Month: October 2022

Li, Sha; Yang, Wenhan; Luo, Xian; Yao, Changsheng published the artcile< An efficient N-heterocyclic carbene (NHC)-catalyzed synthesis of polysubstituted cyclopentene>, Product Details of C19H34O2, the main research area is nitrogen heterocyclic carbene catalysis polysubstituted cyclopentene synthesis.

An one-pot, cascade assembly of polysubstituted cyclopentene was realized via the N-heterocyclic carbene (NHC)-catalyzed annulation of the in situ activated α,β-unsaturated carboxylic acid with 2-(2-oxo-2-arylethyl)malononitrile through the sequence of Michael addition, aldol condensation and decarboxylation. This method could serve as a new attractive strategy for the practical syntheses of multi-functionalized cyclopentene derivatives with broad substrate scope, readily availability of starting materials, mild reaction conditions, excellent yields and operational simplicity.

Youji Huaxue published new progress about Aldol condensation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seo, Chang-Seob; Lee, Mee-Young published the artcile< Method Development and Validation for Simultaneous Analysis of Eleven Components for Quality Control of Geumgwesingihwan Using HPLC-DAD and UPLC-MS/MS>, Electric Literature of 112-63-0, the main research area is geumgwesingihwan hplc uplc ms.

Geumgwesingihwan (GGSGH) is an oriental herbal formula made by adding Achyranthes bidentate Blume and Plantago asiatica L. to Yukmijiwhanghwan. It has been used for the treatment of edema since ancient times. The purpose of this study is to develop and validate a method for simultaneous quantification of 11 components: gallic acid (1), 5-(hydroxymethyl)furfural (2), geniposidic acid (3), morroniside (4), loganin (5), paeoniflorin (6), acteoside (7), cornuside (8), benzoic acid (9), benzoylpaeoniflorin (10), and paeonol (11), using high-performance liquid chromatog. with a diode array detector (HPLC-DAD) and ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS). Compounds 1-11 were separated on a Capcell Pak UG 80 C18 column (250 mm x 4.6 mm, 5 μm) using a mobile phase of a distilled water-acetonitrile system, both containing 0.1% formic acid. In UPLC-MS/MS, compounds 1-11 were separated on an Acquity UPLC BEH C18 column (100 mm x 2.1 mm, 1.7 μm) using a mobile phase of a distilled water-acetonitrile system containing 1.0% acetic acid. Using these methods, samples of GGSGH were determined to contain 0.13-2.87 mg/g (HPLC-DAD) and not detected-4.60 mg/g (UPLC-MS/MS) of compounds 1-11. The developed HPLC-DAD assays for simultaneous determination of all analytes were validated with respect to linearity, limits of detection and quantification, recovery, and precision. The established HPLC assay will be used to obtain basic data for quality evaluation of GGSGH and related oriental herbal formulas.

Separations published new progress about HPLC. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bonjour, Olivier; Liblikas, Ilme; Pehk, Tonis; Khai-Nghi, Truong; Rissanen, Kari; Vares, Lauri; Jannasch, Patric published the artcile< Rigid biobased polycarbonates with good processability based on a spirocyclic diol derived from citric acid>, COA of Formula: C19H34O2, the main research area is spirocyclic diol biobased polycarbonate synthesis property processability.

Introducing biobased polymers from renewable sources for use as high-performance thermoplastics with high demands on mech. rigidity, transparency, thermal stability, as well as good processability, is a significant challenge. In the present work we have designed and prepared a rigid biobased bis-spirocylic diol by di-cycloketalization of a bicyclic diketone (cis-bicyclo[3.3.0]octane-3,7-dione, obtained from citric acid) using trimethylolpropane. This spiro-diol monomer has two reactive primary hydroxyl groups and the synthesis from inexpensive biobased starting materials is straightforward and readily upscalable, involving no chromatog. purification In order to explore the usefulness of the new monomer, it was employed in melt polycondensations with diphenylcarbonate at up to 280°C to form rigid fully amorphous polycarbonates (PCs). Mol. weights (MWs) up to Mn = 28 kg mol-1 were achieved, and thermal and dynamic mech. measurements showed glass transitions up to Tg = 100°C, with no thermal decomposition until Td ∼350°C. Solvent cast films had excellent mech. flexibility and strength, as well as a high transparency with only slight coloration. Results by dynamic melt rheol. implied that the high-MW PCs had a good processability at 170°C, with a stable shear modulus over time, but started to degrade via chain scission reactions when the temperature approached 200°C. In conclusion, the present work demonstrates the straightforward preparation of the citric acid-based spiro-diol, and indicates that it is an efficient building block for the preparation of rigid biobased PCs and other condensation polymers.

Green Chemistry published new progress about Condensation polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Yaqing; Zhang, Xiaodong published the artcile< Study on synthesis of spiro[5.5]undecan-3-one>, Product Details of C19H34O2, the main research area is spiroundecanone preparation.

The title compound was prepared in 4 steps in 28.9% overall yield from cyclohexanone.

Tianjin Daxue Xuebao published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Lijun; Lung, Hong Lok; Huang, Tao; Lan, Rongfeng; Zha, Shuai; Chan, Lai Sheung; Thor, Waygen; Tsoi, Tik-Hung; Chau, Ho-Fai; Borestrom, Cecilia; Cobb, Steven L.; Tsao, Sai Wah; Bian, Zhao-Xiang; Law, Ga-Lai; Wong, Wing-Tak; Tai, William Chi-Shing; Chau, Wai Yin; Du, Yujun; Tang, Lucas Hao Xi; Chiang, Alan Kwok Shing; Middeldorp, Jaap M.; Lo, Kwok-Wai; Mak, Nai Ki; Long, Nicholas J.; Wong, Ka-Leung published the artcile< Reactivation of epstein-barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function>, COA of Formula: C19H34O2, the main research area is epstein barr virus oncolysis cancer EBNA1 zinc probe ZRL5P4; EBNA1-targeting agent; EBV-specific lytic inducer; dual-responsive fluorescent EBV probe.

Epstein-Barr nuclear antigen 1 (EBNA1) plays a vital role in the maintenance of the viral genome and is the only viral protein expressed in nearly all forms of Epstein-Barr virus (EBV) latency and EBV-associated diseases, including numerous cancer types. To our knowledge, no specific agent against EBV genes or proteins has been established to target EBV lytic reactivation. Here we report an EBNA1- and Zn2+-responsive probe (ZRL5P4) which alone could reactivate the EBV lytic cycle through specific disruption of EBNA1. We have utilized the Zn2+ chelator to further interfere with the higher order of EBNA1 self-association The bioprobe ZRL5P4 can respond independently to its interactions with Zn2+ and EBNA1 with different fluorescence changes. It can selectively enter the nuclei of EBV-pos. cells and disrupt the oligomerization and oriP-enhanced transactivation of EBNA1. ZRL5P4 can also specifically enhance Dicer1 and PML expression, mol. events which had been reported to occur after the depletion of EBNA1 expression. Importantly, we found that treatment with ZRL5P4 alone could reactivate EBV lytic induction by expressing the early and late EBV lytic genes/proteins. Lytic induction is likely mediated by disruption of EBNA1 oligomerization and the subsequent change of Dicer1 expression. Our probe ZRL5P4 is an EBV protein-specific agent that potently reactivates EBV from latency, leading to the shrinkage of EBV-pos. tumors, and our study also suggests the association of EBNA1 oligomerization with the maintenance of EBV latency.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gardiner, John M.; Bruce, Sarah E. published the artcile< Unexpected diastereoselectivity in AD of an L-proline-derived 1,1-disubstituted alkene>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is asym dihydroxylation diastereoselectivity.

Asym. dihydroxylation of the L-proline-derived 1,1-disubstituted alkene I catalyzed by either (DHQ)2PHAL or (DHQD)2PHAL unexpectedly leads to preference for the same diastereomer, both reactions proceeding with apparently matching double diastereoselectivity. In contrast, AD using the analogous (DHQ)2PYR or (DHQD)2PYR ligands leads to preferences for diastereomeric diols.

Tetrahedron Letters published new progress about Dihydroxylation catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Easmon, Johnny; Heinisch, Gottfried; Puerstinger, Gerhard; Langer, Thierry; Oesterreicher, Juergen K.; Grunicke, Hans H.; Hofmann, Johann published the artcile< Azinyl and Diazinyl Hydrazones Derived from Aryl N-Heteroaryl Ketones: Synthesis and Antiproliferative Activity>, Quality Control of 112-63-0, the main research area is azinyl hydrazone preparation antiproliferative activity; hydrazone diazinyl preparation antiproliferative activity; antiproliferative structure activity azinyl hydrazone preparation.

A series of N-heteroaryl hydrazones derived from aryl N-heteroaryl or bis-N-heteroaryl methanones was prepared in search for potential novel antitumor agents. The stereochem. of these compounds was established by NMR. Antiproliferative activity was determined in a panel of human tumor cell lines (CCRF-CEM, Burkitt’s lymphoma, HeLa, ZR-75-1, HT-29, and MEXF 276L) in vitro. Generally, the new compounds were more potent (IC50 = 0.011-0.436 μM) than the ribonucleotide reductase inhibitor hydroxyurea (IC50 = 140 μM). Most of the compounds exhibited the highest activity against Burkitt’s lymphoma with IC50 = 0.011-0.035 μM. [14C]Cytidine incorporation into DNA was quantitated for selected hydrazones as a measure of the inhibition of ribonucleotide reductase in Burkitt’s lymphoma cells. (E)-Hydrazones inhibit [14C]cytidine incorporation to a greater extent (IC50 = 0.67-5.05 μM) than the (Z)-isomers (IC50 = 7.20 to >10 μM). Principal component anal. of the IC50 values obtained for inhibition of cell proliferation revealed that the cell lines tested can be grouped into three main families showing different sensitivities toward the compounds in our series (i, CCRF-CEM, Burkitt’s lymphoma, and HeLa; ii, HT-29; and iii, MEXF 276 L).

Journal of Medicinal Chemistry published new progress about Cytotoxic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Son, Hyunjoo; Ku, Jayoung; Kim, Yoosik; Li, Sheng; Char, Kookheon published the artcile< Amine-Reactive Poly(pentafluorophenyl acrylate) Brush Platforms for Cleaner Protein Purification>, HPLC of Formula: 71195-85-2, the main research area is protein purification polymer brush polypentafluorophenyl acrylate.

Reactive pentafluorophenyl acrylate (PFPA) polymer brushes grafted on silica particles were prepared using surface-initiated reversible addition and fragmentation chain transfer polymerization The polymer brush was successfully immobilized with antibody, then used for protein separation The immunoprecipitated proteins showed successful enrichment of target protein, with reduced nonspecific background and less contamination from eluted antibodies. To further improve protein recovery, the hydrophobic poly(PFPA) brush was modified with hydrophilic poly(ethylene glycol) (PEG). The partially PEG-substituted poly(PFPA) brush showed better dispersion in aqueous solution, leading to improved antibody immobilization efficiency. By optimizing both the brush mol. weight and the degree of PEG substitution, an optimal balance between surface hydrophilicity and number of available PFP units was found, leading to efficient target protein purification This study shows that poly(PFPA) platform offers a versatile approach to prepare biomol.-activated surfaces with tunable surface property, which has potential applications in protein separation and other areas.

Biomacromolecules published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Caltagirone, Claudia; Gale, Philip A.; Hiscock, Jennifer R.; Hursthouse, Michael B.; Light, Mark E.; Tizzard, Graham J. published the artcile< 2-Amidoindole-based anion receptors>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is indolecarboxamide dimer preparation anion receptor stability constant; dihydrogen phosphate ligand indolecarboxamide.

The title compounds were obtained by a reaction of diamines [i.e., 1,5-pentanediamine, 1,3-benzenedimethanamine] with 1H-indole-2-carboxylic acid derivatives The above-mentioned product structures were confirmed by NMR, elemental anal., and IR. X-ray crystal structure elucidation reveals that N,N’-1,5-pentanediylbis[1H-indole-2-carboxamide] complexes dihydrogen phosphate ion pairs in the solid state, which are part of a continuous chain. While this receptor binds dihydrogen phosphate in a 1:1 stoichiometry in solution, N,N’-[1,3-phenylenebis(methylene)]bis[7-nitro-1H-indole-2-carboxamide] (i.e., a 7-nitroindole derivative), forms 1:2 receptor:dihydrogen phosphate complexes in DMSO-d6/0.5% water.

Supramolecular Chemistry published new progress about Amidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pastore, Carlo; D’Ambrosio, Valeria published the artcile< Intensification of processes for the production of ethyl levulinate using AlCl3·6H2O>, Category: esters-buliding-blocks, the main research area is aluminum chloride catalyst ethyl levulinate esterification thermodn property.

A process for obtaining Et levulinate through the direct esterification of levulinic acid and ethanol using AlCl3·6H2O as a catalyst was investigated. AlCl3·6H2O was very active in promoting the reaction and, the correspondent kinetic and thermodn. data were determined The reaction followed a homogeneous second-order reversible reaction model: in the temperature range of 318-348 K, Ea was 56.3 kJ·K-1·mol-1, whereas Keq was in the field 2.37-3.31. The activity of AlCl3·6H2O was comparable to that of conventional mineral acids. Besides, AlCl3·6H2O also induced a separation of phases in which Et levulinate resulted mainly (>98 wt%) dissolved into the organic upper layer, well separated by most of the co-formed water, which decanted in the bottom. The catalyst resulted wholly dissolved into the aqueous phase (>95 wt%), allowing at the end of a reaction cycle, complete recovery, and possible reuse for several runs. With the increase of the AlCl3·6H2O content (from 1 to 5 mol%), the reaction proceeded fast, and the phases’ separation improved. Such a behavior eventually results in an intensification of processes of reaction and separation of products and catalyst in a single step. The use of AlCl3·6H2O leads to a significant reduction of energy consumed for the final achievement of Et levulinate, and a simplification of line-processes can be achieved.

Energies (Basel, Switzerland) published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics