Month: October 2022

Rawal, Viresh H.; Cava, Michael P. published the artcile< Photocyclization of pyrrole analogs of stilbene: an expedient approach to antitumor agent CC-1065>, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is oxidation photochem cyclization pyrrolylethene; pyrroloindole; thienoindole; furoindole; benzindole.

Heterocycles were converted into pyrrole analogs of stilbene and subsequently cyclized to give the tricyclic ring structure necessary for CC-1065 and its analogs. Thus, Wittig reaction of the phosphonium salt I (R = Me) with the aldehydes II (X = NMe, S, O, R1 = H) and 4-MeOC6H4CHO gave 84-90% Wittig olefination products, which underwent oxidative photocyclization to give 38-80% tricyclic product III (X = NMe, S, O, R = Me, R1 = H) and IV. Analogously, Wittig reaction of I (R = CH2Ph) with II (X = NCH2Ph, R1 = CO2Et) gave, after oxidative cyclization, 78% III (X = NCH2Ph, R = CH2Ph, R1 = CO2Et), which on selective reduction of the more electron rich side gave the corresponding tricyclic phosphodiesterase type unit.

Journal of the Chemical Society, Chemical Communications published new progress about Oxidative cyclization. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Wenjuan; Yu, Huizhu; Zhu, Xiaoquan; Li, Haoran published the artcile< A luminescence europium Metal-organic coordination polymer for Room-Temperature X-ray detection>, Quality Control of 112-63-0, the main research area is preparation europium pyrenetetrasulfonate coordination polymer xray detection luminescence scintillator.

A novel Eu ions-based metal-organic coordination polymer (MOCP) named Eu(1,3,6,8-PTS)(H2O)7·4H2OHbipy (1) (PTS = pyrenetetrasulfonic acid) was prepared, and its structure, stability, photoluminescence and scintillation properties were systematically investigated. Compound 1 gives a peculiar snake-shaped chain structure with the aid of π-π stacking effect of 4,4′-bipyridine auxiliary template. An efficient and stable light emission was detected under x-ray irradiation, which presents an excellent linear response to X-ray dose. Also, this compound demonstrates high radiation stability, illustrating its potential as a scintillator for x-ray detection. This work not only provides guidance for the design and fabrication of sulfonic ligand derived MOCPs with Eu (III) ions coordination, but also demonstrates the potential of MOCPs scintillators for x-ray detection technol.

Inorganic Chemistry Communications published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kierys, Agnieszka; Zaleski, Radoslaw; Grochowicz, Marta; Gorgol, Marek; Sienkiewicz, Andrzej published the artcile< Polymer-mesoporous silica composites for drug release systems>, Application In Synthesis of 3290-92-4, the main research area is polymer mesoporous silica composite drug.

The research describes systematic approach to the novel synthesis and formation of a potential organic-inorganic drug carriers. The poly(trimethylolpropane trimethacrylate) and polymer-silica composites based on SBA-3 or SBA-15 mesoporous silica were fabricated by the suspension-emulsion polymerization method in the form of small micrometric porous beads (sp. surface area approx. 500 m2/g). The type of organic templates filling silica pores has proved to be crucial in the synthesis of the composites. The introduction of diclofenac sodium via solvent diffusion method into the polymer and composites resulted in the solid drug dispersions. The composites have greater effectiveness in the drug desorption (90% of the release) in comparison with the pure polymer (20% of the release after 7 h). Both, however, suffer from the burst effect. This downside can be overcome by functionalization of the solid drug dispersions with (3-aminopropyl)triethoxysilane. The functionalized solid drug dispersions do not desorb the diclofenac sodium in an acidic medium (the desorption rate is less than 6% during 2 h contact), which makes them attractive for oral multiparticulate formulations of modified release. The presented solids were characterized with modern anal. methods and the relation between the material structure and desorption rate were discussed.

Microporous and Mesoporous Materials published new progress about Composites. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Application In Synthesis of 3290-92-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Yunxia; Chen, Hansen; Tsoi, Bun; Wang, Qi; Shen, Jiangang published the artcile< Danggui-Shaoyao-San (DSS) ameliorates cerebral ischemia-reperfusion injury via activating SIRT1 signaling and inhibiting NADPH oxidases>, Electric Literature of 112-63-0, the main research area is DSS cerebral ischemia reperfusion injury SIRT signaling NADPH oxidase; Danggui-Shaoyao-San; SIRT1; oxidative stress; peroxynitrite; stroke.

Danggui-Shayao-San (DSS) is a famous Traditional Chinese Medicine formula that used for treating pain disorders and maintaining neurol. health. Recent studies indicate that DSS has neuroprotective effects against ischemic brain damage but its underlining mechanisms remain unclear. Herein, we investigated the neuroprotective mechanisms of DSS for treating ischemic stroke. Adult male Sprague-Dawley (S.D.) rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) plus 22 h of reperfusion. Both ethanol extract and aqueous extract of DSS (12 g/kg) were orally administrated into the rats at 30 min prior to MCAO ischemic onset. We found that 1 ethanol extract of DSS, instead of aqueous extract, reduced infarct sizes and improved neurol. deficit scores in the post-ischemic stroke rats; 2 Ethanol extract of DSS down-regulated the expression of the cleaved-caspase 3 and Bax, up-regulated bcl-2 and attenuated apoptotic cell death in the ischemic brains; 3 Ethanol extract of DSS decreased the production of superoxide and peroxynitrite; 4 Ethanol extract of DSS significantly down-regulated the expression of p67phox but has no effect on p47phox and iNOS statistically. 5 Ethanol extract of DSS significantly up-regulated the expression of SIRT1 in the cortex and striatum of the postischemic brains; 6 Co-treatment of EX527, a SIRT1 inhibitor, abolished the DSS’s neuroprotective effects. Taken together, DSS could attenuate oxidative/nitrosative stress and inhibit neuronal apoptosis against cerebral ischemic-reperfusion injury via SIRT1-dependent manner.

Frontiers in Pharmacology published new progress about Animal gene, Bcl-2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Akram, Muhammad; Mei, Zhipeng; Shi, Jiayan; Wen, Jiayue; Khalid, Hamad; Jiang, Jiapei; Tian, Yanhong; Tian, Yanqing published the artcile< Electrospun nanofibers and spin coated films prepared from side-chain copolymers with chemically bounded platinum (II) porphyrin moieties for oxygen sensing and pressure sensitive paints>, Synthetic Route of 71195-85-2, the main research area is electrospun nanofiber spin coated film side chain copolymer; Fluorinated polymers; Nanofibers; Oxygen responses; Oxygen sensing; Pressure sensitive paints.

Pressure sensitive paints (PSP) containing oxygen probes were primarily used to measure air pressure. In this perspective, a polymerizable methacrylate-derived tetraphenylporphinato platinum(II) (PtTPP-MA) monomer was copolymerized with acrylic/vinyl monomers to produce four different copolymers. Octafluoropentyl methacrylate (OCFPM) and pentafluorophenyl acrylate (PFPA) were used as fluorinated monomers. Me methacrylate (MMA) and styrene (S) were used as non-fluorinated monomers. The structures and phys. properties of the polymers were confirmed by 1H NMR, 19F NMR, GPC, and DSC. Exptl. conditions were optimized to get fine nanofibers. Pressure sensing electrospun membranes and spin coated films were fabricated. Nanofibers showed fast response and good sensitivity towards gaseous oxygen. The influence of types of substrate and polymer natures on response time, oxygen sensitivity, and pressure responses were deliberated. Among our synthesized copolymers, poly(PS-co-PFPA-co-OCFPM-co-PtTPPMA) (Polymer P3) showed fast response time and good pressure sensitivity both as spin coated films and nanofibers.

Talanta published new progress about Acrylic fibers, fluorine-containing Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PROC (Process), PREP (Preparation), USES (Uses). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Synthetic Route of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Di; Ma, Lixue; Wu, Mengna; Wang, Xiaoyu; Xu, Lei; Yu, Qiaoru; Wang, Changyuan published the artcile< Effect of microbial communities on the quality characteristics of northeast soybean paste: Correlation between microorganisms and metabolites>, Computed Properties of 112-63-0, the main research area is soybean paste microorganism metabolite microbial community.

To systematically explore the impact of microbial community composition on the quality characteristics of northeast soybean paste, the microbial community structure was determined by high-throughput sequencing technol. and the flavor substance, free amino acid (FAA) and biogenic amine (BA) contents were determined by HS-SPME-GC-MS and HPLC. Furthermore, the correlation between microorganisms and metabolites was investigated. The results indicated that the core bacteria mainly included Tetragenococcus, Bacillus and Lactobacillus; Candida_f__norank, Wickerhamomyces and Aspergillus were the dominant fungi. A total of 139 flavor compounds were detected in all samples, and decamethylcyclopentasiloxane, isoamyl phenylacetate and octamethylcyclotetrasiloxane accounted for the highest proportion. A total of 24 FAAs were detected in the soybean paste. Pantoea, Kroppenstedtia and Kocuria were significantly pos. correlated with most FAAs (p < 0.05). Addnl. 5 BAs were detected in the soybean paste, and the contents of BAs in Y4 were highest, which was affected by different microbes. This study provided relevant information for the microbial community composition and metabolites of northeast soybean paste, which was of great significance for understanding the characteristics and safety of soybean paste. LWT--Food Science and Technology published new progress about Acaulium. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Skupinska, Krystyna A.; McEachern, Ernest J.; Skerlj, Renato T.; Bridger, Gary J. published the artcile< Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines>, Reference of 112-63-0, the main research area is aminotetrahydroquinoline aminotetrahydroisoquinoline preparation; hydrogenation acetamidoquinoline acetamidoisoquinoline; hydrolysis acetamidotetrahydroquinoline; regioselective reduction quinoline derivative.

A method to prepare amino-substituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of the corresponding acetamido-substituted quinolines and isoquinolines followed by acetamide hydrolysis is described. The yields of the products are good when the acetamido substituent is present on the pyridine ring and moderate with the acetamido substituent on the benzene ring. This method has also been applied to the regioselective reduction of quinoline substrates bearing other substituents (R = OMe, CO2Me, Ph).

Journal of Organic Chemistry published new progress about Hydrogenation, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rice, Scott; Cox, Daniel J.; Marsden, Stephen P.; Nelson, Adam published the artcile< Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating 'stitching' annulation approach>, Synthetic Route of 61367-16-6, the main research area is polycyclic compound preparation regioselective diastereoselective; amine arylation cyclization.

Regioselective and stereospecific directed C-H arylation of simple amine substrates e.g., exo-2-aminonorbornane, and cyclisation, delivered three-dimensional scaffolds e.g., (1R,3aR,4R,10bS)-2,3,3a,4,5,10b-hexahydro-1,4-methanobenzo[c]cyclopenta[e]azepin-6(1H)-one. The unified approach significantly expanded the range of bridged ring systems that contain both a nitrogen atom and an aromatic ring.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 61367-16-6 belongs to class esters-buliding-blocks, and the molecular formula is C8H16ClNO2, Synthetic Route of 61367-16-6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lewinski, Piotr; Kaluzynski, Krzysztof; Pretula, Julia; Mielniczak, Grazyna; Penczek, Stanislaw published the artcile< Catalysis in polymerization of cyclic esters. Catalyst and initiator in one molecule. Polymerization of lactide>, Related Products of 112-63-0, the main research area is lactide ring opening polymerization catalyst.

Poly(L-lactide) (PLA) was synthesized with initiator and catalyst in one mol. (CINICAT): 5-ethyl-2-hydroxy-5-hydroxymethyl-1,3,2-dioxaphosphorinane-2-oxide (GM). Polymerizations were conducted at the relatively high temperature (170-190°C) because of the low basicity of LA. Nevertheless, the studied processes were found to be living/controlled, no side reactions were determined and only PLA with fragments of GM as the end-groups were detected. PLA with Mn up to ∼40·103 g/mol. Kinetic studies indicated second order dependence of the rate of polymerization on the initial concentration of the CINICAT. This result is suggesting activation of the monomer and propagation with two independent macromols.

Journal of Catalysis published new progress about Cationic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Babichev, F. S.; Patratii, V. K.; Kovtunenko, V. A.; Prodanchuk, N. G.; Sinchenko, V. G.; Kisel, V. M. published the artcile< Synthesis and antimicrobial activity of 2-aryl-1,4-dihydroisoquinoline-3-imines>, Formula: C19H34O2, the main research area is bactericide aryldihydroisoquinoline imine derivative; fungicide aryldihydroisoquinoline imine derivative; antimicrobial aryldihydroisoquinoline imine derivative.

Reaction of o-(bromomethyl)phenylacetonitrile with aromatic amines gave rise to a number of hydrobromides of 2-aryl-1,4-dihydroisoquinoline-3-imines that were tested for their antimicrobial activity. The structure-activity relationship of the synthesized compounds is discussed.

Khimiko-Farmatsevticheskii Zhurnal published new progress about Fungicides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics