Month: October 2022

Paulo, Pedro M. R.; Laia, Cesar A. T.; Costa, Silvia M. B. published the artcile< Clusters in Polymer-Surfactant AOT Microemulsions Probed by Excited State Quenching Kinetics>, Formula: C19H34O2, the main research area is dynamics PEG bisethylhexyl sulfosuccinate surfactant cluster microemulsion quenching kinetics; fluorescence quenching laser flash photolysis dynamics polymer surfactant microemulsion.

Excited-state quenching kinetics were applied to sodium 1,4-bis(2-ethylhexyl)sulfosuccinate (AOT) reversed micelles with poly(oxy)ethylene (POE) of mol. weight 35 000 Da where clusters were previously detected [Laia, C. A. T., et al, 2000]. The data obtained in AOT reversed micelles, with a fixed value of the molar ratio of water to surfactant (w0 = [H2O]/[AOT]) w0 = 20, were compared in the absence and presence of the polymer. Two reaction time scales were studied with different probes: 1,3,6,8-pyrenetetrasulfonic acid (PTSA) in the nanosecond range and Cr(bpy)33+ in the microsecond range, using, resp., time-resolved fluorescence with picosecond resolution and laser flash photolysis techniques. The exptl. decays were analyzed assuming two components, one due to polymer-free micelles described by a Poisson distribution model kinetics and another associated with the polymer-induced micelle clusters, analyzed according to a model based on the concept of random walks in regular compact lattices. A step frequency, kw = 107 s-1, was extracted from the nanosecond results for the quencher’s random walk within the cluster. By contrast, the triplet absorption quenching studies did not distinguish between free micelles and clusters and afforded an aggregation number for the former in the range 260 ± 40, in good agreement with literature data. Decay simulations confirm the validity of the data treatment used in the nanosecond range, but the short time behavior predicted in the microsecond range was not observed within the equipment time resolution

Journal of Physical Chemistry B published new progress about Anionic surfactants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jablonowski, Jill A.; Grice, Cheryl A.; Chai, Wenying; Dvorak, Curt A.; Venable, Jennifer D.; Kwok, Annette K.; Ly, Kiev S.; Wei, Jianmei; Baker, Sherry M.; Desai, Pragyna J.; Jiang, Wen; Wilson, Sandy J.; Thurmond, Robin L.; Karlsson, Lars; Edwards, James P.; Lovenberg, Timothy W.; Carruthers, Nicholas I. published the artcile< The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists>, Quality Control of 112-63-0, the main research area is indole derivative preparation histamine H4 receptor antagonist structure activity.

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified a potential lead compound Investigation of the structure-activity relationship (SAR) resulted in the discovery of novel compounds, which are the first potent and selective histamine H4 receptor antagonists to be described.

Journal of Medicinal Chemistry published new progress about Antihistamines. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kelly, Martha J.; Pietranico-Cole, Sherrie; Larigan, J. Douglas; Haynes, Nancy-Ellen; Reynolds, Charles H.; Scott, Nathan; Vermeulen, John; Dvorozniak, Mark; Conde-Knape, Karin; Huang, Kuo-Sen; So, Sung-Sau; Thakkar, Kshitij; Qian, Yimin; Banner, Bruce; Mennona, Frank; Danzi, Sara; Klein, Irwin; Taub, Rebecca; Tilley, Jefferson published the artcile< Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tetrahydrotriazinecarbonitrile derivative MGL3196 thyroid hormone receptor agonist dyslipidemia treatment.

The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). A pyridazinone series has been identified that is significantly more THR-β selective than earlier analogs. Optimization of this series by the addition of a cyanoazauracil substituent improved both the potency and selectivity and led to MGL-3196 (53), which is 28-fold selective for THR-β over THR-α in a functional assay. Compound 53 showed outstanding safety in a rat heart model and was efficacious in a preclin. model at doses that showed no impact on the central thyroid axis. In reported studies in healthy volunteers, 53 exhibited an excellent safety profile and decreased LDL cholesterol (LDL-C) and triglycerides (TG) at once daily oral doses of 50 mg or higher given for 2 wk.

Journal of Medicinal Chemistry published new progress about Anticholesteremic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kakoee, Alireza; Gharehghani, Ayat; Mostafei, Mohsen published the artcile< Development of a reduced chemical kinetic mechanism for biodiesel/natural gas mixture>, Electric Literature of 112-63-0, the main research area is methyl palmitate heptane chem kinetics one dimensional model.

Biodiesel as an alternative fuel for diesel in compression ignition engines cab be used directly to this type of engine without any significant changes in geometry. Some neg. points of biodiesel in compression ignition (CI) engines such as high viscosity, injector carbonize and high NOx emissions cause to use this fuel with other fuels such as alc. fuels and natural gas based on desired properties of second fuel. Numerical study of fuels such as biodiesel needs to have a chem. kinetic mechanism that can predict combustion characteristics and output emissions. In this study, a reduced detailed mechanism of biodiesel introduced by Zhang et al. is chosen to merged with natural gas GRI-Mech 3.0 mechanism to obtain a chem. kinetic mechanism of biodiesel/natural gas. Direct relation graph with error propagation (DRGP) method and consequently sensitivity anal. was employed to 525 reactions and 126 species that modified with highly sensitive reactions. At first, reduced mechanism of biodiesel/natural gas compared with merged mechanism of these fuels’ mixture with 0-Dimension simulation of ignition delay and 1-Dimension simulation of flame speed. Obtained results show error less than 1% for all intake temperatures and equivalence ratios. In the following, the reduced mechanism with zero percent of natural gas compared with original biodiesel mechanism. Yet again, results show errors almost near zero in lower equivalence ratio and acceptable error, in maximum condition about 10%, in moderate and high equivalence ratios (ERs) during predicting ignition delay with 0-Dimension simulation. Also, flame speed in this evaluation shows less than 2% error in 1-Dimension simulation.

Fuel published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondo, Hiroki; Uno, Shingo; Moriuchi, Fumio; Sunamoto, Junzo; Ogushi, Susumu; Tsuru, Daisuke published the artcile< Synthesis and enzymatic carboxylation of a biotin-containing peptide representing the coenzyme binding site of E. coli acetyl-CoA carboxylase>, Electric Literature of 112-63-0, the main research area is acetyl CoA carboxylase biotin binding site; peptide biotin acetyl CoA carboxylase.

A biotin-containing pentapeptide, Boc-Glu-Ala-Met-Bct-Met (I) (where Boc = tert-butoxycarbonyl and Bct = N’-biotinyl-L-lysine), that corresponds to the coenzyme-binding site of Escherichia coli acetyl-CoA carboxylase (II) was prepared I, as well as free biotin, served as substrate for the carboxylation reaction catalyzed by the biotin carboxylase subunit dimer of E. coli II. The Km and Vmax values for I were 18 mM and 2.8 μM min-1, resp. The corresponding values for biotin were 214 mM and 28 μM min-1. Thus, the overall reactivity (Vmax/Km) of I exceeded that of biotin by 20%.

Bulletin of the Chemical Society of Japan published new progress about Escherichia coli. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lahner, Harald; Mathew, Annie; Klocker, Anna Lisa; Unger, Nicole; Theysohn, Jens; Rekowski, Jan; Joeckel, Karl-Heinz; Theurer, Sarah; Schmid, Kurt Werner; Herrmann, Ken; Fuehrer, Dagmar published the artcile< Streptozocin/5-fluorouracil chemotherapy of pancreatic neuroendocrine tumours in the era of targeted therapy>, Related Products of 112-63-0, the main research area is pancreatic neuroendocrine tumor streptozocin fluorouracil chemotherapy; 5-fluorouracil; Objective response; Pancreatic neuroendocrine tumor; Streptozocin; Survival.

The role of streptozocin-based chemotherapy (STZ CTx) in advanced, well-differentiated pancreatic neuroendocrine tumors (PanNET) and the best sequence of treatments in advanced PanNET are unclear. We examined the outcomes after STZ CTx in patients who had been selected according to the current therapeutic guidelines. Data from 50 PanNET patients consecutively treated with STZ CTx between 2010 and 2018 were analyzed. The endpoints of the study were the objective-response rate (ORR), progression-free survival (PFS), and overall survival (OS). STZ CTx was the first-line treatment in 54% of patients. The PanNET grades were as follows: 6% G1, 88% G2, and 6% well-differentiated G3. The ORR was 38%. Stable disease was the best response in 38% of patients and 24% showed progressive disease. Treatment was discontinued because of toxicity in one patient. Median PFS and OS were 12 (95% confidence interval (CI), 8.5-15.5) and 38 mo (95% CI, 20.4-55.6), resp. In the Kaplan-Meier anal., the median OS was 89 mo (95% CI, 34.9-143.1) for STZ CTx as first-line therapy compared with 22 mo (95% CI, 19.3-24.7; p = 0.001, log-rank test) for subsequent lines. Bone metastases neg. impacted survival (HR, 2.71, p = 0.009, univariate anal., HR, 2.64, p = 0.015, multivariate anal., and Cox regression). In patients selected according to current guidelines, PFS, and OS after STZ CTx were lower than previously reported, whereas ORR was unchanged. First-line treatment was pos. associated with OS and the presence of bone metastases was neg. associated with OS. Pre-treatment with targeted or peptide-receptor radionuclide therapy did not alter ORR, PFS, or OS.

Endocrine published new progress about Anemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simsek, Rahime; Linden, Anthony; Safak, Cihat published the artcile< (±)-9-(2-Bromophenyl)-7,7-dimethyl-1,3,4,5,6,7,8,9-octahydrofuro[3,4-b]quinoline-1,8-dione>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is mol structure bromophenyl methyl furoquinolinedione.

The title compound, C19H18BrNO3, has potential Ca modulatory properties. Crystallog. data are given. The 1,4-dihydropyridine ring has a very shallow boat conformation and is one of the most planar examples of this moiety. The 2-bromophenyl substituent is in the axial synperiplanar orientation. The quinoline ring has a half-chair conformation, with the unusual arrangement of the out-of-plane atom being on the opposite side of the ring plane to the bromophenyl substituent. The mols. are linked into chains by intermol. H bonds.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Seong Ri; Kim, Mi Ran; Jo, Eun Hae; Yoon, Keun-Byoung published the artcile< Synthesis of very low birefringence polymers using fluorinated macromers for polymeric waveguides>, Reference of 71195-85-2, the main research area is fluorinated macromer synthesis polymeric waveguide birefringence.

A series of highly fluorinated acrylic macromers and monomers containing perfluoroalkyl, perfluorophenyl, and perfluorocyclohexyl pendant groups were synthesized in an attempt at reducing absorption losses and birefringences. The macromers, prepared by the anionic polymerization of fluorinated acrylic monomers, were viscous liquids with number average mol. weights of 15,000-16,000 g mol-1. Macromer and monomer mixtures that generally exhibited viscosities suitable for the UV-imprint process were photopolymerized to prepare the polymeric films. At 850 nm, the films had very low birefringences (approx. 0.0001) and their refractive indexes (RIs) were linearly dependent on the mixture compositions; this allowed the RIs of films to be fine-tuned within at certain range. At 850 nm, the propagation losses of the multimode waveguides ranged from 0.12 dB cm-1 to 0.15 dB cm-1, demonstrating that these polymers are potentially useful as optically passive waveguide materials.

High Performance Polymers published new progress about Birefringence. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Correia, Jose Tiago M.; Acconcia, Lais V.; Coelho, Fernando published the artcile< Studies on Pumiliotoxin A Alkaloids: An Approach to Preparing the Indolizidinic Core by Intramolecular Diastereoselective N-Heterocyclic Carbene Catalyzed Benzoin Reaction>, Quality Control of 112-63-0, the main research area is pumiliotoxin A indolizidinic core preparation intramol diastereoselective benzoin; diastereoselective heterocyclic carbene catalyst benzoin reaction.

In this article, we describe the development of a convergent organocatalytic strategy to prepare the indolizidinic core I of the pumiliotoxin A alkaloid family. The key step of the proposed strategy is based on a diastereoselective N-heterocyclic carbene catalyzed benzoin reaction, in which the Breslow intermediate generated from an enal moiety in dicarbonyl compound II (umpolung a1 to d1 – acyl anion equivalent) attacks a ketone moiety intramolecularly to provide the indolizidinone core in good yield with good selectivity.

European Journal of Organic Chemistry published new progress about Benzoin condensation reaction (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vannoni, Lorenzo; Pizzimenti, Silvia; Caroti, Giulia; La Nasa, Jacopo; Duce, Celia; Bonaduce, Ilaria published the artcile< Disclosing the chemistry of oil curing by mass spectrometry using methyl linoleate as a model binder>, Quality Control of 112-63-0, the main research area is mass spectrometry methyl linoleate model binder oil curing.

The structure of the polymeric fraction in an oil painting is believed to be strongly connected to the stability of the paint layers over time, but its mol. characterization is extremely difficult given the complex composition of a vegetable oil-based polymer. In this study we report the implementation of a methodol. approach for the systematic mass spectrometric investigation of the mol. features of the products of oxidative degradation and crosslinking of oil paint layers upon curing. The approach is based on the use of Me linoleate as a simplified model of an oil paint binder. Gas-chromatog. coupled with mass spectrometry, solid phase microextraction gas chromatog. mass spectrometry, flow injection electrospray mass spectrometry and evolved gas anal. mass spectrometry, are used to analyze the evolution of compounds produced over seven months of natural ageing, from the volatile products to the macromol. and cross-linked fractions. The aim is to improve our fundamental mol. understanding of the curing process of oil paints, and to investigate the balance between oxidative degradation and crosslinking when specific binder-pigment combinations are in place. Model paint layers were prepared using lead white and ultramarine blue as pigments. These two pigments are known to produce paint layers with different stability over time. The use of Me linoleate as model oil binder greatly simplifies the mass spectral features of the lipid paint fraction, enabling the detection of products of oxidation and crosslinking with a new high level of mol. detail. Data clearly show that crucial differences between paints containing the two pigments establish with time, which are mostly related to the cross-linked fraction.

Microchemical Journal published new progress about Chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics