Month: October 2022

Yue, Rong; Lu, Qing; Zhou, Yikai published the artcile< A novel nitrite biosensor based on single-layer graphene nanoplatelet-protein composite film>, Category: esters-buliding-blocks, the main research area is nitrite biosensor single layer graphene nanoplatelet protein composite film.

A novel nitrite biosensor was developed through a sensing platform consisted of single-layer graphene nanoplatelet (SLGnP)-protein composite film. SLGnP with the virtues of excellent biocompatibility, conductivity and high sensitivity to the local perturbations can provide a biocompatible microenvironment for protein immobilization and a suitable electron transfer distance between electroactive centers of heme protein and electrode surface. A pair of well-defined and quasi-reversible cyclic voltammetric peaks that reflected the direct electrochem. for ferric/ferrous couple of myoglobin (Mb) was achieved at the composite film modified electrode. Field emission SEM (FESEM) and UV visible spectra (UV-vis) were utilized to characterize the composite film. The results demonstrated that the morphol. of the composite film was unique and the protein in the composite film retained its secondary structure similar to the native state. The composite film also displayed excellent electrocatalytic ability for the reduction of nitric oxide, which was applied to determine nitrite indirectly. It exhibited good electrochem. response to nitrite with a linear range from 0.05 to 2.5 mM and a detection limit of 0.01 mM.

Biosensors & Bioelectronics published new progress about Chemically modified electrodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Shu-jun; Zhang, Qing; Xiang, Yong-jing; Peng, Lan-yu; Peng, Wei; Ren, Qiang; Gao, Yong-xiang published the artcile< Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis>, Reference of 112-63-0, the main research area is GuiZhi ShaoYao ZhiMu decoction antiarthritic agent collagen induced arthritis; RANKL; Rheumatoid arthritis; osteoclast; osteoprotegerin.

Guizhi-Shaoyao-Zhimu decoction (GSZD) is commonly used to treat rheumatoid arthritis (RA), but its mechanism is unclear. To investigate the effect of GSZD on bone erosion in type II collagen (CII)-induced arthritis (CIA) in rats and to identify the underlying mechanism. The CIA model was prepared in male Wistar rats by two s.c. injections of CII, 1 mg/mL. Fifty CIA rats were randomized equally into the control group given saline daily, the pos. group given saline daily and methotrexate 0.75 mg/kg once a week, and three GSZD-treated groups gavaged daily with 800, 1600 and 3200 mg/kg of GSZD for 21 days. GSZD effects were assessed by paw volume, arthritic severity index and histopathol. Cytokine levels were determined by ELISA. The effects of GSZD on RAW264.7 cells were evaluated by receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and bone resorption assay. Expression of IκB-α and p65 was measured by Western blotting. Major components of GSZD were identified by HPLC. Arthritis index score, paw volume and bone destruction score showed that GSZD improved inflammatory symptoms and reduced joint tissue erosion (p < 0.01). GSZD decreased RANKL, and the number of osteoclasts (OCs) in joint tissues (p < 0.01) and increased osteoprotegerin levels (p < 0.01). GSZD inhibited RANKL-induced RAW264.7 differentiation and reduced bone resorption by OCs. GSZD upregulated IκB (p < 0.01) and p65 (p < 0.01) in the cytoplasm and downregulated p65 (p < 0.01) in the cell nucleus. Guizhi-Shaoyao-Zhimu decoction has an anti-RA effect, suggesting its possible use as a supplement and alternative drug therapy for RA. Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about Ankle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nurhayati; Saputra, L.; Awaluddin, A.; Kurniawan, E. published the artcile< Converting waste cooking oil to biodiesel catalyzed by NaOH-impregnated CaO derived from cockle shell (Anadara granosa)>, Quality Control of 112-63-0, the main research area is sodium hydroxide calcium oxide biodeisel waste cooking oil transesterification.

Herein, we developed an efficient and easily separable Na/CaO catalyst derived from cockle shell (Anadara granosa) for biodiesel production from waste cooking oil. Impregnation with 3 wt % of NaOH could enhance the sp. surface area and catalytic performance (>89% biodiesel yield). The effects of calcination temperature, reaction time, and stirring speed were also carefully studied. The quality of biodiesel obtained using this method mainly fulfills the requirements for biodiesel standard (ASTM D 6751).

Kinetics and Catalysis published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huertas, Raul; William Allwood, J.; Hancock, Robert D.; Stewart, Derek published the artcile< Iron and zinc bioavailability in common bean (Phaseolus vulgaris) is dependent on chemical composition and cooking method>, Application of C19H34O2, the main research area is Phaseolus genotyoe iron zinc bioavailability cooking biofortification; Bioavailability; Common bean; Domestic processing; In vitro digestion; Iron; Phaseolus vulgaris; Zinc.

The influence of genotype and domestic processing on iron and zinc bioavailability in common bean germplasm was investigated using an in vitro digestion model. Raw beans exhibited diversity in iron content (50 to >90 mg kg-1) although zinc content was similar (30-40 mg kg-1). Following preparation by different household cooking methods < 5% of the iron in raw beans was recovered in the bioavailable fraction following in vitro digestion. However, up to 20% of zinc present in dry seeds was bioavailable. A high proportion of iron and zinc in raw beans (up to 40%) was lost by leaching into cooking water when beans were prepared by boiling. Although untargeted LC/MS revealed genotype-dependent differences in grain chem., correlations between mineral bioavailability and antinutritional phytates and polyphenols were mostly insignificant. Our data highlight the need to consider losses during domestic processing and the related physicochem. traits in biofortification programs. Food Chemistry published new progress about Aldaric acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ge, Yang; Yang, Haijun; Wang, Changyuan; Meng, Qiang; Li, Lei; Sun, Huijun; Zhen, Yuhong; Liu, Kexin; Li, Yanxia; Ma, Xiaodong published the artcile< Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors: Targeted treatment of B lymphoblastic leukemia cell lines>, Quality Control of 112-63-0, the main research area is preparation phosphoryl derivative diphenylpyrimidine Bruton’s kinase inhibitor leukemia; BTK; DPPY; Inhibitor; Leukemia; Phosphoryl.

A family of phosphoryl-substituted diphenylpyrimidine derivatives (Pho-DPPYs) were synthesized and biol. evaluated as potent BTK inhibitors in this study. Compound 7b was found to markedly inhibit BTK activity at concentrations of 0.82 nmol/L, as well as to suppress the proliferations of B-cell leukemia cell lines (Ramos and Raji) expressing high levels of BTK at concentrations of 3.17 μM and 6.69 μM. Moreover, flow cytometry anal. results further indicated that 7b promoted cell apoptosis to a substantial degree. In a word, compound 7b is a promising BTK inhibitor for the treatment of B-cell lymphoblastic leukemia.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Valeev, R. F.; Davletbaev, A. M.; Talipov, R. F.; Miftakhov, M. S. published the artcile< Synthesis of a chiral building block for the C6-C9fragment of epothilones>, HPLC of Formula: 617-55-0, the main research area is dimethyl trimethylsilyl butynyl dioxolane diastereoselective epothilone preparation.

A procedure for the synthesis of 1,3-dioxolane I was developed via multistep reaction sequence starting from L-malic acid. Compound I could be employed as a chiral building block in the construction of C6-C9 fragment of epothilone analogs. Diastereoselective preparation of dimethyl[(trimethylsilyl)butynyl]dioxolane as chiral building block for epothilone analogs.

Russian Journal of Organic Chemistry published new progress about Acetalization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jovanovic, Predrag; Petkovic, Milos; Simic, Milena; Jovanovic, Milos; Tasic, Gordana; Crnogorac, Marija Djordjic; Zizak, Zeljko; Savic, Vladimir published the artcile< Stereocontrolled Synthesis of Highly Substituted trans α,β-Unsaturated Ketones with Potent Anticancer Properties from Glycals>, Quality Control of 4098-06-0, the main research area is stereocontrolled synthesis unsaturated ketone Heck ring opening glycal; anticancer unsaturated ketone.

A novel synthetic route for highly substituted conjugated ketones has been developed utilizing glycals as starting materials. The two-step process combined the Heck reaction/Lewis acid promoted ring opening to afford the products in 33-80 % overall yields and with a high level of trans stereoselectivity [e.g., I + 4-iodoanisole → II → III]. Since the products are essentially the aldols, this methodol. may be employed in some cases as an alternative synthetic route to the typical aldol condensation. Densely substituted, selectively protected conjugated ketones are synthetically attractive structures which, in our case, proved to be biol. equally appealing. Namely, they showed activity against several cancer cell lines, such as HeLa, K562, MDA-MB-453, in some instances overperforming cisplatin used as a standard

European Journal of Organic Chemistry published new progress about Antitumor agents. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Quality Control of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Jingjing; Zhang, Dongmei; Hu, Linlin; Zheng, Xiaowei; Chen, Caihong published the artcile< Paeoniflorin alleviates NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 (SIRT1) to reduce H2O2-induced endothelial cell damage>, HPLC of Formula: 112-63-0, the main research area is gestational hypertension SIRT1 paeoniflorin endothelium cell injury; Paeoniflorin; SIRT1; pregnancy hypertension; vascular endothelial cell dysfunction.

Pregnancy-induced hypertension (PIH) is a leading cause of maternal mortality. Paeoniflorin has been reported to alleviate hypertension, thus relieving the injury of target organ. This study aimed to investigate the role of paeoniflorin in PIH development by regulating SIRT1 in rats. The mean arterial pressure (MAP), urine protein and histopathol. damage of placenta in gestational hypertension rats were, resp., detected by noninvasive tail-artery pressure measuring instrument, BCA method and H&E staining. The viability of human umbilical vein endothelial cells (HUVECs) treated with paeoniflorin or/and H2O2 was observed by CCK-8 assay. SIRT1 protein expression in HUVECs treated with paeoniflorin or/and H2O2 was analyzed by Western blot. Tunel assay, wound healing assay and tube formation assay were used to detect the apoptosis, migration and tube formation of HUVECs administrated with paeoniflorin or/and H2O2 or/and EX527 (SIRT1 inhibitor). As a result, MAP, urine protein and histopathol. damage of placenta were enhanced in PIH rats, which were then alleviated by paeoniflorin. Paeoniflorin decreased the levels of sFlt-1, PlGF and VEGF in serum and placental tissues of gestational hypertension rats as well as the inflammatory response and oxidative stress. In addition, paeoniflorin promoted the expressions of SIRT1 and NO/eNOS and inhibited the production of iNOS in gestational hypertension rats to improve vascular endothelial cell injury. However, SIRT1 inhibition could suppress the protective effects of paeoniflorin on endothelial dysfunction of H2O2-induced HUVECs. In conclusion, paeoniflorin could improve gestational hypertension development by upregulating SIRT1.

Bioengineered published new progress about Cell injury. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nack, Tobias; Dinis de Oliveira, Thiago; Weber, Stefan; Schols, Dominique; Balzarini, Jan; Meier, Chris published the artcile< γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antiviral nucleoside triphosphate prodrugs d4TTP HIV delivery.

The antiviral activity of nucleoside reverse transcriptase inhibitors is often hampered by insufficient phosphorylation. Nucleoside triphosphate analogs are presented, in which the γ-phosphate was covalently modified by a non-bioreversible, lipophilic 4-alkylketobenzyl moiety. Interestingly, primer extension assays using human immunodeficiency virus reverse transcriptase (HIV-RT) and three DNA-polymerases showed a high selectivity of these γ-modified nucleoside triphosphates to act as substrates for HIV-RT, while they proved to be nonsubstrates for DNA-polymerases α, β, and γ. In contrast to d4TTP, the γ-modified d4TTPs showed a high resistance toward dephosphorylation in cell extracts A series of acyloxybenzyl-prodrugs of these γ-ketobenzyl nucleoside triphosphates was prepared The aim was the intracellular delivery of a stable γ-modified nucleoside triphosphate to increase the selectivity of such compounds to act in infected vs. noninfected cells. Delivery of γ-ketobenzyl-d4TTPs was proven in T-lymphocyte cell extracts The prodrugs were potent inhibitors of HIV-1/2 in cultures of infected CEM/0 cells and more importantly in thymidine kinase-deficient CD4+ T-cells.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Trowbridge, P. F.; Diehl, O. C. published the artcile< Halides and perhalides of pyridine>, SDS of cas: 112-63-0, the main research area is .

The range of formation with the periodides is great, C6H5N. HI.I to C5H5N.HI.I6, with the perbromides slight, and zero with the perchlorides. With the normal perhalides, increase in halogen lowers the melting point. With the normal halide, the hydrogen halide melts highest, the methyl halide lower, and the ethyl halide lowest. In the mixed perhalides, the power of displacement and the position of the halogen atoms in the molecule are points of great interest. Iodine in excess displaces bromine and chlorine completely, forming periodides from the normal bromides and chlorides. Bromine seems to displace iodine from the pyridine normal iodides and then combines with it to form a bromoiodide of a normal bromide. Bromine, on the other hand, displaces chlorine completely forming perbromides from the normal chlorides. Chlorine seems to displace both iodine and bromine at first to form normal chlorides, then it combines with the displaced halogen to form mixed perhalides, ICl, ICl3, BrCl, BrCl3, of the normal chlorides from C5H5N.HI and Cl2.

Journal of the American Chemical Society published new progress about Analysis (qual. test). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics