Month: October 2022

de Marcellus, Charles; Tauziede-Espariat, Arnault; Cuinet, Aurelie; Pasqualini, Claudia; Robert, Matthieu P.; Beccaria, Kevin; Puget, Stephanie; Boddaert, Nathalie; Figarella-Branger, Dominique; De Carli, Emilie; Bourdeaut, Franck; Leblond, Pierre; Fouyssac, Fanny; Andre, Nicolas; Bertozzi, Anne I.; Butel, Thibaut; Dufour, Christelle; Valteau-Couanet, Dominique; Varlet, Pascale; Grill, Jacques published the artcile< The role of irinotecan-bevacizumab as rescue regimen in children with low-grade gliomas: a retrospective nationwide study in 72 patients>, Quality Control of 112-63-0, the main research area is irinotecan bevacizumab anticancer agent KIAA1549 low grade glioma children; Bevacizumab; Children; Irinotecan; Low grade glioma.

At least half of children with low-grade glioma (LGG) treated with first line chemotherapy experience a relapse/progression and may therefore need a second-line chemotherapy. Irinotecan-bevacizumab has been recommended in this setting in France after encouraging results of pilot studies. We performed a retrospective anal. to define the efficacy, toxicity and predictors for response to the combination on a larger cohort. We reviewed the files from children < 19 years of age with progressive or refractory LGG treated between 2009 and 2016 in 7 French centers with this combination. In 72 patients (median age 7.8 years [range 1-19]) received a median of 16 courses (range 3-30). The median duration of treatment was 9 mo (range 1.4-16.2). 96% of patients experienced at least disease stabilization. The 6-mo and 2-yr progression-free survivals (PFS) were 91.7% [IC 95% 85.5-98.3] and 38.2% [IC 95% 28.2-51.8] resp. No progression occurred after treatment in 18 patients with a median follow-up of 35.6 mo (range 7.6-75.9 mo). Younger patients had a worse PFS (p = 0.005). Prior chemoresistance, NF1 status, duration of treatment, histopathol. or radiol. response did not predict response. The most frequent toxicities related to bevacizumab included grades 1-2 proteinuria in 21, epistaxis in 10, fatigue in 12 and hypertension in 8 while gastro-intestinal toxicity was the most frequent side effect related to irinotecan. Bevacizumab-irinotecan has the potential of disease control clin. and radiog. in children with recurrent LGG whatever their previous characteristics; in many cases however these responses are not sustained, especially in younger children. Journal of Neuro-Oncology published new progress about Aging, animal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Li; Yang, Yue; Si, Lu; Chi, Zhihong; Sheng, Xinan; Lian, Bin; Wang, Xuan; Tang, Bixia; Mao, Lili; Yan, Xieqiao; Li, Siming; Bai, Xue; Guo, Jun; Cui, Chuanliang published the artcile< Phase II study of apatinib combined with temozolomide in patients with advanced melanoma after failure of immunotherapy>, Application In Synthesis of 112-63-0, the main research area is .

Treatment for advanced melanoma after progression on immunotherapy is limited. This phase II trial (NCT03422445) was conducted to evaluate the efficacy and safety of apatinib plus temozolomide in patients with advanced melanoma after failure of immunotherapy. Patients with unresectable stage III or stage IV melanoma after progression on immunotherapy were treated with temozolomide 300 mg on days 1-5 and apatinib 500 mg daily every 28-day cycle until disease progression or intolerable toxicities. Besides immunotherapy, prior chemotherapy, targeted therapy, and clin. trials were allowed. The primary endpoint was progression-free survival. Secondary endpoints were objective response rate, disease control rate, overall survival, and safety. Of 29 patients, 28 (96.6%) had metastatic diseases, and the predominant subtypes were mucosal [12 (41.4%)] and acral melanoma [eight (27.6%)]. Five (17.2%) patients showed BRAF, CKIT, or NRAS mutation. Five achieved confirmed partial response, with an objective response rate of 17.2%. The disease control rate was 82.8%. The median progression-free survival was 5.0 mo [95% confidence interval (CI): 4.7-5.3], and the median overall survival was 10.1 mo (95% CI: 5.1-15.0). Grade 3-4 treatment-related adverse events included proteinuria [four (13.8%)], thrombocytopenia [two (6.9%)], hypertension [one (3.4%)], and hyperbilirubinemia [one (3.4%)]. No treatment-related death occurred. Apatinib plus temozolomide demonstrated promising efficacy and manageable safety profile in patients with advanced melanoma after progression on immunotherapy.

Melanoma Research published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Jung Ho; Jiamsakul, Awachana; Kiertiburanakul, Sasisopin; Huy, Bui Vu; Khusuwan, Suwimon; Kumarasamy, Nagalingeswaran; Ng, Oon Tek; Ly, Penh Sun; Lee, Man-Po; Chan, Yu-Jiun; Gani, Yasmin Mohamed; Azwa, Iskandar; Avihingsanon, Anchalee; Merati, Tuti Parwati; Pujari, Sanjay; Chaiwarith, Romanee; Zhang, Fujie; Tanuma, Junko; Do, Cuong Duy; Ditangco, Rossana; Yunihastuti, Evy; Ross, Jeremy; Choi, Jun Yong; on behalf of IeDEA Asia-Pacific published the artcile< Patterns and prognosis of holding regimens for people living with HIV in Asian countries>, Application In Synthesis of 112-63-0, the main research area is lamivudine zidovudine antiretroviral agent prognosis HIV infection.

The use of holding regimens for people living with HIV (PLWH) without effective antiretroviral options can have effects on outcomes and future treatment options. We aimed to investigate the use of holding regimens for PLWH in Asian countries. Data from adults enrolled in routine HIV care in IeDEA Asia-Pacific cohorts were included. Individuals were considered to be on holding regimen if they had been on combination antiretroviral therapy for at least 6 mo, had two confirmed viral loads (VL) ≥1000 copies/mL, and had remained on the same medications for at least 6 mo. Survival time was analyzed using Fine and Gray’s competing risk regression. Factors associated with CD4 changes and VL <1000 copies/mL were analyzed using linear regression and logistic regression, resp. A total of 425 PLWH (72.9% male; 45.2% high-income and 54.8% low-to-middle-income country) met criteria for being on a holding regimen. From high-income countries, 63.0% were on protease inhibitors (PIs); from low-to-middle-income countries, 58.4% were on non-nucleoside reverse transcriptase inhibitors (NNRTIs); overall, 4.5% were on integrase inhibitors. The combination of lamivudine, zidovudine, and efavirenz was the most commonly used single regimen (n = 46, 10.8%), followed by lamivudine, zidovudine, and nevirapine (n = 37, 8.7%). Forty-one PLWH (9.7%) died during follow-up (mortality rate 2.0 per 100 person-years). Age >50 years compared to age 31-40 years (sub-hazard ratio [SHR] 3.29, 95% CI 1.45-7.43, p = 0.004), and VL ≥1000 copies/mL compared to VL <1000 copies/mL (SHR, 2.14, 95% CI 1.08-4.25, p = 0.029) were associated with increased mortality, while higher CD4 counts were protective. In our Asia regional cohort, there was a diversity of holding regimens, and the patterns of PI vs. NNRTI use differed by country income levels. Considering the high mortality rate of PLWH with holding regimen, efforts to extend accessibility to addnl. antiretroviral options are needed in our region. PLoS One published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dash, Pragyanditi; Janni, Manojkumar; Peruncheralathan, S. published the artcile< Trideuteriomethoxylation of Aryl and Heteroaryl Halides>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is trideuteriomethoxylation aryl heteroaryl halide perdeuteriomethanol palladium catalyst; ether trideuteriomethyl preparation.

Direct access to trideuteriomethoxylated aromatic and heteroaromatic compounds has been developed. Various aryl and heteroaryl halides underwent d3-methoxylation under mild reaction conditions by using a catalyst system composed of the com. available monodentate phosphane ligand tBuXPhos and Pd(OAc)2. Inexpensive CD3OD served as an efficient trideuteriomethoxylating agent.

European Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

di Bitonto, Luigi; Locaputo, Vito; D’Ambrosio, Valeria; Pastore, Carlo published the artcile< Direct Lewis-Bronsted acid ethanolysis of sewage sludge for production of liquid fuels>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is liquid fuel sewage sludge ethanolysis catalytic wastewater treatment.

Ethanolysis carried out under Lewis-Bronsted acid catalysis was investigated as a possible process to valorize the organic fraction of urban sewage sludge, with the aim of selectively obtaining liquid biofuels. In a single reactive step, the conversion of lipids into fatty acid Et esters, of carbohydrates into Et levulinate, furanic compounds and Et glycosides and of proteins into Et ester of amino acids was achieved. The optimization of reactive conditions was conducted using pure chems. as model compounds The effect of the co-presence of water was also considered. Then, real samples of sewage sludge (as dried and wet centrifuged samples) were reacted in ethanol in the presence of the appropriate combination of homogeneous Lewis-Bronsted acid catalysts, namely 1%wt aluminum chloride hexahydrate and sulfuric acid respect to ethanol. After 6 h at 453 K, 99% of lipids and almost 60% of initial complex sugars were effectively converted into the abovementioned target products. Conversions and yields were quite similar to those obtained by reacting pure compounds singularly, confirming the robustness of the process and its applicability to differently composed sludge. At the end of the reaction, products were easily recovered and purified from the alc. phase, whereas only a very limited amount of solids remain as inert materials. Final refined biofuels have high calorific values (37 and 40 MJ kg-1) and actually represent the 68.5 and 59.2% of the initial energy content of starting sludge, resp. This strategy combines valorization of the starting organic fraction of sewage sludge and a considerable reduction of final solid waste (in a stabilized form) to be disposed of. Finally, through a preliminary feasibility study, this acid ethanolysis resulted in a competitive alternative to the anaerobic digestion of mixed sewage sludge to obtain biofuels.

Applied Energy published new progress about Biofuels. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Bongyong; Mohamad, Iqbal; Pokhrel, Rudramani; Murad, Rabi; Yuan, Menglang; Stapleton, Stacie; Bettegowda, Chetan; Jallo, George; Eberhart, Charles G.; Garrett, Timothy; Perera, Ranjan J. published the artcile< Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is RNA lipid cerebrospinal fluid hypoxia medulloblastoma; Circular RNA; Lipidomics; Medulloblastoma; Metabolomics; TCA; Transcriptomics.

Medulloblastoma (MB) is the most common malignant brain tumor in children. There remains an unmet need for diagnostics to sensitively detect the disease, particularly recurrences. Cerebrospinal fluid (CSF) provides a window into the central nervous system, and liquid biopsy of CSF could provide a relatively non-invasive means for disease diagnosis. There has yet to be an integrated anal. of the transcriptomic, metabolomic, and lipidomic changes occurring in the CSF of children with MB. CSF samples from patients with (n = 40) or without (n = 11; no cancer) MB were subjected to RNA-sequencing and high-resolution mass spectrometry to identify RNA, metabolite, and lipid profiles. Differentially expressed transcripts, metabolites, and lipids were identified and their biol. significance assessed by pathway anal. The DIABLO multivariate anal. package (R package mixOmics) was used to integrate the mol. changes characterizing the CSF of MB patients. Differentially expressed transcripts, metabolites, and lipids in CSF were discriminatory for the presence of MB but not the exact mol. subtype. One hundred and ten genes and ten circular RNAs were differentially expressed in MB CSF compared with normal, representing TGF-β signaling, TNF-α signaling via NF-kB, and adipogenesis pathways. Tricarboxylic acid cycle and other metabolites (malate, fumarate, succinate, α-ketoglutarate, hydroxypyruvate, N-acetyl-aspartate) and total triacylglycerols were significantly upregulated in MB CSF compared with normal CSF. Although separating MBs into subgroups using transcriptomic, metabolomic, and lipid signatures in CSF was challenging, we were able to identify a group of omics signatures that could sep. cancer from normal CSF. Metabolic and lipidomic profiles both contained indicators of tumor hypoxia. Our approach provides several candidate signatures that deserve further validation, including the novel circular RNA circ_463, and insights into the impact of MB on the CSF microenvironment.

Acta Neuropathologica Communications published new progress about 14-3-3 Protein YWHAG Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Knight, Steven D.; Adams, Nicholas D.; Burgess, Joelle L.; Chaudhari, Amita M.; Darcy, Michael G.; Donatelli, Carla A.; Luengo, Juan I.; Newlander, Ken A.; Parrish, Cynthia A.; Ridgers, Lance H.; Sarpong, Martha A.; Schmidt, Stanley J.; Van Aller, Glenn S.; Carson, Jeffrey D.; Diamond, Melody A.; Elkins, Patricia A.; Gardiner, Christine M.; Garver, Eric; Gilbert, Seth A.; Gontarek, Richard R.; Jackson, Jeffrey R.; Kershner, Kevin L.; Luo, Lusong; Raha, Kaushik; Sherk, Christian S.; Sung, Chiu-Mei; Sutton, David; Tummino, Peter J.; Wegrzyn, Ronald J.; Auger, Kurt R.; Dhanak, Dashyant published the artcile< Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin>, Formula: C19H34O2, the main research area is cancer PI3K inhibitor antitumor agent quinoline derivative SAR preparation; GSK2126458; PI3K/AKT pathway; mammalian target of rapamycin; phosphoinositide 3-kinase α.

Phosphoinositide 3-kinase α (PI3Kα) is a critical regulator of cell growth and transformation, and its signaling pathway is the most commonly mutated pathway in human cancers. The mammalian target of rapamycin (mTOR), a class IV PI3K protein kinase, is also a central regulator of cell growth, and mTOR inhibitors are believed to augment the antiproliferative efficacy of PI3K/AKT pathway inhibition. 2,4-Difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide (GSK2126458, 1 (I)) has been identified as a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models. Compound 1 is currently being evaluated in human clin. trials for the treatment of cancer.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Jingyan; Ji, Xiaoming; Hao, Shuai; Zhao, Mingqin; Lai, Miao; Ren, Tianbao; Xi, Gaolei; Wang, Erbin; Wang, Juanjuan; Wu, Zhiyong published the artcile< Regioselective C-H sulfenylation of N-sulfonyl protected 7-azaindoles promoted by TBAI: a rapid synthesis of 3-thio-7-azaindoles>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is thioazaindole regioselective preparation; chloride sulfonyl protected azaindole TBAI CH sulfenylation.

This paper described the synthesis of 3-thio-7-azaindoles I [R1 = H, 2-Me, 5-Cl, 5-Br, 2-I; R2 = Ph, 4-FC6H4, 4-MeC6H4, etc.] via regioselective C-3 sulfenylation of N-sulfonyl protected 7-azaindoles with sulfonyl chlorides. In this transformation, dual roles of TBAI served as both promoter and desulfonylation reagent was demonstrated. The reaction proceeded smoothly under simple conditions to afford 3-thio-7-azaindoles I in moderate to good yields with broad substrate scopes. This protocol refrained from the use of transition-metal catalysts, strong oxidants or bases and showed its practical synthetic value in organic synthesis.

RSC Advances published new progress about Arenesulfonyl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wen, Zhe; Ma, Zewei; Mai, Fuhang; Yan, Fei; Yu, Linhao; Jin, Meng; Sang, Yushuai; Bai, Yunfei; Cui, Kai; Wu, Kai; Chen, Mengmeng; Chen, Hong; Li, Yongdan published the artcile< Catalytic ethanolysis of microcrystalline cellulose over a sulfonated hydrothermal carbon catalyst>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is catalytic ethanolysis microcrystalline cellulose sulfonated hydrothermal carbon catalyst.

The catalytic ethanolysis of microcrystalline cellulose in supercritical ethanol is examined over a sulfonated hydrothermal carbon catalyst (SHTC). SHTC is amorphous carbon containing -OH, -COOH and -SO3H groups with total acidity of 7.15 mmol/g and -SO3H acidity of 1.72 mmol/g. SHTC shows high catalytic activity towards the ethanolysis of cellulose in supercritical ethanol. Complete conversion of microcrystalline cellulose with high yields of Et levulinate and Et glucoside is obtained. The reaction temperature, time and catalyst amount have significant effects on the catalytic performances of SHTC. Appropriate reaction time and less catalyst amount are favorable for the production of Et glucoside, while prolonged reaction time and appropriate catalyst amount favor the production of Et levulinate. The highest yield of Et glucoside as 420.9 mg/g cellulose is obtained over 0.1 g SHTC at 245°C for 1 h. The highest yield of Et levulinate as 817.6 mg/g cellulose is achieved over 0.3 g SHTC at 245°C for 1 h. SHTC shows good stability in the recycle experiments with slight loss of catalytic activity.

Catalysis Today published new progress about Ethanolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Ding-Li; Hu, Yi-Kao; Wang, Ji-Hua; Zhao, Yan; Huang, Yu-Ping; Zeng, Gui-Jun; Zhao, Yong published the artcile< A New Monoterpenoid Glycoside from Syzygium fluviatile>, Synthetic Route of 112-63-0, the main research area is Syzygium Fluviaterpenoside monoterpenoid glycoside.

A new monoterpenoid glycoside, together with seven known aliphatic acid derivatives, was isolated from the twigs and leaves of Syzygium fluviatile. Their structures were elucidated by means of NMR and HR-ESI-MS data and comparison with the reported values. This is the first example of a monoterpenoid glycoside from Syzygium plants.

Chemistry of Natural Compounds published new progress about Leaf. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics