Month: October 2022

Zhang, Zhaoqiang; Kang, Chengjun; Peh, Shing Bo; Shi, Dongchen; Yang, Fengxia; Liu, Qixing; Zhao, Dan published the artcile< Efficient Adsorption of Acetylene over CO2 in Bioinspired Covalent Organic Frameworks>, Formula: C19H34O2, the main research area is adsorption acetylene CO2 bioinspired covalent organic framework.

Rational design of covalent organic frameworks (COFs) to broaden their diversity is highly desirable but challenging due to the limited, expensive, and complex building blocks, especially compared with other easily available porous materials. In this work, we fabricated two novel bioinspired COFs, namely, NUS-71 and NUS-72, using reticular chem. with ellagic acid and triboronic acid-based building blocks. Both COFs with AB stacking mode exhibit high acetylene (C2H2) adsorption capacity and excellent separation performance for C2H2/CO2 mixtures, which is significant but rarely explored using COFs. The impressive affinities for C2H2 appear to be related to the sandwich structure formed by C2H2 and the host framework via multiple host-guest interactions. This work not only represents a new avenue for the construction of low-cost COFs but also expands the variety of the COF family using natural biochems. as building blocks for broad application.

Journal of the American Chemical Society published new progress about Adsorbents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bruvers, Z.; Zuika, I. published the artcile< SCF MO calculations of quinoline and its derivatives. 3. Energy of protonation and basic properties>, Computed Properties of 112-63-0, the main research area is protonation quinoline substituent effect MO; electron configuration quinoline derivative; bond energy protonated quinoline derivative.

The protonation energy (E), N charge, N-H bond energy, and pKNH+ were calculated for quinoline and its NH2, MeO, MeS, and other derivatives by the CNDO/2 method. In quinolines substituted at the 3-, 4-, 5-, 6-, and 7-positions, E and pKNH+ were determined mainly by the interaction of the substituent with the heterocyclic system. 2-Substituted quinolines exhibited steric effects, and 8-substituted quinolines showed H-bonding effects.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about Basicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zampella, Angela; Bassarello, Carla; Bifulco, Giuseppe; Gomez-Paloma, Luigi; D’Auria, Maria Valeria published the artcile< Stereochemistry of sphinxolides and reidispongiolides. Asymmetric synthesis of the C17-C22 fragment of reidispongiolide A>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is reidispongiolide absolute stereochem fragment preparation ozonolysis; asym synthesis hexanetetraol derivative.

Five fragments, [I (R = α, β-OH), II, III (R = α, β-OH)] embedding all the stereogenic centers of reidispongiolide A (IV), have been prepared by a controlled ozonolysis of the IV. The absolute stereochem. of the asym. centers of II, corresponding to the C17-C22 portion of IV, was determined by enantioselective synthesis and application of the advanced Mosher method.

European Journal of Organic Chemistry published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Zhi; Qiao, Jing; Nagy, Tamas; Xiong, May P. published the artcile< ROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo>, Reference of 71195-85-2, the main research area is ROS responsive polymeric deferoxamine nanogel iron chelation therapy; Chelation therapy; Deferoxamine (DFO); Iron overload (IO); Nanogel; Reactive oxygen species (ROS).

Iron-mediated generation of highly toxic Reactive Oxygen Species (ROS) plays a major role in the process leading to iron overload-related diseases. The long-term s.c. administration of Deferoxamine (DFO) is currently clin.-approved to improve patient symptoms and survival. However, non-specific toxicity and short circulation times of the drug in humans often leads to poor patient compliance. Herein, thioketal-based ROS-responsive polymeric nanogels containing DFO moieties (rNG-DFO) were designed to chelate iron and to degrade under oxidative stimuli into fragments <10 nm to enhance excretion of iron-bound chelates. Serum ferritin levels and iron concentrations in major organs of IO mice decreased following treatment with rNG-DFO, and fecal elimination of iron-bound chelates increased compared to free DFO. Furthermore, rNG-DFO decreased iron mediated oxidative stress levels in vitro and reduced iron-mediated inflammation in the liver of IO mice. The study confirms that ROS-responsive nanogels may serve as a promising alternative to DFO for safer and more efficient iron chelation therapy. Journal of Controlled Release published new progress about Chelation. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shuai, Shu-Yuan; Liu, Shan-Shan; Liu, Xiao-Jin; Zhang, Guo-Song; Zheng, Qin; Yue, Peng-Fei; Yang, Ming; Hu, Peng-Yi published the artcile< Essential oil of Ligusticum chuanxiong Hort. Regulated P-gp protein and tight junction protein to change pharmacokinetic parameters of temozolomide in blood, brain and tumor.>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Essential oil of Ligusticum chuanxiong Hort.; Glioma; P-gp; Pharmacokinetics; Temozolomide; Tight junction.

ETHNOPHARMACOLOGICAL RELEVANCE: The existence of the blood-brain barrier/blood tumor barrier (BBB/BTB) severely restricts the effectiveness of anti-tumor drugs, thus glioma is still an incurable disease with a high fatality rate. Chuanxiong (Ligusticum chuanxiong Hort., Umbelliferae) was used as a messenger drug to increase the distribution of drugs in brain tissue, and its application in Chinese herbal formula for treating glioma was also the highest. AIM OF THE STUDY: Our previous researches showed that essential oil (EO) of chuanxiong could promote temozolomide (TMZ) entry into glioma cells in vitro and enhance TMZ-induced anticancer efficiency in vivo, and therefore, the aim of this study was to investigate whether EO could increase the concentration accumulation of TMZ in brain or tumor of C6 glioma rats and the related mechanisms. MATERIALS AND METHODS: The pharmacokinetics were conducted in C6 glioma rats by administering either TMZ alone or combined with EO through oral routes. TMZ concentration in blood, brain and tumor was detected using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) and then pharmacokinetic parameters were calculated. The changed expressions of P-gp protein, tight junction occludin, claudin-5 and zonula occludens-1 (ZO-1) in brain of glioma rats were studied by Western blot to clarify the mechanism. Finally, the chemical composition of EO was analyzed by gas chromatography-massspectrometry (GC-MS). RESULTS: The results showed that EO significantly affected the pharmacokinetic parameters such as Tmax, Cmax and CL (p < 0.01), but did not significantly change the AUC(0→∞) of TMZ in blood (p > 0.05). However, EO markedly improved the AUC(0→∞)of TMZ in brain and tumor (p < 0.01). The calculate drug targeting index was greater than 1, indicating that EO could promote the distribution of TMZ to the brain and tumor. Western blot analysis showed that EO significantly inhibited the expression of P-gp, tight junction protein claudin-5, occludin and ZO-1. And meanwhile, the expressions of P-gp, claudin-5 and occludin also markedly down-regulated in EO-TMZ co-administration treatment. GC-MS analysis of the TIC component of EO was (E)-Ligustilide (36.93%), Terpinolene (7.245%), gamma-terpinene (7.225%) etc. CONCLUSION: EO could promote the distribution of TMZ in the brain and tumor of C6 glioma rats, which may attribute to down-regulate the expression of P-gp, claudin-5 and occludin. Journal of ethnopharmacology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Bin; Meng, Xiang; Ma, Yanfang; Li, Huizhen; Liu, Yuqi; Shi, Nannan; Chen, Yaolong; Wang, Yanping; Lu, Cheng published the artcile< Clinical safety of total glucosides of paeony adjuvant therapy for rheumatoid arthritis treatment: a systematic review and meta-analysis>, Electric Literature of 112-63-0, the main research area is meta analysis methotrexate antiinflammatory rheumatoid arthritis; Adjuvant therapy; Clinical safety; Meta-analysis; Rheumatoid arthritis; Systematic review; Total glucosides of paeony.

Total glucosides of paeony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pallas, has been increasingly used as the adjunctive therapy for rheumatoid arthritis (RA) patients. Though TGP could mitigate the unanticipated adverse effects during the conventional treatment of RA, high-quality evidence-based meta-anal. data on this subject are still insufficient. The objective of this study is to evaluate the clin. safety of TGP adjuvant therapy in the RA treatment. PubMed, EMBASE, Web of Science, China Network Knowledge Infrastructure (CNKI), SinoMed and WanFang Data were retrieved for randomized controlled trials (RCTs) and cohort study about TGP adjuvant therapy in patients with RA up to 28 Jan. 2021. Literatures with eligibility criteria and information were screened and extracted by two researchers independently. The RevMan5.3 software was used for data anal. with effect estimates as risk ratio (RR) with 95% confidence interval (CI). A total of 39 studies involving 3680 RA participants were included. There were 8 comparisons: TGP plus methotrexate (MTX) therapy vs. MTX therapy, TGP plus leflunomide (LEF) therapy vs. LEF therapy, TGP plus MTX and LEF therapy vs. MTX plus LEF therapy, TGP plus tripterygium glycosides (TG) therapy vs. TG therapy, TGP plus meloxicam (MLX) therapy vs. MLX therapy and TGP plus sulfasalazine (SSZ) therapy vs. SSZ therapy, TGP plus iguratimod (IGU) therapy vs. IGU therapy, TGP plus prednisone acetate tablets (PAT) therapy vs. PAT therapy. The meta-anal. results showed that the occurrence of hepatic adverse effect (RR = 0.31, 95% CI = 0.23-0.41, P < 0.00001) and leukopenia (RR = 0.41, 95% CI = 0.26-0.66, P = 0.0002) in TGP adjuvant therapy was significant decreased compared with non-TGP therapy. However, only TGP plus LEF therapy (RR = 0.22, 95% CI = 0.08-0.60, P = 0.003) and TGP plus MTX and LEF therapy (RR = 0.31, 95% CI = 0.22-0.42, P < 0.00001) had statistical difference in the subgroups of hepatic adverse effect. In leukopenia, TGP plus MTX and LEF therapy (RR = 0.47, 95% CI = 0.25-0.87, P = 0.02) had statistical difference. This meta-anal. indicated that TGP adjuvant therapy might alleviate the incidence of hepatic adverse effect and leukopenia for the RA treatment compared to non-TGP therapy. The clin. safety of TGP adjuvant therapy warrant further investigation in exptl. studies. BMC Complementary Medicine and Therapies published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Branco, Luis C.; Serbanovic, Ana; Nunes da Ponte, Manuel; Afonso, Carlos A. M. published the artcile< Clean osmium-catalyzed asymmetric dihydroxylation of olefins in ionic liquids and supercritical CO2 product recovery>, Application In Synthesis of 112-63-0, the main research area is asym dihydroxylation olefin ionic liquid osmium catalyst.

The combination of ionic liquids (ILs) as solvents in the asym. Sharpless dihydroxylation (AD) with the use of scCO2 in the separation process allows a simple, efficient, clean and robust system for the reuse of the AD catalytic system, which also does not need the use of organic solvents either for the reaction or for the separation of products and allows the isolation of the diol, in high yield and enantiomeric excess and basically without contamination with osmium. The AD reaction was performed with the substrates 1-hexene and styrene, using the catalytic system consisting of (DHQD)2PHAL (1.0 mol% ) and K2OsO2(OH)4 (0.5 mol% ) and the co-oxidants K3Fe(CN)6 and N-methylmorpholine oxide (NMO). Under these conditions, a range of ILs based on the methylimidazolium (mim), dimethylimidazolium (bdmim) and tetraalkyldimethylguanidinium (dmg) cations were screened.

Chemical Communications (Cambridge, United Kingdom) published new progress about Dihydroxylation catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

DerSarkissian, Maral; Bhak, Rachel H.; Oglesby, Alan; Priest, Julie; Gao, Emily; Macheca, Monica; Sharperson, Camara; Duh, Mei Sheng published the artcile< Retrospective analysis of comorbidities and treatment burden among patients with HIV infection in a US Medicaid population>, Formula: C19H34O2, the main research area is HIV infection cardiovascular disease hypertension asthma comorbidity antiretroviral therapy; Antiretroviral therapy; HIV burden; comorbidity; concomitant medication; pill burden.

Comorbidities and comedications are important factors influencing optimal therapy because people are living longer with HIV infection. This study describes the long-term comorbidity profile and treatment burden among people with HIV-1 infection. This retrospective study included Medicaid claims data from patients with ≥1 antiretroviral (ARV) claim between 2016 and 2017 (most recent claim defined the index date), ≥1 HIV diagnosis within 1 yr before index, age ≥18 years at first HIV diagnosis and <65 years at index, ≥12 mo of continuous eligibility before index, and no history of HIV-2 infection. Comorbidities, concomitant medication use, and pill burden were assessed in the 4 years before index. Analyses were stratified by patient age and treatment experience. Among 3456 patients, the mean (standard deviation [SD]) age was 47.1 (10.4) years; the majority were black (55%) and men (63%). In general, the prevalence of comorbidities increased from the fourth year to the first year before index and included cardiovascular disease (28-40%), hypertension (24-37%), hyperlipidemia (12-17%), and asthma/chronic obstructive pulmonary disease (13-19%). Concomitant medication use corresponding to these comorbidities slightly increased over time. In the year before index, mean (SD) daily pill burden was 2.1 (1.4) for ARVs and 5.9 (5.9) for non-ARVs. Older age and prior treatment experience were associated with higher rates of comorbidities and greater pill burden. In people with HIV infection, comorbidities and concomitant medication use increased with age, supporting considerations for streamlined ARV regimens highlighted in treatment guidelines. Current Medical Research and Opinion published new progress about Aging, animal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Westerhaus, Felix A.; Jagadeesh, Rajenahally V.; Wienhoefer, Gerrit; Pohl, Marga-Martina; Radnik, Joerg; Surkus, Annette-Enrica; Rabeah, Jabor; Junge, Kathrin; Junge, Henrik; Nielsen, Martin; Brueckner, Angelika; Beller, Matthias published the artcile< Heterogenized cobalt oxide catalysts for nitroarene reduction by pyrolysis of molecularly defined complexes>, Computed Properties of 112-63-0, the main research area is aromatic amine preparation; hydrogenation nitroarene heterogeneous cobalt oxide catalyst.

Molecularly well-defined homogeneous catalysts are known for a wide variety of chem. transformations. The effect of small changes in mol. structure can be studied in detail and used to optimize many processes. However, many industrial processes require heterogeneous catalysts because of their stability, ease of separation, and recyclability, but these are more difficult to control on a mol. level. Here, we describe the conversion of homogeneous cobalt complexes into heterogeneous cobalt oxide catalysts via immobilization and pyrolysis on activated carbon. The catalysts thus produced are useful for the industrially important reduction of nitroarenes to anilines. The ligand indirectly controls the selectivity and activity of the recyclable catalyst and catalyst optimization can be performed at the level of the solution-phase precursor before conversion into the active heterogeneous catalyst.

Nature Chemistry published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Grosmann, Mikkel T.; Andrade, Thalles A.; Bitonto, Luigi di; Pastore, Carlo; Corazza, Marcos L.; Tronci, Stefania; Errico, Massimiliano published the artcile< Hydrated metal salt pretreatment and alkali catalyzed reactive distillation: A two-step production of waste cooking oil biodiesel>, Related Products of 112-63-0, the main research area is potassium hydroxide biodiesel waste cooking oil kinetic reactive distillation.

In this work, a novel method was proposed for the conversion of waste cooking oil into biodiesel. A two-step approach based on a pretreatment with AlCl3•6H2O to convert FFA into the relevant Me esters, followed by the complete transesterification of glycerides, under KOH catalysis in a reactive distillation column, was considered. The pretreatment with AlCl3•6H2O allowed to obtain two different phases: an oily phase, rich in FAME and triacylglycerols and with a very limited content of water (100 ppm), and residual FFA (1 mgKOH /goil), and a methanol phase, in which most of the catalyst, water and monoacylglycerols were dissolved in. The esterified stream was characterized by its composition and used to obtain new kinetic parameters to be used in the setting of the reactive distillation The reactive distillation column was proved to be efficient in obtaining a biodiesel stream with a purity requirement conform to the EN14214 standards The transesterification step was characterized by a sp. heating requirement of 701.3 kJ per kg of biodiesel produced.

Chemical Engineering and Processing published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics