Month: October 2022

Yuan, Tengteng; Lv, Shujie; Zhang, Wei; Tang, Yanan; Chang, Hong; Hu, Zihan; Fang, Liang; Du, Jiaojiao; Wu, Sifan; Yang, Xinli; Guo, Yangfu; Guo, Ruihan; Ge, Zongrui; Wang, Lei; Zhang, Caiyun; Wang, Rulin; Chen, Weidong published the artcile< PF-PLC micelles ameliorate cholestatic liver injury via regulating TLR4/MyD88/NF-κB and PXR/CAR/UGT1A1 signaling pathways in EE-induced rats>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is 17α-ethynylestradiol; CAR; Cholestasis liver injury; MyD88; NF-κB pathway; PF-PLC micelles; PXR; TLR4; UGT1A1.

Paeoniflorin (PF) has a certain therapeutic effect on cholestasis liver injury. To further improve the bioavailability of PF and play its pharmacol. role in liver protection, PF-phospholipid complex micelles (PF-PLC micelles) were prepared based on our previous research on PF-PLC. The protective effects of PF and PF-PLC micelles on cholestasis liver injury induced by 17α-ethynylestradiol (EE) were compared, and the possible mechanisms were further explored. Herein, we showed that PF-PLC micelles effectively improved liver function, alleviated liver pathol. damage, and localized infiltration of inflammatory cells. Mechanism studies indicated that PF-PLC micelles treatment could suppress the TLR4/MyD88/NF-κB pathway, and further reduce the levels of pro-inflammatory factors. Meanwhile, our exptl. results demonstrated that the beneficial effect of PF-PLC micelles on EE-induced cholestasis may be achieved by the upregulation of nuclear receptors and metabolic enzymes (PXR/CAR/UGT1A1). All these results indicate that PF-PLC micelles have great potential in the treatment of cholestatic liver disease.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kubisch, Christin; Ochsenreither, Katrin published the artcile< Valorization of a Pyrolytic Aqueous Condensate and Its Main Components for L-Malic Acid Production with Aspergillus oryzae DSM 1863>, Application In Synthesis of 112-63-0, the main research area is Aspergillus malic acid valorization pyrolytic aqueous condensate.

Pyrolytic aqueous condensate (PAC) might serve as a cost-effective substrate for microbial malic acid production, as it is an unused side stream of the fast pyrolysis of lignocellulosic biomass that contains acetol and acetate as potential carbon sources. In the present study, shake flask cultures were performed to evaluate the suitability of acetol and its combination with acetate as substrates for growth and L-malate production with the filamentous fungus Aspergillus oryzae. Acetol concentrations of up to 40 g/L were shown to be utilized for fungal growth. In combination with acetate, co-metabolization of both substrates for biomass and malate formation was observed, although the maximum tolerated acetol concentration decreased to 20 g/L. Furthermore, malate production on PAC detoxified by a combination of rotary evaporation, overliming and activated carbon treatment was studied. In shake flasks, cultivation using 100% PAC resulted in the production of 3.37 ± 0.61 g/L malate, which was considerably improved by pH adjustment up to 9.77 ± 0.55 g/L. A successful scale-up to 0.5-L bioreactors was conducted, achieving comparable yields and productivities to the shake flask cultures. Accordingly, fungal malate production using PAC was successfully demonstrated, paving the way for a bio-based production of the acid.

Fermentation published new progress about Aspergillus oryzae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Ning; Ding, Xuesong; Kim, Jangbae; Ihee, Hyotcherl; Jiang, Donglin published the artcile< A Photoresponsive Smart Covalent Organic Framework>, Related Products of 112-63-0, the main research area is anthracene covalent organic framework photoinduced cycloaddition reaction; anthracene; covalent organic frameworks; photoresponsive materials; porous polymer; smart materials.

Ordered π-columnar structures found in covalent organic frameworks (COFs) render them attractive as smart materials. However, external-stimuli-responsive COFs have not been explored. Here we report the design and synthesis of a photoresponsive COF with anthracene units as the photoresponsive π-building blocks. The COF is switchable upon photoirradiation to yield a concavo-convex polygon skeleton through the interlayer [4π+4π] cycloaddition of anthracene units stacked in the π-columns. This cycloaddition reaction is thermally reversible; heating resets the anthracene layers and regenerates the COF. These external-stimuli-induced structural transformations are accompanied by profound changes in properties, including gas adsorption, π-electronic function, and luminescence. The results suggest that COFs are useful for designing smart porous materials with properties that are controllable by external stimuli.

Angewandte Chemie, International Edition published new progress about Covalent organic frameworks. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Kenji; Takaishi, Hideo published the artcile< Synthetic microbial chemistry. XXII. Synthesis of monocerin, an antifungal, insecticidal and phytotoxic heptaketide metabolite of Exserohilum monoceras>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is monocerin total synthesis.

Both the naturally occurring enantiomer I and the racemate of monocerin were synthesized for the first time.

Tetrahedron published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Le Marechal, Jean-Francois published the artcile< Bromination of alkenes: between chemical and pedagogical improvements>, Electric Literature of 112-63-0, the main research area is bromination alkene pedagogical.

The bromination of stilbene is used to illustrate some chem. concepts that are difficult for student comprehension. The mechanism of trans-stilbene bromination by pyridinium tribromide is compared to that by bromine. The solvent effect on the reaction stereochem. is also discussed. The use of binary phase diagrams is used to discuss the racemate of the reaction products.

BUP published new progress about Alkenes Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Minghe; Li, Lin; Huang, Ming; Tan, Yao; Shang, Ye; Meng, Xianghui; Pang, Yafen; Xu, Hong; Zhao, Xin; Lei, Wei; Chang, Yanxu; Wang, Yi; Zhang, Deqin; Zhang, Boli; Li, Yuhong published the artcile< Sanye tablet ameliorates insulin resistance and dysregulated lipid metabolism in high-fat diet-induced obese mice>, Application In Synthesis of 112-63-0, the main research area is Sanye tablet insulin lipid metabolism lipidomics proteomics; HFD; SYT; insulin resistance; lipidomics; proteomics.

Sanye Tablet (SYT) is a patent prescription widely used in treating T2D and pre-diabetes, especially T2D comorbid with hypertriglyceridemia, for many years in China. However, the underlying mechanism that accounts for the anti-diabetic potential of SYT by regulating lipid-related intermediates remains to be elucidated. This study aimed to investigate the mechanism of SYT on lipid metabolism and insulin sensitivity in high-fat diet (HFD)-induced obese mice by means of combining lipidomics and proteomics. The obese mice models were developed via HFD feeding for 20 consecutive weeks. Mice in the treatment group were given metformin and SYT resp., and the effects of SYT on body weight, blood glucose, insulin sensitivity, fat accumulation in the organs, and pathol. changes in the liver were monitored. Lipid metabolism was examined by lipidomics. Further determination of signaling pathways was detected by proteomics. The biol. contributions of the compounds detected in SYT′s chem. fingerprint were predicted by network pharmacol. SYT treatment reduced body weight, inhibited viscera and hepatic steatosis lipid accumulation, and prevented insulin resistance. Furthermore, it was found that circulatory inflammatory cytokines were reduced by SYT treatment. In addition, lipidomics anal. indicated that SYT targets lipid intermediates, including diacylglycerol (DAG) and Ceramide (Cer). Mechanistically, SYT pos. affected these lipid intermediates by suppressing liver lipogenesis via downregulation of SREBP1/ACC and the JAK/STAT signaling pathway. Our results predicted that astragalin and rosmarinic acid might regulate the JAK-STAT pathway by targeting PIM2 and STAT1, resp., while paeoniflorin and rosmarinic acid were likely to regulate inflammatory responses by targeting TNFα, IL-6, and IL-4 during T2D. Overall, our study provides supportive evidence for the mechanism of SYT′s therapeutic effect on dysregulated lipid metabolism in diabesity.

Frontiers in Pharmacology published new progress about Antiinflammatory cytokines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sharif, Mariam; Anjum, Irfan; Shabbir, Arham; Mushtaq, Muhammad Naveed published the artcile< Anti-asthmatic effect of Juglans regia Linn. in mice>, Application of C19H34O2, the main research area is Juglans allergic asthma antiasthmatic phytochems.

Plants are considered as an essential source to treat different diseases. In traditional system of medicine, Juglans regia (J. regia) has been used in curing sinusitis and cough. The aim of the present study was to evaluate the anti-asthmatic activity of J. regia in ovalbumin-induced allergic asthmatic BALB/c mice. The mice were sensitized i.p. and subsequently challenged with ovalbumin (intranasal) to induce allergic asthma. Mice were treated with methanolic, n-hexane and Et acetate extracts of J. regia and methylprednisolone for 7 consecutive days, along with intranasal challenge. The total and differential leukocyte counts in blood, bronchoalveolar lavage fluid (balf) and lung wet/dry ratio were determined GC-MS anal. was also performed. The results showed that Et acetate extract of J. regia significantly reduced inflammatory cells count in both blood and balf more significantly. Lung wet/dry weight ratio was reduced in asthmatic mice treated with the different extracts of J. regia. Serum IgE antibodies level was also significantly decreased in extracts treated groups. GC-MS anal. of all three extracts of J. regia showed the presence of various phytochems. responsible for its anti-inflammatory and anti-asthmatic activity. The results of the present study validated the traditional use of J. regia in respiratory disorders like asthma and sinusitis.

Pakistan Journal of Pharmaceutical Sciences published new progress about Allergic asthma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diaz-Sanchez, Blanca R.; Iglesias-Arteaga, Martin A.; Melgar-Fernandez, Roberto; Juaristi, Eusebio published the artcile< Synthesis of 2-Substituted-5-halo-2,3-dihydro-4(H)-pyrimidin-4-ones and Their Derivatization Utilizing the Sonogashira Coupling Reaction in the Enantioselective Synthesis of α-Substituted β-Amino Acids>, Formula: C19H34O2, the main research area is pyrimidinone dihydro derivative preparation enantioselective conversion beta amino acid; crystal structure dihydropyrimidinone; mol structure dihydropyrimidinone.

A convenient, one-pot procedure for the synthesis of 1-benzoyl-2(S)-substituted-5-iodo-2,3-dihydropyrimidin-4(1H)-ones by tandem decarboxylation/β-iodination of the corresponding 6-carboxy-perhydropyrimidin-4-ones was developed. Several 1-benzoyl-2(S)-substituted-5-bromo-2,3-dihydropyrimidin-4(1H)-ones were readily prepared by bromination of 1-benzoyl-2(S)-substituted-2,3-dihydropyrimidin-4(1H)-ones. Subsequently, Sonogashira coupling of the halogenated heterocyclic enones with various terminal alkynes produced 1-benzoyl-2(S)-isopropyl-5-alkynyl-2,3-dihydropyrimidin-4(1H)-ones in good yields. Hydrogenation of the unsaturated C-C moieties in a Sonogashira product followed by acid hydrolysis afforded a highly enantioenriched α-substituted β-amino acid (S)-2-(aminomethyl)-4-phenylbutanoic acid. The crystal and mol. structures of 1-benzoyl-2(S)-phenyl-2,3-dihydropyrimidin-4(1H)-one, 1-benzoyl-2(S)-isopropyl-5-bromo-2,3-dihydropyrimidin-4(1H)-one, 1-benzoyl-2(S)-isopropyl-5-phenylethynyl-2,3-dihydropyrimidin-4(1H)-one were determined by x-ray crystallog.

Journal of Organic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zou, Ying; Fahmi, Nour Eddine; Vialas, Corine; Miller, Guy M.; Hecht, Sidney M. published the artcile< Total Synthesis of Deamido Bleomycin A2, the Major Catabolite of the Antitumor Agent Bleomycin>, Formula: C12H24N2O4, the main research area is deamido bleomycin A2 total synthesis; demethyl deamido bleomycin A2 total synthesis; aglycon deamido bleomycin A2 total synthesis; DNA relaxation cleavage deamido bleomycin A2.

This work describes the synthesis of deamido-demethyl-bleomycin A2, I (R = SMe) and deamido-bleomycin A2, I (R = SMe2), as well as their resp. aglycons. Amino ester II was the key intermediate for I. Synthetic deamido-bleomycin A2 was shown to be identical to the product formed by treatment of bleomycin A2 (BLM-A2) with bleomycin hydrolase, as judged by reversed-phase HPLC anal. and 1H NMR spectroscopy. Deamido-bleomycin A2 was found to retain significant DNA cleavage activity in DNA plasmid relaxation assays and had the same sequence selectivity of DNA cleavage as bleomycin A2. The most significant alteration of function noted in this study was a reduction in the ability of deamido-bleomycin A2 to mediate double-strand DNA cleavage, relative to that produced by BLM-A2.

Journal of the American Chemical Society published new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Formula: C12H24N2O4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Jianqiang; Gu, Wenjing; Ma, Ning; Fan, Xiaoye; Ci, Xinxin published the artcile< Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway>, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is leonurine cisplatin ferroptosis acute kidney injury Nrf signalling pathway; Nrf2; cisplatin-induced acute kidney injury; ferroptosis; leonurine.

Evidence indicates that ferroptosis plays a key role in acute kidney injury induced by cisplatin. The Nrf2/NRF2 pathway regulates oxidative stress, lipid peroxidation and pos. regulates cisplatin-induced acute kidney injury, but its effect along with the alkaloid leonurine, found in motherwort, on ferroptosis after such acute kidney injury remains unclear. The anti-ferroptotic effects of Nrf2 and leonurine were assessed in a mouse model of cisplatin-induced acute kidney injury. In vitro, the effects of leonurine on erastin- and RSL3-induced HK-2 human PTEC ferroptosis were examined Nrf2 deletion induced ferroptosis-related protein expression and iron accumulation in vivo, aggravating cisplatin-induced acute kidney injury. Leonurine activated Nrf2 and prevented iron accumulation, lipid peroxidation and ferroptosis in vitro, being abolished in siNrf2-treated cells. Moreover, leonurine potently inhibited cisplatin-induced renal damage, as assessed by of serum creatinine, blood urea nitrogen, kidney injury mol.-1 and NGAL. Importantly, leonurine activated the Nrf2 antioxidative pathway and preventing changes in ferroptosis-related morphol. and biochem. indicators, malondialdehyde level, SOD and GSH depletion, and GPX4 and xCT down-regulation, in cisplatin-induced acute kidney injury. Nrf2 KO mice were more susceptible to ferroptosis after cisplatin-induced acute kidney injury than control mice. The protective effects of leonurine on acute kidney injury and ferroptosis were largely abolished in Nrf2 KO mice. These data suggest that renal protective effects of Nrf2 activation on cisplatin-induced acute kidney injury are achieved, at least partially, by inhibiting lipid peroxide-mediated ferroptosis, highlighting the potential of leonurine in acute kidney injury treatment.

British Journal of Pharmacology published new progress about Acute kidney injury. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics