Month: October 2022

Wei, Xiao-Jing; Abdiaj, Irini; Sambiagio, Carlo; Li, Chenfei; Zysman-Colman, Eli; Alcazar, Jesus; Noel, Timothy published the artcile< Visible-Light-Promoted Iron-Catalyzed C(sp2)-C(sp3) Kumada Cross-Coupling in Flow>, Product Details of C19H34O2, the main research area is Kumada cross coupling aryl chloride Grignard reagent iron catalyst; visible light Kumada cross coupling iron catalyst mechanism flow; Kumada coupling; cross-coupling; flow chemistry; iron catalysis; photocatalysis.

A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application. The mechanism was studied using radical clock experiments, kinetic measurements, DFT and other techniques.

Angewandte Chemie, International Edition published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hatami, Behnam; Ebrahimi, Aliasghar; Ehrampoush, Mohammad Hassan; Salmani, Mohammad Hossein; Dalvand, Arash; Pirmoradi, Neda; Angelidaki, Irini; Fotidis, Ioannis A.; Mokhtari, Mehdi published the artcile< Recovery of intermittent cycle extended aeration system sludge through conversion into biodiesel by in-situ transesterification>, COA of Formula: C19H34O2, the main research area is fatty acid methyl ester sludge transesterification biodiesel synthesis.

The feasibility of using intermittent cycle extended aeration system (ICEAS) sludge as a lipid feedstock for biodiesel production was investigated. The main effects of in situ transesterification parameters, reaction temperature (30-70°C), reaction time (4-24 h), catalyst concentration (1-5% volume/volume), and proportion of methanol to dry sludge (5-25 mL/g) at five-levels as well as their simultaneous interactions were evaluated to develop an empirical model. Optimized conditions were obtained at 60°C, 4.65% (volume/volume) H2SO4, 17.84 h reaction time, and 5:1 methanol to dry sludge proportion (ml/g), leading to a maximum of 18.58% (weight/weight) biodiesel yield with 94.23% fatty acid Me ester content. This result was higher in comparison with yields derived from conventional activated sludge, membrane bioreactor and anaerobic-anoxic-oxic processes. The ICEAS technol. advantages are owned to its different configurations leading to production of one blended sludge, shorter hydraulic retention time and higher COD to nitrogen ratios. The predominance of fatty acid Me esters such as palmitic, oleic, palmitoleic, stearic, linoleic and myristic acid Me ester, in the obtained biodiesel, indicated suitability of ICEAS sludge as feedstock for biodiesel production

Renewable Energy published new progress about Aeration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kolekar, Yuvraj A.; Bhanage, Bhalchandra M. published the artcile< Pd-Catalyzed Oxidative Aminocarbonylation of Arylboronic Acids with Unreactive Tertiary Amines via C-N Bond Activation>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is amine tertiary arylboronic acid palladium catalyst aminocarbonylation bond activation; tertiary amide preparation.

An efficient synthesis of tertiary amides from aryl boronic acids and inert tertiary amines through the oxidative carbonylation via C(sp3)-N bond activation is presented. This protocol significantly restricts the homocoupling biarylketone product. It involves the use of a homogeneous PdCl2/CuI catalyst and a heterogeneous Pd/C based catalyst, which promotes C(sp3)-N bond activation of tertiary amines with aryl boronic acids. This process represents a ligand-free, base-free, and recyclable catalyst along with an ideal oxidant like mol. oxygen.

Journal of Organic Chemistry published new progress about Amides, tertiary Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Frelek, Jadwiga; Geiger, Marcela; Voelter, Wolfgang published the artcile< Absolute configurational assignment of α-hydroxy acids and α-hydroxy esters from their Cupra A circular dichroism spectra>, Formula: C6H10O5, the main research area is chiral alpha hydroxy acid absolute configuration Cotton effect; CD spectra Cupra A hydroxy acid chiral complex.

The in situ formed complexes of cuprammonium solution (Cupra A) with optically active α-hydroxy acids and α-hydroxy esters show CD spectra suitable for determination of the absolute configuration of both groups of compounds In the long wavelength spectral region, compounds of R configuration at the α carbon atom display a pos. Cotton effect of around 600 nm and a neg. one at ca. 720 nm, whereas (S)-α-hydroxy acids and esters exhibit neg. and pos. Cotton effects, resp., in the same spectral range.

Tetrahedron: Asymmetry published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beltzig, Lea; Christmann, Markus; Kaina, Bernd published the artcile< Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics>, Application In Synthesis of 112-63-0, the main research area is apoptosis; artesunate; cell death; cellular senescence; chloroquine; curcumin; fisetin; glioma; senolytics; temozolomide.

A first-line therapeutic for high-grade glioma, notably glioblastoma (GBM), is the DNA methylating drug temozolomide (TMZ). Previously, we showed that TMZ induces not only apoptosis and autophagy, but also cellular senescence (CSEN). We presented the hypothesis that GBM cells may escape from CSEN, giving rise to recurrent tumors. Furthermore, the inflammatory phenotype associated with CSEN may attenuate chemotherapy and drive tumor progression. Therefore, treatments that specifically target senescent cells, i.e., senolytic drugs, may lead to a better outcome of GBM therapy by preventing recurrences and tumor inflammation. Here, we tested Bcl-2 targeting drugs including ABT-737, ABT-263 (navitoclax), several natural substances such as artesunate, fisetin and curcumin as well as lomustine (CCNU) and ionizing radiation (IR) for their senolytic capacity in GBM cells. Addnl., several proteins involved in the DNA damage response (DDR), ATM, ATR, Chk1/2, p53, p21, NF-kB, Rad51, PARP, IAPs and autophagy, a pathway involved in CSEN induction, were tested for their impact in maintaining CSEN. Treatment of GBM cells with a low dose of TMZ for 8-10 days resulted in >80% CSEN, confirming CSEN to be the major trait induced by TMZ. To identify senolytics, we treated the senescent population with the compounds of interest and found that ABT-737, navitoclax, chloroquine, ATMi, ATRi, BV-6, PX-866 and the natural compounds fisetin and artesunate exhibit senolytic activity, inducing death in senescent cells more efficiently than in proliferating cells. Curcumin showed the opposite effect. No specific effect on CSEN cells was observed by inhibition of Chk1/Chk2, p21, NF-kB, Rad51 and PARP. We conclude that these factors neither play a critical role in maintaining TMZ-induced CSEN nor can their inhibitors be considered as senolytics. Since IR and CCNU did not exhibit senolytic activity, radio- and chemotherapy with alkylating drugs is not designed to eliminate TMZ-induced senescent cancer cells.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karunakaran, K.; Elango, K. P. published the artcile< Kinetics and mechanism of oxidation of (arylthio)acetic acids by pyridinium hydrobromide perbromide>, Synthetic Route of 112-63-0, the main research area is kinetics pyridinium hydrobromide perbromide arylthioacetic acid; oxidation pyridinium hydrobromide perbromide arylthioacetic acid; mechanism pyridinium hydrobromide perbromide arylthioacetic acid.

Oxidation of several monosubstituted (phenylthio)acetic acids (PTAA) by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid. The reaction is first order with respect to PHPB. Michaelis-Menten type kinetics are observed with respect to (arylthio)acetic acid. The effect of solvent composition indicates that the transition state is more polar than the reactants. The formation constants of the intermediate substrate-PHPB complexes and the rates of their decomposition were determined at different temperatures The rates of oxidation of para and meta-substituted (phenylthio)acetic acids were correlated with Hammett’s substituent constants The p value is -1:60 at 35°C. The rates of oxidation of ortho substituted compounds are correlated with Charton’s triparametric equation. A mechanism involving the decomposition of the intermediate complex in the slow rate-determining step affording a sulfonium ion which hydrolyses in a subsequent fast step to the sulfoxide is proposed.

Journal of Physical Organic Chemistry published new progress about Formation constant. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Musso, Loana; Cincinelli, Raffaella; Zuco, Valentina; De Cesare, Michelandrea; Zunino, Franco; Fallacara, Anna Lucia; Botta, Maurizio; Dallavalle, Sabrina published the artcile< 3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is arylidene hydroxyoxindole synthesis antitumor p53 apoptosis; N-hydroxyoxindole; antiproliferative activity; antitumor agents; apoptosis; p53.

A series of compounds containing the N-hydroxyoxindole scaffold were synthesized and evaluated for antitumor activity. The compounds showed potent antiproliferative activity against the wild-type p53 IGROV-1 ovarian carcinoma cell line and considerably lower efficacy against the mutant IGROV-1/Pt1 subline that lacks p53 function. The differential response of ovarian carcinoma cells depending on p53 status was also reflected in the varied susceptibility to apoptosis of the treated cell lines. These results support a role for the p53 transcription factor as a determinant of cytotoxicity. The therapeutic potential of the most promising compound of the series was evaluated in the treatment of an IGROV-1 xenograft growing as ascitic tumor in mice. Using i.p. administration, daily treatment with the compound for four weeks produced a significant delay in the onset of ascites.

ChemMedChem published new progress about Antitumor agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh, Adesh Kumar; Kandasamy, Jeyakumar published the artcile< Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature>, Reference of 4098-06-0, the main research area is palladium catalyzed stereoselective synthesis aryl glycoside glycal arenediazonium.

A stereocontrolled synthesis of aryl-C-glycosides was achieved using glycals and aryldiazonium salts in the presence of palladium acetate. A wide range of glycals including D-glucal, D-galactal, L-rhamnal, D-xylal and D-ribal underwent C-arylation at the anomeric carbon in the presence of different aryldiazonium tetrafluoroborates and gave synthetically useful 2,3-deoxy-3-keto-α-aryl-C-glycosides in good to excellent yields. Broad substrate scope, simple operation and room temperature reactions make this protocol very attractive in organic synthesis.

Organic & Biomolecular Chemistry published new progress about Arylation catalysts, stereoselective. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Reference of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Toshima, Hiroaki; Saito, Masatoshi; Yoshihara, Teruhiko published the artcile< Total synthesis of (+)-(2S,3R)-Piscidic acid via catalytic asymmetric dihydroxylation of a trisubstituted olefin>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is catalysis asym dihydroxylation trisubstituted olefin; piscidic acid total synthesis; asymmetric dihydroxylation; catalytic asymmetric synthesis; piscidic acid.

(+)-(2S,3R)-Piscidic acid was efficiently synthesized with high optical purity (90% e.e.) via Sharpless catalytic asym. dihydroxylation of a trisubstituted olefin in only 6 steps from com. available 4-hydroxyphenyl-pyruvic acid as the starting material. The reaction proceeded with high optical purity by using the chiral ligands, dihydroquinidine 2,5-diphenyl-4,6-pyrimidinediyl diether or dihydroquinidine 1,4-anthraquinonediyl diether.

Bioscience, Biotechnology, and Biochemistry published new progress about Dihydroxylation (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Di; Chang, Shiquan; Li, Xin; Shi, Huimei; Jing, Bei; Chen, Zhenni; Lin, Yi; Zheng, Yachun; Qian, Guoqiang; Pan, Yuwei; Zhao, Guoping published the artcile< Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis>, SDS of cas: 112-63-0, the main research area is mecobalamin neuroprotectant sciatic nerve chronic constriction injury; Schwann cells; TLR4/NF-kB; chronic constriction injury; chronic neuralgia; paeoniflorin; sciatica.

Therapeutic drugs of chronic neuralgia have a high risk of addiction, making it crucial to identify novel drugs for chronic neuralgia. This study aimed to explore the therapeutic effect of paeoniflorin on chronic sciatica via inhibiting Schwann cell apoptosis. 28 SD rats were randomly divided into four groups, including the sham operation group, chronic constriction injury (CCI) group, mecobalamin group, and paeoniflorin group. The therapeutic effect and mechanism of paeoniflorin were evaluated via rat and cell experiments Mech., hot, or cold hyperalgesia was induced in the rats after CCI operation, while paeoniflorin relieved chronic neuralgia. Besides, paeoniflorin decreased the levels of IL1, IL6, TNF-α, CRP, and LPS and increased the level of IL10 in serum. As for the sciatic nerve, the number of inflammatory cells was decreased, and Schwann cells were present after paeoniflorin treatment, and paeoniflorin promoted the recovery of nerve structure. In cell experiments, LPS induced Schwann cell apoptosis via the TLR4/NF-kB pathway. And paeoniflorin attenuated LPS-induced Schwann cell apoptosis by decreasing the levels of TLR4, p-NF-kB, caspase3, cleaved-caspase3, and cleaved-caspase7. Overall, these results suggest that paeoniflorin alleviates chronic sciatica by decreasing inflammatory factor levels and promotes the repair of damaged nerves by reducing Schwann cell apoptosis.

Phytotherapy Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics