Month: October 2022

Kurt, Adnan; Koca, Murat published the artcile< Synthesis, characterization and thermal degradation kinetics of pyrazole derived methacrylate polymer, poly(1,3-diphenyl-1H-pyrazol-5-Yl methacrylate)>, Application In Synthesis of 94-02-0, the main research area is polydiphenyl pyrazol methacrylate preparation thermal degradation activation energy; Pyrazole derived polymer; activation energy; reaction mechanism; synthesis and characterization; thermal degradation kinetics.

Since the behavior and properties of macromol. pyrazole derived polymers differ from their small mols., such polymers are in the class of well-defined functional polymers due to the fact that the pyrazole ring contains two π-bonds as well as two hetero atoms in its structure, and this feature makes them important in the fields of scientific and technol. applications. In present study, therefore, we synthesized a new pyrazole derived methacrylate monomer, 1,3-diphenyl-1H-pyrazol-5-yl methacrylate, from the reaction of 1,3-diphenyl-5-pyrazolone with methacryloyl chloride in the presence of triethylamine. After that, its homopolymerization was carried out by free radical polymerization method at 60°C initiated with benzoyl peroxide. Spectral characterizations were achieved by 1H-NMR and FTIR spectroscopies. The kinetics of thermal degradation of the new polymer, poly(1,3-diphenyl-1H-pyrazol-5-yl methacrylate), poly(DPPMA), were investigated by thermogravimetric anal. (TGA) at different heating rates. The initial decomposition temperature of the polymer changed from 216.3°C to 243.5°C depending on the increasing heating rate. The thermal decomposition activation energies in a conversion range of 7-19% were 79.45 kJ/mol and 81.56 kJ/mol by the Flynn-Wall-Ozawa and Kissinger methods, resp. Thermodegrdn. mechanism of the poly(DPPMA) were investigated in detail by using different kinetic methods available in the literature such as Coats-Redfern, Tang, Madhusudanan and Van Krevelen. Among all these methods, the best result was obtained for Coats-Redfern method (E = 90.93 kJ/mol) at the optimum heating rate of 15°C/min for D1 mechanism that is a one-dimensional diffusion type deceleration mechanism.

Acta Chimica Slovenica published new progress about Activation energy. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application In Synthesis of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abdel Karim, M.; Naima, E.; Sima, A. published the artcile< GC-MS Analysis and Antimicrobial Activity of Cissus quadrangularis Oil>, Formula: C19H34O2, the main research area is antimicrobial activity Cissus quadrangularis oil GC MS analysis.

This study was planned to identify and quantify the oil from Sudanese Cissus quadrangularis and to evaluate the antimicrobial activity of the extracted oil. Cissus quadrangularis is a perennial climber widely used in Sudanese ethnomedicine. This plant grows in warm tropics and may propagate through stem cutting. Cissus quadrangularis possesses digestive, anthelmintic and tonic properties. The plant is rich in ascorbic acid, calcium and carotene. It also contains flavonoids, steroids and terpenoids. GC- MS anal. of Cissus quadrangularis oil revealed the presence of the following major components: E,E,Z-1,3,12-nonadecatriene-5,14-diol (22.11%); (R)-(-)- 14-methyl-8-hexadecyn-1-ol (15.44%); trilinolein (12.17%); 9,12-octadecadienoyl chloride, (Z,Z)- (11.02%) and 9,12-octadecadienoic acid (Z,Z)-, Me ester (8.67%). The oil was evaluated for its antimicrobial activity against five standard human pathogens. It showed moderate activity against Staphylococcus aureus and Pseudomonas aeruginosa.

Pharmaceutical and Chemical Journal published new progress about Anthelmintics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Yinhua; Chan, Guo Hao; Chiba, Shunsuke published the artcile< Amide-Directed C-H Sodiation by a Sodium Hydride/Iodide Composite>, Synthetic Route of 112-63-0, the main research area is amide aryl sodium hydride iodide sodiation transformation; arene preparation; C−H activation; amides; arenes; metalation; sodium hydride.

A new protocol for amide-directed ortho and lateral C-H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds

Angewandte Chemie, International Edition published new progress about Alkali metal organometallic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (organosodium). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Qing; Fan, Liangbiao; Lu, Qiaomei; Yu, Xiaozhang; Liang, Meina; Nie, Jinfang; Li, Ningjie; Zhang, Lan published the artcile< Preparation and application of molecularly imprinted polymer solid-phase microextraction fiber for the selective analysis of auxins in tobacco>, Recommanded Product: 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate), the main research area is molecularly imprinted polymer solid phase microextraction fiber auxin tobacco; magnetic molecularly imprinted polymers; meat products; norfloxacin; veterinary medicine.

As signal mols., auxins play an important role in mediating plant growth. Due to serious interfering substances in plants, it is difficult to accurately detect auxins with traditional solid-phase extraction methods. To improve the selectivity of sample pretreatment, a novel molecularly imprinted polymer -coated solid-phase microextraction fiber, which could be coupled directly to HPLC, was prepared with indole acetic acid as template mol. for the selective extraction of auxins. The factors influencing the polymer formation, such as polymerization solvent, crosslinker, and polymerization time, were studied in detail to enhance the performance of indole acetic acid-molecularly imprinted polymer coating. The morphol. and chem. stability of this molecularly imprinted polymer-coated fiber was characterized by SEM, IR spectrometry, and thermal anal. The extraction capacity of the molecularly imprinted polymer-coated solid-phase microextraction fiber was evaluated for the selective extraction of indole acetic acid and indole-3-pyruvic acid followed by HPLC anal. The linear range for indole acetic acid and indole-3-pyruvic acid was 1-100 μg/L and their detection limit was 0.5 μg/L. The method was applied to the simultaneous determination of two auxins in two kinds of tobacco (Nicotiana tabacum L and Nicotiana rustica L) samples, with recoveries range from 82.1 to 120.6%.

Journal of Separation Science published new progress about Auxins Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Recommanded Product: 2-Ethyl-2-((methacryloyloxy)methyl)propane-1,3-diyl bis(2-methylacrylate).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ye, Lupeng; Park, Jonathan J.; Peng, Lei; Yang, Quanjun; Chow, Ryan D.; Dong, Matthew B.; Lam, Stanley Z.; Guo, Jianjian; Tang, Erting; Zhang, Yueqi; Wang, Guangchuan; Dai, Xiaoyun; Du, Yaying; Kim, Hyunu R.; Cao, Hanbing; Errami, Youssef; Clark, Paul; Bersenev, Alexey; Montgomery, Ruth R.; Chen, Sidi published the artcile< A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy>, Category: esters-buliding-blocks, the main research area is breast cancer proline metabolism CAR T therapy CRISPR; CAR-T; PRODH2; T cell CRISPR activation screen; T cell GOF screen; antitumor efficacy; dead-guide RNA; metabolism; mitochondria; proline metabolism.

Chimeric antigen receptor (CAR)-T cell-based immunotherapy for cancer and immunol. diseases has made great strides, but it still faces multiple hurdles. Finding the right mol. targets to engineer T cells toward a desired function has broad implications for the armamentarium of T cell-centered therapies. Here, we developed a dead-guide RNA (dgRNA)-based CRISPR activation screen in primary CD8+ T cells and identified gain-of-function (GOF) targets for CAR-T engineering. Targeted knockin or overexpression of a lead target, PRODH2, enhanced CAR-T-based killing and in vivo efficacy in multiple cancer models. Transcriptomics and metabolomics in CAR-T cells revealed that augmenting PRODH2 expression reshaped broad and distinct gene expression and metabolic programs. Mitochondrial, metabolic, and immunol. analyses showed that PRODH2 engineering enhances the metabolic and immune functions of CAR-T cells against cancer. Together, these findings provide a system for identification of GOF immune boosters and demonstrate PRODH2 as a target to enhance CAR-T efficacy.

Cell Metabolism published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Ccnb1i.p.1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hejmanowska, Joanna; Albrecht, Lukasz published the artcile< Organocatalytic asymmetric approach to spirocyclic tetrahydrothiophenes containing either a butenolide or an azlactone structural motif>, Quality Control of 112-63-0, the main research area is spirocyclic tetrahydrothiophene preparation enantioselective; mercaptoacetaldehyde butenolide azlactone Michael addition aldol organocatalyst.

In this manuscript a new organocatalytic approach to spirocyclic tetrahydrothiophenes bearing either a butenolide or an azlactone moiety is described. The developed methodol. is based on the cascade reactivity of 2-mercaptoacetaldehyde (generated in situ from 1,4-dithiane-2,5-diol) with α,β-unsaturated butenolides or azlactones, that consists of a thio-Michael addition followed by an intramol. aldol reaction. Chiral bases derived from cinchona alkaloids are used as a catalyst promoting the cascade and controlling its stereochem. outcome.

ARKIVOC (Gainesville, FL, United States) published new progress about Aldol addition, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Haode; Tian, Yu; Wang, Wenxuan; Jian, Zelang; Chen, Wen published the artcile< Organic Ammonium Ion Battery: A New Strategy for a Nonmetallic Ion Energy Storage System>, HPLC of Formula: 112-63-0, the main research area is ammonium battery charge carrier nonmetallic ion energy storage system; Ammonium-Ion Batteries; Electrochemistry; Organic Electrolytes; Prussian White Analogues.

Nonmetallic ammonium (NH4+) ion batteries are promising candidates for large-scale energy storage systems, which have the merit of low molar mass, sustainability, non-toxicity and non-dendrite. Herein, for the first time, we introduce the novel organic ammonium ion batteries (OAIBs). Significantly, a manganese-based Prussian white analog (noted as MnHCF) as cathode exhibits a reversible capacity of 104 mAh g-1 with 98% retention over 100 cycles. We further demonstrate the electrochem. performance of the NH4+ ion full cell, which delivers a reversible capacity of 45 mAh g-1 with a broad electrochem. window. Combining ex situ XPS, ex situ XRD results and electrochem. properties, the NH4+ ion storage mechanism of MnHCF in a non-aqueous electrolyte is clearly revealed. This work verifies the feasibility of employing NH4+ ions as charge carriers in organic energy storage systems and provides new insights for designing organic nonmetallic ion batteries with broad electrochem. windows and high energy d.

Angewandte Chemie, International Edition published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

El-Rafie, Hanaa Mohamed; Zahran, Magdy K.; Raoof, Gehan F. Abdel published the artcile< Cotton bandages finished with microcapsules of volatile organic constituents of marine macro-algae for wound healing>, Reference of 112-63-0, the main research area is Cotton bandage microcapsulevolatile organic constituent marine macroalgae wound healing; Algal volatile constituents; Cotton fabric finishing; Gas chromatography/Mass spectrometry; Marine macroalgae; Microencapsulation; Wound healing.

Microencapsulation is an innovative technique having a growing application in textile finishing. Besides, marine macroalgae contain plenty of phytoconstituents used in various fields especially textile finishing. This work imparts the property of wound healing finish to cotton fabrics producing a bandage from eco-friendly algal volatile organic constituents (VOCs). VOCs extracted from Digenea simplex, Lurencea papillosa, Galaxurea oblongata, and Turbenaria decurrens Egyptian marine macroalgae scattered along the coastline of the Red sea were 0.52, 0.9, 0.87, and 0.62% (v/w), resp. These VOCs as well as their microencapsulated (VOM) forms were finished onto cotton fabrics by a conventional pad-dry cure technique using sodium alginate (SA) as a shell wall material. The VOCs of each alga were extracted and chem. investigated using gas chromatog. coupled with mass spectrometry (GC-MS). The results indicate, in addition to the identification of 125 volatile compounds, the diversity and outstanding differences in volatile composition among the 4 algae. Wound healing activities of the finished fabrics were evaluated. VOCs microcapsules-finished (VOMF) fabrics were more effective compared to VOCs-finished (VOF) fabrics and almost comparable to mebo-ointment (standard drug)-finished (MoF) fabrics. The differences in VOCs efficiencies may be attributable to the diversity in type and amount of volatiles found in the four algae. Therefore, this is a low-cost, convenient, reproducible, and scalable way to obtain encapsulated VOCs for the application in textile wound healing.

Bioprocess and Biosystems Engineering published new progress about Acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hashimoto, Kei; Tatara, Ryoichi; Ueno, Kazuhide; Dokko, Kaoru; Watanabe, Masayoshi published the artcile< Design of polymer network and Li+ solvation enables thermally and oxidatively stable, mechanically reliable, and highly conductive polymer gel electrolyte for lithium batteries>, Application of C19H34O2, the main research area is design polymer network li solvation enables thermally oxidatively stable.

Herein, we demonstrate that design of polymer network and Li+-ion solvation enables the fabrication of thermally and oxidatively stable, mech. reliable, and highly conductive polymer gel electrolytes for lithium batteries. Polymer gel electrolytes have been used for Li-ion batteries (LIB) due to their quasi-solid natures and flexible shapes. However, they frequently suffer from the high vapor pressures of the incorporated solvents, low oxidative stabilities, and poor mech. properties. To overcome these drawbacks, we fabricated a tough gel electrolyte comprising a tetra-arm poly(ethylene glycol) (TPEG) homogeneous polymer network, in which a tetraglyme(G4)-based solvate ionic liquid (SIL) was incorporated. It was intriguing to find that the solvation of Li+ ion by oxygen atoms (within G4 and TPEG), represented as [O]/[Li], governed the thermal and oxidative stabilities of the gel electrolyte, while the homogeneous network contributed to the mech. reliability and high ionic conductivity At [O]/[Li] = 5, the TPEG-based gel electrolyte with no free solvent simultaneously exhibited high thermal (>200°C) and oxidative stabilities (>4.4 V), high stretchability, and high ionic conductivity (~1 mS cm-1 at 30°C). These favorable properties of the gel electrolyte resulted in reversible charge/discharge of a 4-V-class high-voltage cathode (LiNi0.6Mn0.2Co0.2O2, NMC622).

Journal of the Electrochemical Society published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Chuchu; Wu, Yu; Chen, Yantao; Xiong, Xilin; Li, Peng; Peng, Xiaomin; Li, Chunmou; Weng, Wenjun; Zhu, Yafeng; Zhou, Dunhua; Li, Yang published the artcile< Arsenic trioxide increases apoptosis of SK-N-BE (2) cells partially by inducing GPX4-mediated ferroptosis>, Application In Synthesis of 347174-05-4, the main research area is arsenic trioxide anticancer agent ferroptosis neuroblastoma; Arsenic trioxide; Ferroptosis; GPX4; Neuroblastoma; Quantitative proteomic analysis.

Neuroblastoma (NB) is the most common extracranial tumor in central nervous system threatening childrens health with limited therapeutic options. Arsenic trioxide (ATO) has been identified the cytotoxicity in NB cells but the potential mechanism remains unclear. In this study, we attempted to obtain some insight into the mechanisms of cell death induced by ATO in NB cells. Proteomic analyses found that ATO can affect the signaling pathway associated with ferroptosis, including the upregulation of iron absorption (FTL, FTH1, HO-1), ferritinophagy (LC3, P62, ATG7, NCOA4) and modifier of glutathione synthesis (GCLM); downregulation of glutamine synthetase (GS) and GPX4, which was the critical inhibitor of ferroptosis. Western blot anal. revealing GPX4 expression in SK-N-BE (2) cells decreased after treatment with ATO (7.3μM), resulting in a loss of GPX4 activity. Furthermore, Ferroptosis inhibitor ferrostatin-1 partially blocked ATO-induced cell death. Our study revealed that ATO may induce ferroptosis in neuroblastoma cell SK-N-BE (2) by facilitating the downregulation of GPX4, ultimately resulting in iron-dependent oxidative death.

Molecular Biology Reports published new progress about Antitumor agents. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application In Synthesis of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics