reaction.>, Quality Control of 112-63-0, the main research area is .

There is no abstract available for this document.

Neurology India published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shu, Xiaomin; Zhong, De; Lin, Yanmei; Qin, Xiao; Huo, Haohua published the artcile< Modular Access to Chiral ä¼?(Hetero)aryl Amines via Ni/Photoredox-Catalyzed Enantioselective Cross-Coupling>, Product Details of C19H34O2, the main research area is heterocyclic amine preparation enantioselective; alkyl benzamide aryl chloride cross coupling nickel photoredox catalyst.

A general and modular approach for the direct enantioselective ä¼?arylation of saturated azacycles and acyclic N-alkyl benzamides such as N-benzylpyrrolidine, N-benzylazepane, N-benzoylpiperidine, etc. via nickel/photoredox dual catalysis was reported. This process exploits the hydrogen atom transfer ability of photoeliminated chlorine radicals to convert azacycles to the corresponding ä¼?amino alkyl radicals, which were further coupled with ubiquitous and inexpensive (hetero)aryl chlorides such as 4-cyanobenzene, benzothiophene, 2-methoxypyrimidine, etc. These coupling reactions require no oxidants or organometallic reagents, feature feedstock starting materials, a broad substrate scope, and high enantioselectivities, and are applicable to late-stage diversification of medicinally relevant complex mols. Mechanistic studies suggest that the nickel catalyst uncommonly plays multiple roles, accomplishing chlorine radical generation, alpha-amino radical capture, cross-coupling, and asym. induction.

Journal of the American Chemical Society published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zeng, Zhaomu; Chen, Yueyue; Geng, Xiuchao; Zhang, Yuhao; Wen, Xichao; Yan, Qingyu; Wang, Tingting; Ling, Chen; Xu, Yan; Duan, Junchao; Zheng, Kebin; Sun, Zhiwei published the artcile< NcRNAs: multi-angle participation in the regulation of glioma chemotherapy resistance (review)>, Category: esters-buliding-blocks, the main research area is review glioma NcRNA temozolomide cisplatin bevacizumab chemotherapy; chemoresistance; circRNAs; gliomas; lncRNAs; miRNAs; nanomedicine.

A review. As the most common primary tumor of the central nervous system, gliomas have a high recurrence rate after surgical resection and are resistant to chemotherapy, particularly high-grade gliomas dominated by glioblastoma multiforme (GBM). The prognosis of GBM remains poor despite improvements in treatment modalities, posing a serious threat to human health. At present, although drugs such as temozolomide, cisplatin and bevacizumab, are effective in improving the overall survival of patients with GBM, most patients eventually develop drug resistance, leading to poor clin. prognosis. The development of multidrug resistance has therefore become a major obstacle to improving the effectiveness of chemotherapy for GBM. The ability to fully understand the underlying mechanisms of chemotherapy resistance and to develop novel therapeutic targets to overcome resistance is critical to improving the prognosis of patients with GBM. Of note, growing evidence indicates that a large number of abnormally expressed noncoding RNAs (ncRNAs) have a central role in glioma chemoresistance and may target various mechanisms to modulate chemosensitivity. In the present review, the roles and mol. mechanisms of ncRNAs in glioma drug resistance were systematically summarized, the potential of ncRNAs as drug resistance markers and novel therapeutic targets of glioma were discussed and prospects for glioma treatment were outlined. ncRNAs are a research direction for tumor drug resistance mechanisms and targeted therapies, which not only provides novel perspectives for reversing glioma drug resistance but may also promote the development of precision medicine for clin. diagnosis and treatment.

International Journal of Oncology published new progress about Chemosensitivity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Knudsen, Andreas D.; Krebs-Demmer, Lisanne; Bjoerge, Natascha I. D.; Elming, Marie B.; Gelpi, Marco; Sigvardsen, Per E.; Lebech, Anne-Mette; Fuchs, Andreas; Kuhl, Joergen T.; Koeber, Lars; Lundgren, Jens; Nordestgaard, Boerge G.; Kofoed, Klaus F.; Nielsen, Susanne D. published the artcile< Pericardial adipose tissue volume is independently associated with human immunodeficiency virus status and prior use of stavudine, didanosine, or indinavir>, Related Products of 112-63-0, the main research area is didanosine stavudine antiviral agent adipose tissue immunodeficiency virus infection; HIV; cardiac computed tomography; comorbidity; obesity; pericardial fat.

Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine whether human immunodeficiency virus (HIV) status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors. Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 1:1 on age and sex to uninfected controls. Pericardial adipose tissue volume was measured using cardiac computed tomog. A total of 587 PWH and 587 controls were included. Median age was 52 years, and 88% were male. Human immunodeficiency virus status was independently associated with 17 mL (95% confidence interval [CI], 10-23; P <.001) larger pericardial adipose tissue volume Larger pericardial adipose tissue volume was associated with low CD4+ nadir and prior use of stavudine, didanosine, and indinavir. Among PWH without thymidine analog or didanosine exposure, time since initiating combination antiretroviral treatment (per 5-yr use) was associated with l6 mL (95% CI, -6 to -25; P = .002) lower pericardial adipose tissue volume Human immunodeficiency virus status was independently associated with larger pericardial adipose tissue volume Severe immunodeficiency, stavudine, didanosine, and indinavir were associated with larger pericardial adipose tissue volume Persons with HIV with prior exposure to these drugs may constitute a distinct cardiovascular risk population. Journal of Infectious Diseases published new progress about Adipose tissue (pericardial). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qiu, You-Chun; Zhang, Fu-Li; Zhang, Chun-Nian published the artcile< A practical and efficient procedure for reduction of carboxylic acids and their derivatives: use of KBH4-MgCl2>, Category: esters-buliding-blocks, the main research area is carboxylic acid ester anhydride imide reduction borohydride magnesium chloride.

The use of KBH4-MgCl2 to reduce carboxylic acids and their derivatives to the corresponding alcs. or the resp. reduced products is described. Me (S)-3,4-O-isopropylidene-3,4-dihydroxybutanoate used as a reference substrate was reduced with KBH4 and MgCl2 in 1:1 mol ratio to 80 % (S)-1,2-O-isopropylidene-1,2,4-butanetriol. KBH4-LiCl gave higher yields but LiCl is more expensive than MgCl2.

Tetrahedron Letters published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics