Month: October 2022

On August 3, 2006, Sekiguchi, Yoshinori; Kuwada, Takeshi; Hayashi, Masato; Nozawa, Dai; Amada, Yuri; Shibata, Tsuyoshi; Yamamoto, Shuji; Ohta, Hiroshi; Okubo, Taketoshi; Koami, Takeshi published a patent.Related Products of 141940-37-6 The title of the patent was Preparation of 1,3-dihydro-2H-indol-2-one compounds and pyrrolidin-2-one compound fused with aromatic heterocycle as antagonists of arginine-vasopressin V1b receptor. And the patent contained the following:

The title compounds [I; ring A = each (un)substituted C6-14 aryl or aromatic heterocyclyl; P = a single bond, C1-5 alkylene; Q = each (un)substituted C6-14 aryl or aromatic heterocyclyl, Q1; RD and RE at 2 and 3 or 3 and 4 positions together form (un)substituted C1-3 alkylenedioxy, (CH2)m-O, N-(un)substituted (CH2)m-NH or NH-(CH2)m, (CH2)m-S, O-(CH2)m-S, or S-(CH2)m-S (m = 2-4); R5 = Q2, Q3, etc.; R6 = H, halo, (un)substituted HO; R7 = H, halo, (un)substituted SH; or R6 and R7 together represent oxo; R9 = each (un)substituted OH, SH or NH2; R33 = H, (un)substituted C1-5 alkyl, C3-8 cycloalkyl, C1-5 alkoxycarbonyl, C6-14 aryl, heterocyclyl; RA, RB, RC = H, halo, NO2, NH2, hydroxyamino, C1-5 alkyl, C1-5 alkoxy, C1-5 alkylthio, etc.] or pharmacol. acceptable salts thereof are prepared These compounds are highly selectively antagonistic to arginine-vasopressin V1b receptor over arginine-vasopressin V1a receptor and arginine-vasopressin V2 receptor, have high metabolic stabilities and show favorable migration into the brain and high concentrations in the plasma. They provide drugs which are efficacious against pathol. conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, they provide drugs which have a therapeutic or preventive effect on depression, anxiety, Alzheimer’s disease, Parkinson’s disease, Huntington’s chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. Thus, reductive amination of (4R)-1-((3R)-5-Chloro-3-[2-methoxy-5-(2-oxoethyl)phenyl]-1-([4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-L-prolinamide with piperidine using sodium triacetoxyborohydride in the presence of acetic acid din a mixture of THF and CHCl3 gave (+)-(4R)-1-[5-Chloro-3-[5-[2-(dimethylamino)ethyl]-2-methoxyphenyl]-1-[[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl]-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-L-prolinamide (II). II inhibited the binding of [3H](Arg8)vasopressin to human arginine vasopressin V1b, V1a, and V2 receptor with IC50 of 0.32, 102, and 5,050, nM, resp. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to phenylsulfonylindolylprolinamide preparation antagonist arginine vasopressin v1b receptor, dihydroindolone preparation antagonist arginine vasopressin v1b receptor, pyrrolidinone fused heterocycle preparation antagonist arginine vasopressin v1b receptor, depression anxiety alzheimer disease treatment dihydroindolone preparation and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 24, 1993, Gilbert, Kevin; Williams, Peter D.; Hobbs, Doug W.; Evans, Ben E.; Veber, Daniel F. published a patent.Electric Literature of 53838-27-0 The title of the patent was Preparation of hydantoin and succinimide-substituted spiroindanylcamphorsulfonyl derivatives as oxytocin and vasopressin antagonists. And the patent contained the following:

Title compounds [I; R = substituted (unsaturated) 5- or 6-membered heterocyclyl containing 1-3 of N, O, or S], were prepared as oxytocin antagonists (no data). Thus, indene in THF was treated with LiN(SiMe3)2 and then with (ClCH2CH2)2NCO2CMe3 (preparation given) to give 1′-(tert-butoxycarbonyl)spiro(indene-1,4-piperidine), which was deprotected and acylated with (+)-10-comphorsulfonyl chloride followed by oximation and reduction with H2/Raney Ni to give endo-I (R = NH2). This was treated with 4-nitrophenyl chloroformate/Et3N, then with H-His-OMe.2HCl/Et3N, and finally with NaH in EtOH to give I (R = Q). The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Electric Literature of 53838-27-0

The Article related to bicycloheptylmethylsulfonylspiroindanepiperidine oxytocin antagonist, spiroindanepiperidine bicycloheptylmethylsulfonyl preparation, preterm labor prevention spiroindenepiperidine, dysmenorrhea treatment spiroindanepiperidine, vasopressin antagonist spiroindanepiperidine, hydantoin spiroindanylcamphorsulfonyl oxytocin antagonist and other aspects.Electric Literature of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 3, 2019, Bhardwaj, Monika; Rasool, Faheem; Tatina, Madhu Babu; Mukherjee, Debaraj published an article.Computed Properties of 2873-29-2 The title of the article was Construction of Fused Oxabicyclic Scaffolds from Glycals and Styrenes via One-Pot Domino Transformations. And the article contained the following:

Glycals underwent diastereoselective cascade ring opening and cyclocondensation reactions with styrenes in the presence of TfOH in CH2Cl2 to yield arylcyclopentenofurans such as I. When either benzene or toluene was used as solvent, glycals underwent diastereoselective cascade Ferrier C-glycosylation and double Friedel-Crafts reactions with styrenes in the presence of TfOH to yield arylnaphthopyrans (oxadecalins) such as II. The mechanism of the reaction of triacetoxy-D-glucal with styrene in benzene was studied by isolation of intermediates and by determination of the deuterium kinetic isotope effect which provided evidence for the C-glycosylation as the slow step in the reaction. A mechanism for the reactions is proposed. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Computed Properties of 2873-29-2

The Article related to arylcyclopentenofuran arylnaphthopyran diastereoselective nonracemic preparation, triflic acid catalyst ring opening cyclocondensation glycosylation styrene glycal, stereoselective tandem ring opening cyclocondensation styrene glycal dichloromethane solvent, tandem ferrier glycosylation friedel crafts reaction styrene glycal arene and other aspects.Computed Properties of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiong, Chenghe; Feng, Shaojie; Qiao, Yin; Guo, Zhongwu; Gu, Guofeng published an article in 2018, the title of the article was Synthesis and Immunological Studies of Oligosaccharides that Consist of the Repeating Unit of Streptococcus pneumoniae Serotype 3 Capsular Polysaccharide.Synthetic Route of 79642-50-5 And the article contains the following content:

A highly convergent and efficient strategy was developed for the chem. synthesis of complex oligosaccharides of Streptococcus pneumoniae type 3 capsular polysaccharides that contain multiple glucuronic acid units. Once the oligo-glucosides were efficiently and stereoselectively assembled, the designated glucose units were regioselectively oxidized to glucuronic acid in one step at the final synthetic stage, which helped avoid difficult glycosylation that involved glucuronic acid. The target oligosaccharides had a free amino group at the reducing terminus and varied caps at the non-reducing terminus to enable further modification and structure-activity relationship studies. Immunol. evaluations of the oligosaccharide-tetanus toxoid conjugates showed that they elicited robust T-cell-dependent IgG antibody responses and that the sugar chain length had a major impact on their immunol. properties. In particular, the penta- and hexasaccharides were identified as promising antigens for vaccine development. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Synthetic Route of 79642-50-5

The Article related to bovine serum albumin tetanus toxoid glucuronic acid oligosaccharide preparation, structure activity igg antibody glycosylation glucuronic acid oligosaccharide, igg antibody vaccine tetanus toxoid glycosylation glucuronic acid oligosaccharide, oligosaccharide preparation immunol repeating unit streptococcus pneumoniae polysaccharide and other aspects.Synthetic Route of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 1, 2015, Lin, Wenbin; Manna, Kuntal; Zhang, Teng published a patent.Synthetic Route of 1312703-30-2 The title of the patent was Preparation of metal-organic frameworks containing nitrogen-donor ligands for efficient catalytic organic transformations. And the patent contained the following:

Metal-organic framework (MOFs) compositions based on nitrogen donor-based organic bridging ligands, including ligands based on 1,3-diketimine (NacNac), bipyridines and salicylaldimine, were synthesized and then post-synthetically metalated with metal precursors, such as complexes of first row transition metals. Metal complexes of the organic bridging ligands could also be directly incorporated into the MOFs. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asym. organic transformations. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor. For example, complex MOF [Zr6(OH)4O4L6] (bpy-UiO) (H2L = 2,2′-bipyridine-5,5′-dicarboxylic acid) is synthesized by reaction of ZrCl4 and H2L in DMF. The complex is used as catalyst for C-H borylation of arenes. Gas adsorption of the complex is measured as well. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Synthetic Route of 1312703-30-2

The Article related to transition metal oxo hydroxy bipyridinedicarboxylato complex catalyst preparation, gas adsorption transition metal oxo hydroxy bipyridinedicarboxylato complex, crystal structure transition metal oxo hydroxy bipyridinedicarboxylato complex, silylation hydrogenation catalyst transition metal oxo hydroxy bipyridinedicarboxylato complex and other aspects.Synthetic Route of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 28, 2009, Bennett, Nicholas J.; Mcinally, Thomas; Mochel, Tobias; Thom, Stephen; Tiden, Anna-Karin published a patent.Recommanded Product: 142327-44-4 The title of the patent was Preparation of pyrimidine derivatives for the treatment of various diseases. And the patent contained the following:

The title compounds I [R1 = alkyl, alkoxy, alkylthio;; R2 = II or III; R3 = H or alkyl; R4 = cycloalkyl, alkyl, alkenyl, alkynyl, etc.; X1 = O, S, NH or CH2; X2, X4 = a bond, O, S; R5, R51 = H or alkyl; R6 = (un)substituted alkyl or saturated heterocyclyl; j = 1-2; R7 = H, halo, OH, etc.; Z1 = alkylene or cycloalkylene; X3 = NR12, N(COR12), CONR12, etc.; Y1 = 0-2; Y1 = a bond, alkylene; A = monocyclic or bicyclic aryl or monocyclic or bicyclic heteroaryl containing 1-3 heteroatoms; R8 = (un)substituted alkyl; n = 0-2; R9 = halo, CN, OH, etc.; R12 = H, 3-8 membered (un)saturated heterocyclyl, alkyl, etc.], useful in the treatment of asthma, COPD, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, cancer, hepatitis B, hepatitis C, HIV, HPV, bacterial infections and dermatosis, were prepared E,g. a multi-step synthesis of IV, starting from 2-amino-4-chloro-6-methylpyrimidine and pentylamine, was given. Exemplified compounds I were tested in human TLR7 assay. For example, IV showed pEC50 of 6.3. Pharmaceutical compositions comprising the compound I, alone or in combination with other therapeutic agent, were disclosed. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Recommanded Product: 142327-44-4

The Article related to pyrimidine pyrimidinediamine preparation antiasthmatic antitumor antibacterial antiaids, copd allergic rhinitis conjunctivitis atopic dermatitis treatment pyrimidinediamine preparation, hepatitis b c hiv hpv dermatosis treatment pyrimidinediamine preparation, toll like receptor tlr 7 modulator pyrimidine pyrimidinediamine preparation and other aspects.Recommanded Product: 142327-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xue; Ling, Liang; Luo, Meiming; Zeng, Xiaoming published an article in 2019, the title of the article was Accessing Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles: Preferential Hydrogen Addition to the Substitution Sites for Dearomatization.Related Products of 141940-37-6 And the article contains the following content:

A straightforward process in which a cyclic (alkyl)(amino)carbene/Rh catalyst system facilitates preferential addition of hydrogen to substitution sites of difluoromethylated and trifluoromethylated arenes and heteroarenes, leading to dearomative reduction was reported. This strategy enabled diastereoselective synthesis of cis-difluoromethylated and cis-trifluoromethylated cycloalkanes such as I [R = 2-COMe, 4-pyrazolyl, 3-OTBS, etc.; R1 = CF2H, CF3] and saturated heterocycles, e.g. II, and even allowed formation of all-cis multi-trifluoromethylated cyclic products with a defined equatorial orientation of the di- and trifluoromethyl groups. Deuterium-labeling studies indicated that hydrogen preferentially attacked substitution sites of planar arenes, resulting in dearomatization, possibly with heterogeneous Rh as reactive species, followed by either reversible or irreversible hydrogen addition to nonsubstitution sites. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to difluoromethyl cis cycloalkane saturated heterocycle diastereoselective preparation, arene heteroarene cycloalkyl amino carbene rhodium catalyst dearomative reduction, trifluoromethyl cis cycloalkane saturated heterocycle diastereoselective preparation, heteroarene arene cycloalkyl amino carbene rhodium catalyst dearomative reduction and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 23, 2009, Hashimoto, Kazuki; Katoda, Wataru; Takahashi, Kazuhiko; Kurimoto, Ayumu published a patent.Name: Methyl 2-(3-formylphenyl)acetate The title of the patent was Preparation of adenine compounds. And the patent contained the following:

The title compounds I [A1 = (CH2)m; A2 = (CH2)n; R1 = alkyl; R2, R3 = H, alkyl; or NR2R3 = pyrrolidine, morpholine, piperidine, etc.; R4 = alkyl] are prepared by reacting (aminoalkyl)dihydropurinone derivatives with alkyl (3-formylphenyl)acetate in the presence of boron reducing agents. I are useful as pharmaceuticals (no data). Reaction of 6-amino-2-butoxy-9-(3-[(3-morpholin-4-ylpropyl)amino]propyl)-7,9-dihydro-8H-purin-8-one dimaleate with Me (3-formylphenyl)acetate in the presence of triethylamine and sodium triacetoxyborohydride gave Me (3-([[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-morpholin-4-ylpropyl)amino]methyl)phenyl)acetate. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Name: Methyl 2-(3-formylphenyl)acetate

The Article related to adenine derivative preparation pharmaceutical, aminobutoxyoxodihydropurinylpropylmorpholinylpropylaminomethylphenylacetate preparation, aminobutoxymorpholinylpropylaminopropyldihydropurinone reaction formylphenylacetate sodium triacetoxyborohydride, aminoalkyldihydropurinone derivative reaction formylphenylacetate boron reducing agent and other aspects.Name: Methyl 2-(3-formylphenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Qianjia; Prater, Matthew B.; Sigman, Matthew S. published an article in 2020, the title of the article was Enantioselective Synthesis of γ-Functionalized Cyclopentenones and β-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy.Computed Properties of 10472-24-9 And the article contains the following content:

In this report, the desymmetrization of cyclic enones under relay Heck conditions with an array of aryl boronic acids, alkenyl triflates and indole derivatives was described. This method granted facile access to diverse γ-functionalized cyclopentenones I [Ar = Ph, 2-naphthyl, benzo[d][1,3]dioxol-5-yl, 4-oxocyclopent-2-en-1-yl, etc.] and δ-functionalized cycloheptenones II [R = Ph, 4-CF3C6H4, C(Me):C(Me)CO2Et, etc.]. Using this approach, a formal synthesis of (S)-baclofen was completed in high yield and excellent enantioselectivity. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Computed Properties of 10472-24-9

The Article related to gamma functionalized cyclopentenone enantioselective preparation, cyclopentenone aryl boronic acid alkenyl triflate palladium relay heck, delta functionalized cycloheptenone enantioselective preparation, cycloheptenone aryl boronic acid alkenyl triflate palladium relay heck, asymmetric catalysis, c–c coupling, heck reaction, palladium and other aspects.Computed Properties of 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Qianjia; Prater, Matthew B.; Sigman, Matthew S. published an article in 2020, the title of the article was Enantioselective Synthesis of γ-Functionalized Cyclopentenones and β-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy.Name: 3-Acetyldihydrofuran-2(3H)-one And the article contains the following content:

In this report, the desymmetrization of cyclic enones under relay Heck conditions with an array of aryl boronic acids, alkenyl triflates and indole derivatives was described. This method granted facile access to diverse γ-functionalized cyclopentenones I [Ar = Ph, 2-naphthyl, benzo[d][1,3]dioxol-5-yl, 4-oxocyclopent-2-en-1-yl, etc.] and δ-functionalized cycloheptenones II [R = Ph, 4-CF3C6H4, C(Me):C(Me)CO2Et, etc.]. Using this approach, a formal synthesis of (S)-baclofen was completed in high yield and excellent enantioselectivity. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Name: 3-Acetyldihydrofuran-2(3H)-one

The Article related to gamma functionalized cyclopentenone enantioselective preparation, cyclopentenone aryl boronic acid alkenyl triflate palladium relay heck, delta functionalized cycloheptenone enantioselective preparation, cycloheptenone aryl boronic acid alkenyl triflate palladium relay heck, asymmetric catalysis, c–c coupling, heck reaction, palladium and other aspects.Name: 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics