Month: October 2022

Yao, Xiaoliang; Yan, Dayun; Lin, Li; Sherman, Jonathan H.; Peters, Katherine B.; Keir, Stephen T.; Keidar, Michael published the artcile< Cold Plasma Discharge Tube Enhances Antitumoral Efficacy of Temozolomide>, Computed Properties of 112-63-0, the main research area is temozolomide plasma discharge tube antitumor glioblastoma drug sensitization; Temozolomide; antitumor; drug-sensitization; glioblastoma; plasma discharge tube.

Glioblastoma (GBM) is a fatal human brain tumor with a low survival rate. Temozolomide (TMZ) has been widely used in GBM therapy with noticeable side effects. Cold plasma is an ionized gas that is generated near room temperature Here, we demonstrated the enhancement therapeutic efficacy of TMZ via using a cold plasma source based on nonequilibrium plasma in a sealed glass tube, named a radial cold plasma discharge tube (PDT). The PDT affected glioblastoma cells’ function just by its electromagnetic (EM) emission rather than any chem. factors in the plasma. The PDT selectively increased the cytotoxicity of TMZ on two typical glioblastoma cell lines, U87MG and A172, compared with normal astrocyte cell line hTERT/E6/E7 to some extent. Furthermore, on the basis of a patient-derived xenograft model, our preliminary in vivo studies demonstrated the drastically improved mean survival days of the tumor-barrier mice by more than 100% compared to control. The PDT is not only independent of continuous helium supply but is also capable of resisting the interference of environmental changes. Thus, the PDT was a stable and low-cost cold atm. plasma source. In short, this study is the first to demonstrate the promising application of PDTs in GBM therapy as a noninvasive and portable modality.

ACS Applied Bio Materials published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weng, Wei-Zhao; Gao, Yin-He; Zhang, Xue; Liu, Yan-Hua; Shen, Ying-Jie; Zhu, Yan-Ping; Sun, Yuan-Yuan; Meng, Qing-Guo; Wu, An-Xin published the artcile< Oxidative C(sp3)-H functionalization of methyl-azaheteroarenes: a facile route to 1,2,4-triazolo[4,3-a]pyridines>, Electric Literature of 112-63-0, the main research area is triazolopyridine quinoline preparation; quinoline hydrazinyl pyridine oxidative cyclization.

An oxidative [4 + 1] annulation used to prepare 1,2,4-triazolo[4,3-a]pyridines e.g., I in the presence of I2-DMSO were described. This protocol enables synthesis of triazolo[4,3-a]pyridine-quinoline linked diheterocycles I via a direct oxidative functionalization of sp3 C-H bonds of 2-methyl-azaheteroarenes e.g., 2-methylquinoline. The reaction shows a wide substrate scope and good functional group tolerance.

Organic & Biomolecular Chemistry published new progress about C-H bond activation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joshi, Balawant S.; Viswanathan, Narayanan; Gawad, Dilip H.; Von Philipsborn, Wolfgang published the artcile< Carbon-13 NMR spectroscopy. 7. Piperaceae alkaloids. I. Structure of piperstachine. Carbon-13 and proton NMR studies>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Piper alkaloid piperstachine; NMR piperstachine; piperstachine structure; hexahydropiperstachine.

The structure of piperstachine (I), a new alkaloid from the stem of Piper trichostachyon C. DC, was determined based on its spectral data and the synthesis of hexahydropiperstachine (II).

Helvetica Chimica Acta published new progress about Alkaloids Role: PRP (Properties). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dutta, A. K.; Ryan, W.; Thomas, B. F.; Singer, M.; Compton, D. R.; Martin, B. R.; Razdan, R. K. published the artcile< Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs)>, COA of Formula: C19H34O2, the main research area is alkyloxy indole derivative preparation cannabimimetic structure.

Several novel 4-alkyloxy-aminoalkyl indole derivatives I (R = H, alkyl or alkylnaphthyl) were synthesized from 4-benzyloxyindole. Alkylation of 4-benzyloxyindole with 4-(2-chloroethyl)morpholine (NaH/HMPA) formed 4-benzyloxy-1-[2-(4-morpholinyl)ethyl]-1H-indole. Deprotection using palladium hydroxide on carbon/hydrogen followed by alkylation with the appropriate alkyl bromide gave the target compounds In the synthesis of two of the derivatives, the appropriate alkyl bromides were prepared from the com. available 1-naphthylethyl bromide using the chain lengthening sequences. In receptor binding assay and in vivo testing, the long chain alkoxy compounds (Ki = 127 nM) showed affinity for the CB1 receptor which was approx. 16-35-fold less than that of WIN 55,225. However, the pharmacol. profile of one of the derivatives mimics that of WIN 55,212. An examination of the SAR of these analogs shows that translocating the naphthyl group in AAIs from the C-3 position to C-4 via an oxygen (ether linkage) decreases activity which is in contrast to previous findings that a naphthylcarbonyl at C-4 retains activity. The present work points to the importance of the role of a keto group in the interaction with the receptor. Mol. modeling work suggests that, although reasonable superposition of key structural features between Δ9-THC and AAIs can be made, the overlay is not straightforward. The present study also illustrates the difficulty in accommodating AAIs into the cannabinoid pharmacophore and it seems likely that a unique pharmacophore will need to be developed. Only then will the similarities to and differences from the classical cannabinoid pharmacophore be clearly delineated.

Bioorganic & Medicinal Chemistry published new progress about Cannabinoid receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Miao; Luo, Zhao-Xiang; Li, Tian; Xiong, De-Cai; Ye, Xin-Shan published the artcile< Electrochemical Trifluoromethylation of Glycals>, Name: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is protective group fluoromethylation glycal catalyst electrochem redox.

Carbohydrates play essential roles in various physiol. and pathol. processes. Trifluoromethylated compounds have wide applications in the field of medicinal chem. Herein, we report a practical and efficient trifluoromethylation of glycals by an electrochem. approach using CF3SO2Na as the trifluoromethyl source and MnBr2 as the redox mediator. A variety of trifluoromethylated glycals bearing different protective groups are obtained in 60-90% yields with high regioselectivity. The successful capture of a CF3 radical indicates that a radical mechanism is involved in this reaction.

Journal of Organic Chemistry published new progress about Glycals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Name: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crosby, John; Moilliet, Jock; Parratt, Julian S.; Turner, Nicholas J. published the artcile< Regioselective hydrolysis of aromatic dinitriles using a whole cell catalyst>, HPLC of Formula: 112-63-0, the main research area is regioselective hydrolysis aromatic dinitrile biochem catalyst; whole cell catalyst hydrolysis aromatic dinitrile.

A series of aromatic dinitriles have been examined as substrates for an immobilized whole cell Rhodococcus sp. that catalyzes the hydrolysis of nitriles to amides and/or carboxylic acids. The fluorinated aromatic dinitriles were regioselectivity hydrolyzed to the corresponding cyano amides whereas the non-fluorinated analogs were converted to cyano acids but with poorer regioselectivity.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Brevibacterium Role: CAT (Catalyst Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khan, Ali; Pervaiz, Aini; Ansari, Bushra; Ullah, Riaz; Shah, Syed Muhammad Mukarram; Khan, Haroon; Saeed Jan, Muhammad; Hussain, Fida; Ijaz Khan, Mohammad; Albadrani, Ghadeer M.; Altyar, Ahmed E.; Abdel-Daim, Mohamed M. published the artcile< Phytochemical Profiling, Anti-Inflammatory, Anti-Oxidant and In-Silico Approach of Cornus macrophylla Bioss (Bark)>, Quality Control of 112-63-0, the main research area is Cornus macrophylla antiinflammatory antioxidant phytochem profiling; Cornus macrophylla; GC-MS; anti-inflammatory; antioxidant.

The objective of the current study was to evaluate the phytochem. and pharmacol. potential of the Cornus macrophylla. C. macrophylla belongs to the family Cornaceae. It is locally known as khadang and is used for the treatment of different diseases such as analgesic, tonic, diuretic, malaria, inflammation, allergy, infections, cancer, diabetes, and lipid peroxidative. The crude extract and different fractions of C. macrophyll were evaluated by gas chromatog. and mass spectroscopy (GC-MS), which identified the most potent bioactive phytochems. The antioxidant ability of C. macrophylla was studied by 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) and 1,1 diphenyl-2-picryl-hydrazyl (DPPH) methods. The crude and subsequent fractions of the C. macrophylla were also tested against anti-inflammatory enzymes using COX-2 (Cyclooxygenase-2) and 5-LOX (5-lipoxygenase) assays. The mol. docking was carried out using mol. operating environment (MOE) software. The GC-MS study of C. macrophylla confirmed forty-eight compounds in Et acetate (Et.AC) fraction and revealed that the Et.AC fraction was the most active fraction. The antioxidant ability of the Et.AC fraction showed an IC50 values of 09.54μg/mL and 7.8μg/mL against ABTS and DPPH assay resp. Among all the fractions of C. macrophylla, Et.AC showed excellent activity against COX-2 and 5-LOX enzyme. The observed IC50 values were 93.35μg/mL against COX-2 and 75.64μg/mL for 5-LOX resp. Mol. docking studies supported these in vitro results and confirmed the anti-inflammatory potential of C. macrophylla. C. macrophylla has promising potential as a source for the development of new drugs against inflammation in the future.

Molecules published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rohrbacher, Florian; Zwicky, Andre; Bode, Jeffrey W. published the artcile< Chemical synthesis of a homoserine-mutant of the antibacterial, head-to-tail cyclized protein AS-48 by α-ketoacid-hydroxylamine (KAHA) ligation>, COA of Formula: C9H9NO4, the main research area is alphaketoacid hydroxylamine ligation antibacterial protein homoserine mutant.

An antibacterial cyclic AS-48 protein was chem. synthesized by α-ketoacid-hydroxylamine (KAHA) ligation. Initial challenges associated with the exceptionally hydrophobic segments arising from the amphiphilic nature of the protein were resolved by the development of bespoke reaction conditions for hydrophobic segments, using hexafluoroisopropanol (HFIP) as a co-solvent. The synthetic protein displays similar biol. activity and properties to those of the native protein. To support the current understanding of its antibacterial mode of action, we demonstrate the ability of AS-48 to be incorporated into synthetic multilamellar vesicles (MLVs).

Chemical Science published new progress about Antibacterial agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, COA of Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Biao; Chen, Wenjun; Zhao, Qiongli; Yu, Wenquan; Chang, Junbiao published the artcile< Synthesis of Functionalized Imidazolium Salts via Iodine-Mediated Annulations of Enamines>, SDS of cas: 94-02-0, the main research area is imidazolium salt preparation; enamine preparation annulation iodine.

A novel annulation reaction of two enamine mols. with iodine under basic conditions to form 4-functionalized imidazolium salts has been established. In this reaction, iodine acts as both an iodinating reagent and a Lewis acid catalyst. Features of this synthetic method include facilitative preparation of substrates, no use of transition metals, mild reaction conditions, simplicity of operation, and gram scale synthesis.

Organic Letters published new progress about Cyclization. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, SDS of cas: 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Ning; Nagai, Atsushi; Jiang, Donglin published the artcile< Anthracene-based covalent organic frameworks and layer locking-and-unlocking driven by external stimuli>, Computed Properties of 112-63-0, the main research area is anthracene covalent organic framework locking driven stimuli.

Covalent organic frameworks (COFs) are an intriguing class of crystalline porous polymers, which allow the covalent integration of organic units into periodicity. Because of their high surface area, excellent thermal stability, and low densities, COFs have emerged as a new media for gas adsorption. We have synthesized various COFs with π electronic building blocks and developed light-emitting, semiconducting, photoconducting, and charge separating properties.

PMSE Preprints published new progress about Absorption spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics