Month: October 2022

Park, Yuna; Maeng, Soohyun; Damdintogtokh, Tuvshinzaya; Oh, Hyejin; Bang, Minji; Bai, Jaewoo; Kim, Myung Kyum published the artcile< Microvirga splendida sp. nov., bacteria isolated from soil>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Microvirga splendida bacteria soil; Methylobacteriaceae; Microvirga; Novel species; Taxonomy.

Two bacterial strains, BT325T and BT690, were isolated from soil samples collected in Korea. Both strains were Gram stain-neg., short rod-shaped, and formed light-pink colored colonies. The 16S rRNA sequence similarity of strains BT325T and BT690 shared a sequence similarity of 99.7%. Both strains shared the highest 16S rRNA gene similarity of 98.6% with Microvirga arabica SV2184PT, followed by Microvirga ossetica V5/3 M T (98.5% and 98.2%, resp.), Microvirga soli R491T (98.3% and 98.2%, resp.), Microvirga aerilata (98.2% and 98.08%, resp.), Microvirga makkahensis (98.08% and 97.8%, resp.). Phylogenetic analyses based on 16S rRNA gene sequences revealed that strain BT325Tand BT690 were positioned in a distinct lineage within the family Methylobacteriaceae (order Rhizobiales, class Alphaproteobacteria). The genome size of strain BT325T was 5,200,315 bp and the genomic DNA G + C content was 64.3 mol%. The sole respiratory quinone of strain BT325T was Q-10 and the predominant cellular fatty acids were summed feature 3 (C16:1ω7c/C16:1ω6c) and summed feature 8 (C18:1ω7c/C18:1ω6c). The major polar lipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, and phosphatidylcholine. Polyphasic taxonomic anal. of biochem., chemotaxonomic, and phylogenetic analyses suggested that strains BT325T represents a novel bacterial species within the genus Microvirga, for which the name Microvirga splendida is proposed. The type strain of Microvirga splendida is BT325T (= KCTC 72406 T = NBRC 114847 T).

Antonie van Leeuwenhoek published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hechter, Oscar; Terada, Shigeyuki; Spitsberg, Vitaly; Nakahara, Tatsuo; Nakagawaga, S. Hase; Flouret, George published the artcile< Neurohypophyseal hormone-responsive renal adenylate cyclase. III. Relationship between affinity and intrinsic activity in neurohypophyseal hormones and structural analogs>, Synthetic Route of 112-63-0, the main research area is neurohyophyseal hormone structure activity; vasopressin receptor adenyl cyclase; oxytocin structure activity; kidney adenyl cyclase vasopressin.

Binding and adenylate cyclase [9012-42-4] activation with neurohypophyseal hormones (NHH) and synthetic analogs were examined in 2 bovine renal medullary membrane preparations The relation between binding affinity of NHH and 10 analogs (as determined by competitive binding studies with 3H-labeled 8-lysine vasopressin (I) [50-57-7] and adenylate cyclase activation) was studied in 1 membrane preparation under identical conditions where hormonal stimulation of cyclase was at steady state and binding was at (or near) equilibrium A linear relation was demonstrated between the neg. logs of peptide concentration required for half-maximal binding and for half-maximal enzyme activation (Ka). Study of adenylate cyclase activation by NHH analogs, with and without a preliminary preincubation, showed that the magnitude of enzyme stimulation achieved (percentage of Vmax relative to I) with certain low affinity analogs was increased when these peptides were assayed without preincubation (in the 0-10-min period) without significant influence on Ka. To maximize the magnitude of adenylate cyclase stimulation achieved with low affinity analogs, the relation between the apparent affinity and intrinsic activity of 30 NHH analogs was studied in a 2nd membrane, where adenylate cyclase was assayed without preincubation. It was found that the apparent affinity of NHH analogs may be decreased ∼5 orders of magnitude with only minimal (20%) reduction in intrinsic activity. With further decrease in affinity to a critical Ka value, there was an abrupt decrease in intrinsic activity so that peptides with Ka ∼ 2 × 10-4M were either weak partial agonists or competitive antagonists. The tripeptide tails of NHH were not necessary for adenylate cyclase activation. No single amino acid in the ring moieties was essential for biol. activity. Receptor-mediated enzyme activation apparently involves the cooperative interaction of multiple elements of the ring with complementary elements of the receptor, with Asn5 and Tyr2 of the peptide ring playing critical roles. Studies of [Nε-acylated Lys8]vasopressin analogs have revealed it is possible to introduce carboxyl functions in the Lys8 side chain with unexpectedly high retention of affinity. Retro-D analogs of [Gly7]deaminooxytocin and deaminotocinamide, with a free NH2 group, were weak partial agonists; N-formylation, resulting in charge removal, led to loss of agonistic activity with development of antagonistic activity. Structural differences between the bovine and porcine renal receptor have previously been established with respect to position 8 of the vasopressin mol. A 2nd species difference, involving the NH2 terminus of the peptide was also found. The NH2 terminus increased binding affinity in the porcine receptor but not in the bovine receptor where deaminopressinamide [35748-54-0] had a higher affinity than pressinamide [27759-18-8], and 1-deaminooxytocin [113-78-0] had a higher affinity than oxytocin [50-56-6].

Journal of Biological Chemistry published new progress about Cell membrane. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Yujeong; Onishi, Yoshiyuki; McPherson, Lisa; Kietrys, Anna M.; Hebenbrock, Marian; Jun, Yong Woong; Das, Ishani; Adimoolam, Shanthi; Ji, Debin; Mohsen, Michael G.; Ford, James M.; Kool, Eric T. published the artcile< Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is human mutant homolog activator preparation oxidative DNA damage repair.

Here, it is reported that selected tyrosine kinase (TK) inhibitors including nilotinib, employed clin. in the treatment of chronic myeloid leukemia, are activators of the repair enzyme Human MutT Homolog 1 (MTH1). MTH1 cleanses the oxidatively damaged cellular nucleotide pool by hydrolyzing the oxidized nucleotide 8-oxo-2′-deoxyguanosine (8-oxo-dG)TP, which is a highly mutagenic lesion when incorporated into DNA. Structural optimization of analogs of TK inhibitors resulted in compounds such as SU0448, which induces 1000 +/- 100% activation of MTH1 at 10μM and 410 +/- 60% at 5μM. The compounds are found to increase the activity of the endogenous enzyme, and at least one (SU0448) decreases levels of 8-oxo-dG in cellular DNA. The results suggest the possibility of using MTH1 activators to decrease the frequency of mutagenic nucleotides entering DNA, which may be a promising strategy to suppress tumorigenesis in individuals with elevated cancer risks.

ACS Chemical Biology published new progress about DNA base excision repair. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diantina, S.; McGill, C.; Millner, J.; Nadarajan, J.; Pritchard, H. W.; Colville, L.; Clavijo McCormick, A. published the artcile< Seed viability and fatty acid profiles of five orchid species before and after ageing>, Reference of 112-63-0, the main research area is seed viability fatty acid profile orchid species ageing; Epiphytic Dendrobium; fatty acid methyl esters (FAMEs); gas chromatography (GC); seed lipids; seed storage; terrestrial orchids.

Changes in seed lipid composition during ageing are associated with seed viability loss in many plant species. However, due to their small seed size, this has not been previously explored in orchids. We characterized and compared the seed viability and fatty acid profiles of five orchid species before and after ageing: one tropical epiphytic orchid from Indonesia (Dendrobium strebloceras), and four temperate species from New Zealand, D. cunninghamii (epiphytic), and Gastrodia cunninghamii, Pterostylis banksii and Thelymitra nervosa (terrestrial). Seeds were aged under controlled laboratory conditions (3-mo storage at 60% RH and 20°C). Seed viability was tested before and after ageing using tetrazolium chloride staining. Fatty acid Me esters from fresh and aged seeds were extracted through trans-esterification, and then analyzed using gas chromatog.-mass spectrometry. All species had high initial viability (>80%) and experienced significant viability loss after ageing. The saturated, polyunsaturated, monounsaturated and total fatty acid content decreased with ageing in all species, but this reduction was only significant for D. strebloceras, D. cunninghamii and G. cunninghamii. Our results suggest that fatty acid degradation is a typical response to ageing in orchids, albeit with species variation in magnitude, but the link between fatty acid degradation and viability was not elucidated. Pterostylis banksii exemplified this variation; it showed marked viability loss despite not having a significant reduction in its fatty acid content after ageing. More research is required to identify the effect of ageing on fatty acid composition in orchids, and its contribution to seed viability loss.

Plant Biology (Berlin, Germany) published new progress about Aging, plant. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Wei; Zhang, Xing-Guo published the artcile< Organophosphine-free copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur>, Synthetic Route of 19241-24-8, the main research area is primary amine sodium bromodifluoroacetate sulfur copper iodide catalyst isothiocyanation; isothiocyanate preparation green chem.

A copper-catalyzed isothiocyanation of amines with sodium bromodifluoroacetate and sulfur in the absence of organophosphine was established. This approach represented a simple and efficient one-pot synthesis of isothiocyanates and features excellent functional group tolerance and the use of a cheap, safe and odorless sulfur source. This process could directly provided isothiocyanate analogous bioactive mols., thiocarbonyl-containing pesticides and facile construction of benzoxazole and benzimidazole frames.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyanation (isothio). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Synthetic Route of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wozniak, Marian; Roszkiewicz, Witold published the artcile< Spectral data of substituted naphthyridines. V. The IR spectra of substituted 1,8-naphthyridines>, Computed Properties of 112-63-0, the main research area is IR naphthyridine derivative.

In general the IR spectra of 1,8-naphthyridines show a ring bending (skeletal) vibration at 690-740-cm-1, three adjacent H absorption at 750-795 and 810-885 cm-1, two adjacent H absorptions at 785-855 cm-1 and isolated H absorptions at 795-810 and 885-920 cm-1.

Zeszyty Naukowe Uniwersytetu Jagiellonskiego, Prace Chemiczne published new progress about IR spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahad, Abdul; Shakeel, Faiyaz; Raish, Mohammad; Ahmad, Ajaz; Bin Jardan, Yousef A.; Al-Jenoobi, Fahad I.; Al-Mohizea, Abdullah M. published the artcile< Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical Solvents>, Quality Control of 112-63-0, the main research area is temozolomide polyethylene glycol 400 thermodn solubility temperature; Apelblat and Van’t Hoff models; solubility; solution thermodynamics; temozolomide.

The solubility parameters, and solution thermodn. of temozolomide (TMZ) in 10 frequently used solvents were examined at five different temperatures The maximum mole fraction solubility of TMZ was ascertained in DMSO (1.35 x 10-2), followed by that in polyethylene glycol-400 (3.32 x 10-3) > Transcutol (2.89 x 10-3) > ethylene glycol (1.64 x 10-3) > propylene glycol (1.47 x 10-3) > H2O (7.70 x 10-4) > Et acetate (5.44 x 10-4) > ethanol (1.80 x 10-4) > iso-Pr alc. (1.32 x 10-4) > 1-butanol (1.07 x 10-4) at 323.2 K. An analogous pattern was also observed for the other investigated temperatures The quantitated TMZ solubility values were regressed using Apelblat and Van’t Hoff models and showed overall deviances of 0.96% and 1.33%, resp. Apparent thermodn. anal. indicated endothermic, spontaneous, and entropy-driven dissolution of TMZ in all solvents. TMZ solubility data may help to formulate dosage forms, recrystallize, purify, and extract/sep. TMZ.

Molecules published new progress about Dissolution. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yiliu; Turunen, Petri; de Waal, Bas F. M.; Blank, Kerstin G.; Rowan, Alan E.; Palmans, Anja R. A.; Meijer, E. W. published the artcile< Catalytic single-chain polymeric nanoparticles at work: from ensemble towards single-particle kinetics>, Computed Properties of 71195-85-2, the main research area is catalytic single chain polymeric nanoparticle design preparation.

Folding a single polymer chain around catalytically active sites to construct catalytic single chain polymeric nanoparticles (SCPNs) is a novel approach to mimic the activity and selectivity of enzymes. In order to relate the efficiency of SCPNs to their three-dimensional structure, a better understanding of their catalytic activity at an individual level, rather than at an ensemble level, is highly desirable. In this work, we present the design and preparation of catalytic SCPNs and a family of fluorogenic substrates, their characterization at the ensemble level as well as our progress toward analyzing individual SCPNs with single-mol. fluorescence microscopy. Firstly, organocopper-based SCPNs together with rhodamine-based fluorogenic substrates were designed and synthesized. The SCPNs catalyze the carbamate cleavage reaction of mono-protected rhodamines, with the dimethylpropargyloxycarbonyl protecting group being cleaved most efficiently. A systematic study focusing on the conditions during catalysis revealed that the ligand acceleration effect as well as the accumulation of substrates and catalytically active sites in SCPNs significantly promote their catalytic performance. Secondly, a streptavidin-biotin based strategy was developed to immobilize the catalytic SCPNs on the surface of glass coverslips. Fluorescence correlation spectroscopy experiments confirmed that the SCPNs remained catalytically active after surface immobilization. Finally, single-SCPN activity measurements were performed. The results qual. indicated that fluorescent product mols. were formed as a result of the catalytic reaction and that individual fluorescent product mols. could be detected. So far, no evidence for strongly different behaviors has been observed when comparing individual SCPNs.

Molecular Systems Design & Engineering published new progress about Catalysts. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Computed Properties of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Canella Vieira, Bruno; Sousa Alves, Guilherme; Vukoja, Barbara; Velho, Vinicius; Zaric, Milos; Houston, Trenton W.; Fritz, Bradley K.; Kruger, Greg R. published the artcile< Spray drift potential of dicamba plus S-metolachlor formulations>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is S metolachlor Amaranthus formulation spray drift potential; capsule suspension; crop injury; emulsifiable concentrate; off-target movement; premix; tankmix.

Early-postemergence herbicide applications in the USA often include residual herbicides such as S-metolachlor to suppress late late-emerging Amaranthus spp. Although this practice benefits weed control, herbicide tankmixes can influence spray droplet size and drift potential during applications. The addition of S-metolachlor products to dicamba spray solutions generally decreases spray droplet size and increases spray drift potential. Advances in formulation technol. fostered the development of products with reduced spray drift potential, especially for herbicide premixes containing multiple active ingredients. The objective of this study was to compare the drift potential of a novel dicamba plus S-metolachlor premix formulation (capsule suspension) against a tankmix containing dicamba (soluble liquid) and S-metolachlor (emulsifiable concentrate) using different venturi nozzles. The MUG nozzle had greater DV0.5 (1128.6μm) compared to the ULDM (930.3μm), TDXL-D (872.9μm), and TTI nozzles (854.8μm). The premix formulation had greater DV0.5 (971.0μm) compared to the tankmix (922.3μm). Nozzle influenced spray drift deposition (P < 0.0001) and soybean biomass reduction (P = 0.0465). Herbicide formulation influenced spray drift deposition (P < 0.0001), and biomass reduction of soybean (P < 0.0001) and cotton (P = 0.0479). The novel capsule suspension formulation (premix) of dicamba plus S-metolachlor had reduced area under the drift curve (AUDC) (577.6) compared to the tankmix (913.7). Applications using the MUG nozzle reduced AUDC (459.9) compared to the other venturi nozzles (ranging from 677.4 to 1141.7). Study results evidence that advances in pesticide formulation can improve pesticide drift mitigation. Pest Management Science published new progress about Amaranthus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joehnck, Matthias; Kalveram, Stefan; Lehmacher, Stefan; Pompe, Guido; Rudolph, Stefan; Neyer, Andreas; Hofstraat, Johannes W. published the artcile< Characterization of passive polymer optical waveguides>, Product Details of C9H3F5O2, the main research area is polymer optical waveguide tetrachloroethylacrylate tetrachloroethylmethacrylate POPCORN technol; pentafluorophenylacrylatete pentafluorophenylmethacrylate polymer optical waveguide.

The characterization of monomode passive polymer optical devices fabricated according to the POPCORN technol. by methods originated from electron, ion and optical spectroscopy is summarized. Impacts of observed waveguide perturbations on the optical characteristics of the waveguide are evaluated. In the POPCORN approach optical components for telecommunication applications are fabricated by photo-curing of liquid halogenated (meth)acrylates which were applied on molded thermoplastic substrates. For tuning of waveguide material refractive indexes with respect to the substrate refractive index frequently comonomer mixtures are used. The polymerization characteristics, especially the polymerization kinetics of individual monomers, determine the formation of copolymers. Therefore the unsaturation as function of UV-illumination time in the formation of halogenated homo- and copolymers was examined From different suitable copolymer system, after characterization of their glass transition temperatures, their curing behavior and their refractive indexes as function of the monomer ratios, monomode waveguides applying PMMA substrates were fabricated. To examine the materials composition also in the 6 X 6 μm2 waveguides they were visualized by TEM. With this method, e.g., segregation phenomena could be observed in the waveguide cross section characterization as well. The optical losses in monomode waveguides caused by segregation and other materials induce defects like micro bubbles formed as a result of shrinkage were quantized by return loss measurements. Defects causing scattering could be observed by confocal laser scanning microscopy and by conventional light microscopy.

Proceedings of SPIE-The International Society for Optical Engineering published new progress about Optical waveguides. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Product Details of C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics