Month: October 2022

Zhu, Yong-liang; Li, Shuang-long; Zhu, Chun-yang; Wang, Wan; Zuo, Wen-fei; Qiu, Xiang-jun published the artcile< Metabolomics analysis of the antidepressant prescription Danzhi Xiaoyao Powder in a rat model of Chronic Unpredictable Mild Stress (CUMS)>, Computed Properties of 112-63-0, the main research area is Danzhi Xiaoyao powder antidepressant mild stress; CUMS; Danzhi Xiaoyao powder; Depression; Metabolomics; UPLC/Q-TOF-MS.

Danzhi Xiaoyao Powder (DZXY) is a classical prescription, that has been extensively used in traditional Chinese medicine (TMC) to treat depression for many years. However, the mechanism of DZXY is still unclear. The aim was to investigate the mechanism of the antidepressant effect of DZXY on a rat model of chronic unpredictable mild stress (CUMS). Forty male SD (Sprague-Dawley) rats with similar open field test (OFT) results were randomLy divided into a control group (n = 10) and an exptl. group (n = 30). A depression model was established in the exptl. group using the CUMS method. After the CUMS model was established successfully, the rats were randomLy divided into a depression model group and a DZXY group. The DZXY group was fed DZXY, while the depression model group and control group were given an equal amount of 0.5% sodium CM-cellulose suspension. Intragastric administration was performed once daily for 14 consecutive days. Animal weight, the sugar preference test, the open field test and the forced swimming test were used to evaluate the modeling effect and the antidepressant effect of DZXY. After the experiment, the plasma of rats was collected and the changes in plasma metabolites were analyzed by UPLC/Q-TOF-MS. The UPLC/Q-TOF-MS spectra data were evaluated by pattern recognition anal. to determine the changes in endogenous metabolites in the rat plasma samples. The results of the behavioral investigation showed that the rat model of depression was successfully replicated and that DZXY had an antidepressant effect. Using the UPLC-MS/MS metabolomics platform, partial least squares (PLS) and orthogonal partial least squares (OPLS), metabolic profile models (R2 and Q2 ≥ 0.5) of rat plasma were successfully constructed. The model could distinguish among the control group, the depression model group and the DZXY group. Finally, 38 differential metabolites were identified in the plasma. According to KEGG (http://www.kegg.jp) pathway anal., amino acid metabolism, lipid metabolism, purine metabolism, the prolactin signaling pathway and bile secretion were enriched and represented the main metabolic pathways influenced in the plasma. This study successfully established a CUMS depression model. A total of 38 differential metabolites associated with depression were identified in the plasma of rats, 24 of which were modulated by DZXY. These results suggest that DZXY can improve excitability and play an antidepressant role by regulating phenylalanine metabolism, arachidonic acid metabolism, porphyrin metabolism, D-arginine and D-ornithine metabolism, steroid hormone biosynthesis, unsaturated fatty acid biosynthesis and steroid biosynthesis.

Journal of Ethnopharmacology published new progress about Antidepressants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hughes, Chambers C.; Kauffman, Christopher A.; Jensen, Paul R.; Fenical, William published the artcile< Structures, Reactivities, and Antibiotic Properties of the Marinopyrroles A-F>, Related Products of 252932-48-2, the main research area is antimicrobial antitumor marinopyrrole isolation preparation structure activity.

Cultivation of actinomycete strain CNQ-418, retrieved from a deep ocean sediment sample off the coast of La Jolla, CA, has provided marinopyrroles A-F. Sharing just 98% 16S rRNA gene sequence identity with S. sannurensis, the strain likely represents a new Streptomyces species. The metabolites contain an unusual 1,3′-bipyrrole core decorated with several chlorine and bromine substituents and possess marked antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The congested N,C-biaryl bond establishes an axis of chirality that, for marinopyrroles A-E, is configurationally stable at room temperature Moreover, the natural products are fashioned strictly in the M-configuration. The Paal-Knorr condensation was adapted for the synthesis of the 1,3′-bipyrrole core. Halogenation of this material with N-bromosuccinimide cleanly furnished the 4,4′,5,5′-tetrahalogenated core that characterizes this class of marine-derived metabolites.

Journal of Organic Chemistry published new progress about Actinobacteria. 252932-48-2 belongs to class esters-buliding-blocks, and the molecular formula is C7H10N2O2, Related Products of 252932-48-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Hao; Xie, Fei; Zhao, Zhang; Afsar, Noor Ul; Sheng, Fangmeng; Ge, Liang; Li, Xingya; Zhang, Xiwang; Xu, Tongwen published the artcile< Novel Poly(ester amide) Membranes with Tunable Crosslinked Structures for Nanofiltration>, Formula: C19H34O2, the main research area is polyester amide membrane tunable crosslinked nanofiltration; crosslinking density; desalination; dye/salt separation; interfacial polymerization; nanofiltration; poly(ester amide).

Tuning the crosslinking d. of interfacial-polymerized nanofiltration (NF) membranes varying from loose to dense structures can make them meet the demand of various applications. The properties (e.g., pore size and porosity) of NF membranes can be tuned by choosing monomers with different structures and reactivities. Herein, tris(hydroxymethyl)aminomethane (THAM), a low-cost and green monomer, is first employed for the preparation of poly(ester amide) (PEA) thin-film composite membranes via interfacial polymerization The moderate reactivity of THAM enables rational regulation of the crosslinking d. of PEA membranes from loose to dense structures by varying the THAM concentration, which can hardly be achieved for traditional polyamide or polyester membranes. The developed PEA membranes with a wide tunability range of crosslinking densities broaden their potential utility in NF. PEA membranes with dense structures show exceptional desalination performance with a water permeance of 11.1 L m-2 h-1 bar-1 and a Na2SO4 rejection of 97.1%. However, loose PEA membranes exhibit good dye/salt separation performance with a dye removal rate over 95.0% and negligible NaCl rejection (<7.5%), as well as high water permeance (>45 L m-2 h-1 bar-1). This work implies that PEA membranes with tunable crosslinked structures provide new possibilities for the development of task-specific separation membranes.

ACS Applied Materials & Interfaces published new progress about Antifouling agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meng, Lingqiao; Shi, Xingzhao; Zhang, Ruilong; Yan, Long; Liang, Zhaopeng; Nie, Yijing; Zhou, Zhiping; Hao, Tongfan published the artcile< Preparation and properties study of waterborne polyurethane synthesized by mixing polyester diols and isocyanates>, Formula: C19H34O2, the main research area is polyester diol isocyanate polymerization; waterborne polyurethane preparation.

In view of environmental protection requirements, it is an inevitable trend for waterborne coatings to replace traditional coatings. Waterborne polyurethane (WPU), a kind of typical resin used in coatings, has become a research hot topic of waterborne coatings because of its advantages, such as non-polluting, safe and reliable, excellent properties, good compatibility, and easy modification. In this article, solvent-free WPU is prepared by mixing 4,4′-dicyclohexylmethane diisocyanate/isophorone diisocyanate (HMDI/IPDI) and polycarbonate diol/ Polycaprolactone diol (PCDL/PCL). Through the comparison of the properties of the polymer, the best amount of raw materials was determined Specifically, R = 1.35 (R is NCO/OH ratio), the content of dimethylolpropionic acid (DMPA) is 5.5%, the content of trimethylol propane (TMP) is 2.5%, the mole ratio of HMDI/IPDI is 2:1, the mole ratio of PCDL/PCL is 2:1, and the preeminent WPU shows the excellent thermal stability, the contact angle of 118.04°, the hardness is H. The chem. structures and rough surface morphologies of the WPU films were characterized by FT-IR, TG, AFM, and SEM, resp. Therefore, considering the film properties, and the low cost, simple, and green process, this research will offer the possibility of application of this free-solvent WPU in industrial production and large-scale application.

Journal of Applied Polymer Science published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koppenhoefer, Bernhard; Allmendinger, Hans published the artcile< Derivatization reactions for enantiomer resolution of hydroxy acids by gas chromatography: a comparison of methods>, Application of C19H34O2, the main research area is derivatization hydroxy acid gas chromatog; enantiomer resolution gas chromatog derivatization; esterification enantiomer resolution gas chromatog.

Mandelic acid was converted to several derivatives that are resolved into enantiomers by gas chromatog. on the chiral stationary phase Chirasil-Val. Only the easily performed esterification by an alc. such as 3-pentanol, catalyzed by dry HCl, is satisfactory in terms of racemization, side-reactions, and chromatog. properties.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about Alcohols Role: USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Robins, Morris J.; Miranda, Karl; Rajwanshi, Vivek K.; Peterson, Matt A.; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan published the artcile< Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one Base and Nucleoside Derivatives>, Synthetic Route of 112-63-0, the main research area is cytotoxicity cyclization desilylation cross coupling ammonolysis nucleoside bicyclic furopyrimidinone; alkynyl furopyrimidinone bicyclic nucleoside kinase antiviral synthesis human cytomegalovirus.

Derivatives of the 2′-deoxynucleoside of furo[2,3-d]pyrimidin-2(3H)-one with long-chain alkyl (or 4-alkylphenyl) substituents at C6 exhibit remarkable anti-VZV (varicella-zoster virus) potency and selectivity, and analogous 2′,3′-dideoxynucleoside derivatives show anti-HCMV (human cytomegalovirus) activity. We now report a synthetic approach that enables the preparation of long-chain 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-ones, e.g. I, in which the rod-like acetylene spacer replaces the 4-substituted-Ph ring at C6 via desilylation, Cu-catalyzed 5-endo-Dig cyclization, cross-coupling, and ammonolysis reactions. Analogs with Me, β-D-ribofuranosyl, β-D-arabinofuranosyl, and 2-deoxy-β-D-erythro-pentofuranosyl substituents at N3 have been prepared Long-chain derivatives at C6 in the 2′-deoxynucleoside series showed virus-encoded nucleoside kinase-sensitive anti-VZV activity. Surprisingly, 3-methyl-6-(octyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one (prepared as a neg. anti-VZV test control) exhibited anti-HCMV activity, which supports the possibility of development of non-nucleoside anti-HCMV agents originating from uncomplicated derivatives of such bicyclic ring systems.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Qin; Law, Andy; Crowder, Michael W.; Geysen, H. Mario published the artcile< Homo-cysteinyl peptide inhibitors of the L1 metallo-β-lactamase, and SAR as determined by combinatorial library synthesis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is homocysteinyl peptide inhibitor metallo beta lactamase QSAR combinatorial library.

Homo-cysteinyl peptides were found to be more active than cysteinyl peptides toward L1 metallo-β-lactamase as reversible competitive inhibitors. A combinatorial library of more than 90 homo-cysteinyl peptides was synthesized and screened for their inhibitory activity toward the L1 enzyme. A systematic structure-activity relationship anal. has revealed the preferred interaction groups for L1 conserved binding sites of β-lactam substrates. The most active compound 95b, had a Ki of 2.1 nM.

Bioorganic & Medicinal Chemistry Letters published new progress about Combinatorial library. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guan, Yun; Pan, Mingyuan; Yang, Jun; Lu, Qiuxia; Han, Liangfu; Liu, Ying; Li, Jing; Zhu, Huaguang; Gong, Xiu; Mei, Guanghai; Liu, Xiaoxia; Pan, Li; Dai, Jiazhong; Wang, Yang; Wang, Enmin; Wang, Xin published the artcile< A phase II open label, single arm study of hypofractionated stereotactic radiotherapy with chemoradiotherapy using intensity-modulated radiotherapy for newly diagnosed glioblastoma after surgery: the HSCK-010 trial protocol>, HPLC of Formula: 112-63-0, the main research area is Adjuvant chemoradiotherapy; Hypofractionated stereotactic radiotherapy; Newly diagnosed glioblastoma.

Abstract: Background: The most frequently diagnosed primary brain tumor is glioblastoma (GBM). Nearly all patients experience tumor recurrence and up to 90% of which is local recurrence. Thus, increasing the therapeutic ratio of radiotherapy using hypofractionated stereotactic radiotherapy (HSRT) can reduce treatment time and may increase tumor control and improve survival. To evaluate the efficacy and toxicity of the combination of HSRT and intensity-modulated radiotherapy (IMRT) with temozolomide after surgery in GBM patients and provide evidence for further randomized controlled trials. Methods/design: HSCK-010 is an open-label, single-arm phase II trial (NCT04547621) which includes newly diagnosed GBM patients who underwent gross total resection. Patients will receive the combination of 30 Gy/5fx HSRT, and 20 Gy/10fx IMRT adjuvant therapy with concurrent temozolomide and adjuvant chemotherapy. The primary endpoint is overall survival (OS). Secondary outcomes include progression-free survival (PFS) rate, objective-response rate (ORR), quality of life (Qol) before and after the treatment, cognitive function before and after the treatment, and rate of treatment-related adverse events (AE). The combination of HSRT and IMRT with temozolomide can benefit the patients after surgery with good survival, acceptable toxicity, and reduced treatment time. Trial registration: NCT04547621. Registered on 14 Sept. 2020.

BMC Cancer published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kato, Kazuaki; Mizusawa, Tomoki; Ohara, Akihiro; Ito, Kohzo published the artcile< Direct enhancement of intercomponent interactions in polyrotaxane and its pronounced effects on glass state properties>, HPLC of Formula: 112-63-0, the main research area is enhancement intercomponent interaction polyrotaxane glass state polybutadiene cyclodextrin.

Strong interactions between the host cyclodextrin and the threading guest polymer were introduced by selective modifications to the polymer of a polybutadiene-based polyrotaxane. The changes in the intercomponent interactions influenced the mobility of the threading polymer that was confined in the glassy host framework, resulting in different mech. properties.

Chemical Communications (Cambridge, United Kingdom) published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fang, Fang; Wen, Wei-Bo; Xie, Xue-Hua; Yang, Ling; Zhang, Xu; Zhao, Jie published the artcile< The Mechanism of Jian-Gan-Xiao-Zhi Decoction in Insulin Resistant Adipocytes and Its Component Analysis>, Quality Control of 112-63-0, the main research area is Jian Gan hepatoprotectant adipocyte non alc fatty liver disease.

Jian-Gan-Xiao-Zhi decoction (JGXZ) is a traditional Chinese medicine formula to treat patients with non-alc. fatty liver disease (NAFLD). The study aimed to analyze the mechanism of JGXZ in adipocytes and detect the main components of the drug in rat serum. 3T3-L1 preadipocytes were used to establish an insulin resistant (IR) adipocyte model. Lipid accumulation in adipocytes was detected by oil red O staining. After JGXZ treatment, glucose consumption, total cholesterol (TC), and triglyceride (TG) were analyzed using the corresponding kits. ROS levels were measured by flow cytometry. In addition, Western blot was used to assess LKB1/AMPK and JNK/IRS/PI3k/AKT expressions. The main components of JGXZ in rat serum samples were detected by LC-MS/MS using a Phenomenex Luna C18 column, a mobile phase of methanol and 0.1% formic acid solution, and ESI detection. JGXZ significantly decreased glucose levels and adipogenesis, accompanied by decreased IR (P < 0.01). Besides, JGXZ markedly affected ROS, LKB1/AMPK, and JNK/IRS/PI3k/AKT levels (P < 0.01). R1, Rg1, paeoniflorin, Rb1, astragaloside IV, and tanshinone could be significantly quantified. JGXZ decreased glucose and lipid synthesis, possibly via the ROS/AMPK/JNK pathway. R1, Rg1, paeoniflorin, Rb1, astragaloside IV, and tanshinone in JGXZ could play major roles in treating NAFLD, which could assist in the study of the mechanism of JGXZ in treating NAFLD. Natural Product Communications published new progress about Adipocyte. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics