Month: October 2022

Du, Xiaohui; Kim, Yong-Jae; Lai, SuJen; Chen, Xi; Lizarzaburu, Mike; Turcotte, Simon; Fu, Zice; Liu, Qingxiang; Zhang, Ying; Motani, Alykhan; Oda, Kozo; Okuyama, Ryo; Nara, Futoshi; Murakoshi, Michiko; Fu, Angela; Reagan, Jeff D.; Fan, Peter; Xiong, Yumei; Shen, Wang; Li, Leping; Houze, Jonathan; Medina, Julio C. published the artcile< Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phenylalanine derivative preparation GPR142 agonists NIDDM diabetes.

GPR142 is a novel GPCR that is predominantly expressed in pancreatic β-cells. GPR142 agonists potentiate glucose-dependent insulin secretion, and therefore can reduce the risk of hypoglycemia. Optimization of our lead pyridinone-phenylalanine series led to a proof-of-concept compound 22, which showed in vivo efficacy in mice with dose-dependent increase in insulin secretion and a decrease in glucose levels.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

zur Borg, Lisa; Schuell, Christoph; Frey, Holger; Zentel, Rudolf published the artcile< Directing the Self-Assembly of Semiconducting Copolymers: The Consequences of Grafting Linear or Hyperbranched Polyether Side Chains>, HPLC of Formula: 71195-85-2, the main research area is self assembly semiconducting copolymer grafting linear hyperbranched polyether chain; Block copolymers; hyperbranched polyglycerols; micelles; poly(para-phenylene vinylene); semiconducting materials.

The synthesis and self-assembly of novel semiconducting rod-coil type graft block copolymers based on poly(para-phenylene vinylene) (PPV) copolymers is presented, focusing on the ordering effect of linear vs. hyperbranched side chains. Using an addnl. reactive ester block, highly polar, linear poly(ethylene glycol), and hyperbranched polyglycerol side chains are attached in a grafting-to approach. Remarkably, the resulting novel semiconducting graft copolymers with polyether side chains show different solubility and side-chain directed self-assembly behavior in various solvents, e.g., cylindrical or spherical superstructures in the size range of 10 to 120 nm, as shown by TEM. By adjusting the mol. weight and the topol. of the polyether segments, self-assembly into defined superstructures can be achieved, which is important for the efficient charge transport in potential electronic applications.

Macromolecular Rapid Communications published new progress about Branched polymers, hyperbranched dendritic polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (polyether-polyphenylenevinylenes, diblock, graft). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Potikha, L. M.; Kovtunenko, V. O. published the artcile< Rearrangement of benzyl derivatives of condensed 3-aminoisoquinolinones>, Application of C19H34O2, the main research area is benzophenathridine preparation; isoquinoIinenone isoquinazolinone phenylacetonitrile rearrangement.

A new method for contructing the benzo[b]phenathridine system is proposed. Melting of benzimidazo[1,2-b]isoquinoline-11(5H)-one or 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one with [2-(bromomethyl)phenyl]acetonitrile leads to the formation of C-benzylation products, which is accompanied by intramol. acylation over the β-Carbon of the enamine fragment of the mols. Heating the fusion product in the presence of an acid provokes splitting of the isoquinoline ring and rearrangement to the 12,12a-dihydrobenzo[b]phenanthridine-5(6H)-one derivatives The features of the spatial structure of reaction products and their chem. behavior are considered.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about Phenanthridines Role: SPN (Synthetic Preparation), PREP (Preparation) (benzo). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ayoola, A. A.; Alagbe, E. E.; Agboola, O.; Ayeni, O. A.; Adeyemi, G. A.; Nnabuko, D.; Niakinwa, T. A. published the artcile< A simplified design for biodiesel production>, Product Details of C19H34O2, the main research area is biodiesel design esterification production.

In this research work, a simple design for the production of 1kg biodiesel involving two stage esterification-transesterification process, with the use of waste soybean oil (WSO) and NaOH catalyst was considered. CHEMCAD 7.1.2 software was used for the design operation which revealed that four (4) pumps, four (4) heaters, two (2) mixers, one (1) drying equipment and two (2) reactors were involved. Also, the production process design revealed that 0.05 13kg/h of methanol and 0.1 800kg/h of 0.1M H2SO4 were required during the esterification process. While 0.6921kg/h of methanol, 0.9870kg/h of WSO as well as 0.1934kg/h of NaOH catalyst were needed for the transesterification process. The simplicity of the design and high purity level of the biodiesel produced adjudged the design operation good.

IOP Conference Series: Materials Science and Engineering published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Dezhong; Li, Zhi; Li, Xiang; Chen, Xin; Li, Zhen; Yuan, Lixia; Huang, Yunhui published the artcile< Stable Room-Temperature Sodium-Sulfur Batteries in Ether-Based Electrolytes Enabled by the Fluoroethylene Carbonate Additive>, Synthetic Route of 112-63-0, the main research area is stable room temperature sodium sulfur battery ether electrolytes enabled; cathode−electrolyte interphase; electrolyte additive; room-temperature sodium−sulfur batteries; sulfurized polyacrylonitrile cathode; “solid−solid” conversion.

Because of its high energy d. and low cost, the room-temperature sodium-sulfur (RT Na-S) battery is a promising candidate to power the next-generation large-scale energy storage system. However, its practical utilization is hampered by the short life span owing to the severe shuttle effect, which originates from the “”solid-liquid-solid”” reaction mechanism of the sulfur cathode. In this work, fluoroethylene carbonate is proposed as an additive, and tetraethylene glycol di-Me ether is used as the base solvent. For the sulfurized polyacrylonitrile cathode, a robust F-containing cathode-electrolyte interphase (CEI) forms on the cathode surface during the initial discharging. The CEI prohibits the dissolution and diffusion of the soluble intermediate products, realizing a “”solid-solid”” reaction process. The RT Na-S cell exhibits a stable cycling performance: a capacity of 587 mA h g-1 is retained after 200 cycles at 0.2 A g-1 with nearly 100% Coulombic efficiency.

ACS Applied Materials & Interfaces published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Buchi, J.; Enezian, O.; Eichenberger, H.; Lieberherr, R. published the artcile< Synthesis and pharmacological action of some dialkylmalonic acid derivatives. Dialkylaminoethyl amides and esters of dialkylaminoethanols>, Quality Control of 112-63-0, the main research area is .

Heating 1 mol RR’C(CO2Et)2 in 150 mL. EtOH with 70 g. KOH in 150 mL. EtOH 2 h., evaporating the EtOH, ice-cooling, extracting with ether, HCl addition, and distillation give EtOCOCRR’CO2H (I) [R,R’, b.p., and yields (%)]: Me, Me, b0.5 93-5°, 87.5%; Et, Et, b0.4 92°, 50; Et, Pr, b0.15 118°, 72; Et, Bu, b2 133°, 96; and Pr, iso-Pr, b0.45 107°, 42.I and SOCl2 give EtOCOCRR’COCl(II): Me, Me, b1666°, 96; Et, Et, b20 93-5°, 96; Et, Pr, b15 107°, 93; Et, Bu, b20 123°, 86; and Pr, iso-Pr, b16 112°, 70. II (1 mol) in C6H6, 0.5 mol Na2CO3, and 1 mol R”R”’NCH2CH2NH2 give after heating and filtering RR’C(CO2Et)CONH(CH2)2 NR”R”’-(R, R’, R”, R”’, b.p., yield (%), and m.p. of HCl salt): Et, Et, Me, Me, b0.3 102-3°, 40, 105.5°; Me, Me, Et, Et, b0.35 108°, 80, 76-7°; Et, Et, Et, Et, b0.5 119°, 80, 104-5°; Et, Pr, Et, Et, b0.6 124°, 94, 39°; Et, Bu, Et, Et, b0.6 130°, 70; -; iso-Pr, Pr, Et, Et, b0.5 134°, 77, -. R”R”’NCH2CH2OH and II give RR’C(CO2Et)CO2(CH2)2NR”R”’: Et, Et, Me, Me, b0.2 112-14°, 49, 90.5°, Et, Et, Et, Et, b0.7 113.5°, 78-80, 105°; Et, Bu, Et, Et, b0.45 120°, 80, 93°; Et, Et, Bu, Bu, b0.4 130°, 83, -. The following Et2C(COR)2 derivatives are given (R, b.p., m.p., yield (%), and m.p. of di-HCl salt); NH(CH2)2NMe2, b0.2 159°, 32°, 48, 154°; NH(CH2)2NEt2, b0.7 174°, 47°, 88, 155°; O(CH2)2NEt2, b0.3 142°, -, 55, 162°. Pharmacol. data of these compounds are presented.

Helvetica Chimica Acta published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lesley, Scott A.; Patten, Phillip A.; Schultz, Peter G. published the artcile< A genetic approach to the generation of antibodies with enhanced catalytic activities>, COA of Formula: C19H34O2, the main research area is catalytic antibody recombinant hydrolase activity; mol cloning gene hydrolytic catalytic antibody; Escherichia hydrolytic catalytic antibody expression selection; genetic selection hydrolytic catalytic antibody.

A hydrolytic catalytic antibody, generated against a nitrophenyl phosphonate transition state analog, has been cloned and expressed in Escherichia coli for use as a model system to demonstrate the feasibility of using genetic selections to enhance catalytic activity. Conditions were found that permit the secretion of active recombinant antibody into the periplasm of a strain of E. coli deficient in the biotin biosynthetic genes (Δbio-gal). A number of substrates were synthesized that, upon hydrolysis by the antibody, yield free biotin, which is required for cell growth. The substrates and selections can be used to identify mutants of the antibody with altered activities. This approach should be generalizable to a wide number of hydrolytic reactions including the selective cleavage of peptide, polysaccharide, phosphodiester, and ester bonds.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Animal gene Role: PRP (Properties). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Laha, Joydev K.; Bhimpuria, Rohan A.; Mule, Gajanan B. published the artcile< Site-Selective Oxidative C4 Alkenylation of (NH)-Pyrroles Bearing an Electron-Withdrawing C2 Group>, Formula: C8H9NO3, the main research area is pyrrole oxidative alkenylation.

A regioselective method for the oxidative C-H alkenylation of free (NH)-pyrroles with various activated and unactivated alkenes to afford 4-alkenylated (NH)-pyrroles in good to excellent yields was explored. The key features that distinguish this method from those reported in the current literature include: 1) the first report of the oxidative C4 alkenylation of (NH)-pyrroles, 2) utilization of neutral conditions, 3) C2-substituent-controlled oxidative C4 alkenylation irresp. of the nature of the free (NH)-pyrroles or N-protected pyrroles used, 4) scope of using both electron-deficient mono- and disubstituted alkenes and styrenes, and 5) synthesis of novel, enantiomerically pure 4-alkenyl-α-methyl-N-benzylpyrroles bearing a stereocenter. An important application of this process to the synthesis of indoles through tandem C4/C5 double alkenylation followed by electrothermal cyclization was also examined

ChemCatChem published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Formula: C8H9NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Song, Zhen; Zhou, Teng; Qi, Zhiwen; Sundmacher, Kai published the artcile< Computer-aided screening of deep eutectic solvent systems for the associative extraction of α-tocopherol from deodorizer distillate>, Application In Synthesis of 112-63-0, the main research area is tocopherol deodorizer distillate eutectic solvent system extraction.

This work presents a computer-aided framework for the screening of deep eutectic solvent (DES) systems by using the α-tocopherol extraction from methylated oil deodorizer distillates (MODD) as an example of practical relevance. Taking advantage of the differences in the hydrogen bond donating abilities of α-tocopherol and methyllinoleate (model compounds in MODD), the DES screening task is to select suitable components that can achieve the associative extraction of α-tocopherol by in situ DES formation at high selectivity against methyllinoleate. The COSMO-RS model is employed in the DES screening for two purposes: (1) The solid-liquid equilibrium between α-tocopherol and each candidate component are calculated to check the potential for DES formation and identify the existence of a proper liquid window. (2) The infinite dilution capacity and selectivity of different components for the α-tocopherol/methyllinoleate extraction are predicted to estimate their potential for the separation task. The components preselected by COSMO-RS evaluation are further examined regarding other phys. as well as environmental, health, and safety (EHS) properties.

Computer-Aided Chemical Engineering published new progress about Deep eutectic solvents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiao, Jun-An; Li, Yu-Chun; Luo, Zhi-Jin; Cheng, Xiu-Liang; Deng, Zhi-Xiong; Chen, Wen-Qiang; Su, Wei; Yang, Hua published the artcile< Construction of Bispirooxindole Heterocycles via Palladium-Catalyzed Ring-Opening Formal [3 + 2]-Cycloaddition of Spirovinylcyclopropyl Oxindole and 3-Oxindole Derivatives>, Electric Literature of 30095-98-8, the main research area is palladium catalyst ring opening formal cycloaddition spirovinylcyclopropyl oxindole isatin; bispirooxindole heterocycle stereoselective preparation.

A palladium-catalyzed ring-opening oxo-formal [3 + 2]-cycloaddition reaction of novel donor-acceptor spirovinylcyclopropyl oxindole with 3-oxindole is described. The developed protocol provides facile access to oxo-bispirooxindole derivatives in good yields (up to 82% yield) with excellent diastereoselectivities (up to 20:1 dr).

Journal of Organic Chemistry published new progress about [3+2] Cycloaddition reaction, stereoselective (formal). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics