Month: October 2022

Josa-Cullere, Laia; Madden, Katrina S.; Cogswell, Thomas J.; Jackson, Thomas R.; Carter, Tom S.; Zhang, Douzi; Trevitt, Graham; Davies, Stephen G.; Vyas, Paresh; Wynne, Graham M.; Milne, Thomas A.; Russell, Angela J. published the artcile< A Phenotypic Screen Identifies a Compound Series That Induces Differentiation of Acute Myeloid Leukemia Cells In Vitro and Shows Antitumor Effects In Vivo>, Quality Control of 112-63-0, the main research area is imidazopyridine antitumor acute myeloid leukemia cell differentiation human.

Induction of differentiation is a promising therapeutic strategy against acute myeloid leukemia. However, current differentiation therapies are effective only to specific patient populations. To identify novel differentiation agents with wider efficacy, authors developed a phenotypic high-throughput screen with a range of genetically diverse cell lines. From the resulting hits, one chem. scaffold was optimized in terms of activity and physicochem. properties to yield OXS007417 I, a proof-of-concept tool compound, which was also able to decrease tumor volume in a murine in vivo xenograft model.

Journal of Medicinal Chemistry published new progress about Acute myeloid leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lei, Xiaoyun; Cui, Jiaxing; Wang, Shuqiang; Huang, Ting; Wu, Xiaoping published the artcile< Preparation of a biomimetic ionic liquids hybrid polyphosphorylcholine monolithic column for the high efficient capillary microextraction of glycopeptide antibiotics>, COA of Formula: C18H26O6, the main research area is capillary microextraction glycopeptide antibiotics; Biomimetic enrichment; Capillary microextraction; Glycopeptide antibiotics; Ionic liquids; Phosphorylcholine.

An ionic liquid hybrid zwitterionic polymer capillary microextraction (CME) column was prepared for the biomimetic enrichment of glycopeptides by one-step copolymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and 1-butyl-3-vinylimidazolium bromide, in the presence of crosslinker trimethylolpropane trimethacrylate (TMA). The resultant monolith was characterized by SEM (SEM), fourier transform IR (FT-IR) spectroscopy and pore size distribution measurement. Due to the incorporation of zwitterionic MPC owning a unique biomimic structure (i.e. hydrophilic cation/anion and hydrophobic long-alkyl chain), the monolithic column has large pore size and good biocompatibility, exhibiting high extraction efficiency, permeability and fast mass transfer to targets. Besides, the use of ionic liquids (ILs) as co-monomer in the polymerization endows the monolith with enhanced mech. stability, uniformity and multiple interactions. The prepared column was successfully applied in CME coupled to capillary electrochromatog. (CEC) for the efficient enrichment and separation of glycopeptide antibiotics in foodstuff. The method demonstrated a wide linear range (50.0-18000.0μg L-1), low detection limits (5.0-10.0μg L-1, S/N = 3) and satisfied recoveries (76.0-109.7%). This work shows the advantage of fine-tuning biomimetic monoliths in application-specific CME-CEC.

Journal of Chromatography A published new progress about Antibiotics. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, COA of Formula: C18H26O6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nagatomo, Akito; Kaneko, Yoshiro published the artcile< Sol-gel preparation of amphiphilic silsesquioxane containing ether-chain and ammonium groups capable of forming reverse micelles>, COA of Formula: C19H34O2, the main research area is soluble gel preparation amphiphilic silsequioxane reverse micelle hydrophilic dye.

In this study, we prepared an amphiphilic silsesquioxane (Am-SO) capable of forming reverse micelles. The synthesis was performed by the sol-gel reaction of a mixture of triethoxysilane containing an ether-chain and 3-aminopropyltrimethoxysilane in aqueous hydrochloric acid. The gel permeation chromatog. measurement of Am-SO in chloroform eluent (<1.0 w/v%) showed a correlation between the excluded volumes (mol. weights of the peak tops; Mp's) and concentrations, i.e., higher Mp's at higher concentrations On the contrary, the Mp's of Am-SQ in chloroform were constant at concentrations above 1.0 w/v%. These results indicated that Am-SQ could form reverse micelles at a relatively high concentration in chloroform. Furthermore, dynamic fight scattering measurements of the Am-SO chloroform solutions having various concentrations were performed. The average particle size (diameter) of the 0.5 w/v% Am-SQ solution was assessed to be 0.86 ± 0.13 nm, whereas those in the solutions above 1.0 w/v% concentration were 8-11 nm, indicating that Am-SQ afforded stable reverse micelles at concentrations above 1.0 w/v%. In addition, the reverse micelles of Am-SQ in chloroform could incorporate ionic hydrophilic dyes, such as tetraphenylporphine tetrasulfonic acid and 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt, as confirmed both visually and by UV-Vis spectroscopy. Journal of Nanoscience and Nanotechnology published new progress about Amphiphiles. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Planas, Oriol; Wang, Feng; Leutzsch, Markus; Cornella, Josep published the artcile< Fluorination of arylboronic esters enabled by bismuth redox catalysis>, Product Details of C19H34O2, the main research area is bismuth triarylbismuth oxidative addition reductive elimination fluorination catalyst; organoboron compound arylboronic acid fluorination substitution triarylbismuth complex catalyst; crystal structure triarylbismuth sulfinimide complex difluoride.

Triarylbismuth complexes undergo oxidative addition to yield difluorobismuth(V) derivatives, which, upon the reductive elimination provide a valuable route for catalytic fluorination of organoboron compounds Bismuth catalysis has traditionally relied on the Lewis acidic properties of the element in a fixed oxidation state. In this paper, we report a series of bismuth complexes that can undergo oxidative addition, reductive elimination, and transmetalation in a manner akin to transition metals. Rational ligand optimization featuring a sulfoximine moiety produced an active catalyst for the fluorination of aryl boronic esters through a bismuth (III)/bismuth (V) redox cycle. Crystallog. characterization of the different bismuth species involved, together with a mechanistic investigation of the carbon-fluorine bond-forming event, identified the crucial features that were combined to implement the full catalytic cycle.

Science (Washington, DC, United States) published new progress about Aryl fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xiao; Cai, Liang; Chen, Tao; Qiao, Jingyi; Zhang, Xiaosong published the artcile< Vapor-liquid equilibrium measurements and assessments of Low-GWP absorption working pairs (R32+DMETEG, R152a+DMETEG, and R161+DMETEG) for absorption refrigeration systems>, Reference of 112-63-0, the main research area is R32 R152a R161 DMETEG vapor liquid equilibrium absorption refrigeration.

This research aims to develop novel binary working pairs using low-GWP refrigerants (R32, R152a, or R161) and one chem. absorbent (DMETEG) for absorption refrigeration systems. The solubility data were determined from 293.15 to 343.15 K using a static method and were correlated with the five-parameter non-random two-liquid (NRTL) activity coefficient model with an average relative absolute error of <2.4%. All three binary mixtures exhibited neg. deviations from Raoult's law. DMETEG was further assessed with other organic solvents that were previously measured to verify its highest affinity with HFCs. Based on the obtained VLE data, the thermodn. performances in both the single-stage absorption refrigeration system (ARS) and the absorption-compression hybrid refrigeration system (ACHRS) were assessed. R161 yielded the highest cooling COP of 0.519-0.555 when the generation temperature was above 135°C, followed by the R152a at 0.231-0.518 when below 135°C. Different from the trends of COP variations, R152a had the highest ECOP of 0.091-0.158 when the generation temperature was below 135°C while R161 showed the highest ECOP of 0.116-0.137 over 135°C. ACHRS can effectively enhance the cooling performances of ARS via compression and its compression ratios got optimized. Overall, the R161 + DMETEG showed the best potential as the working pair. Energy (Oxford, United Kingdom) published new progress about Absorptive refrigeration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ciesluk, Mateusz; Piktel, Ewelina; Wnorowska, Urszula; Sklodowski, Karol; Kochanowicz, Jan; Kulakowska, Alina; Bucki, Robert; Pogoda, Katarzyna published the artcile< Substrate viscosity impairs temozolomide-mediated inhibition of glioblastoma cells′ growth>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Drug effectiveness; Glioblastoma; Polyacrylamide hydrogels; Rheology; Temozolomide; Viscoelasticity.

The mech. state of the extracellular environment of the brain cells considerably affects their phenotype during the development of central nervous system (CNS) pathologies, and when the cells respond to drugs. The reports on the evaluation of the viscoelastic properties of different brain tumors have shown that both tissue stiffness and viscosity can be altered during cancer development. Although a compelling number of reports established the role of substrate stiffness on the proliferation, motility, and drug sensitivity of brain cancer cells, there is a lack of parallel data in terms of alterations in substrate viscosity. Based on viscoelasticity measurements of rat brain samples using strain rheometry, polyacrylamide (PAA) hydrogels mimicking elastic and viscous parameters of the tissues were prepared Optical microscopy and flow cytometry were employed to assess the differences in glioblastoma cells morphol., proliferation, and cytotoxicity of anticancer drug temozolomide (TMZ) due to increased substrate viscosity. Our results indicate that changes in substrate viscosity affect the proliferation of untreated glioma cells to a lesser extent, but have a significant impact on the apoptosis-associated depolarization of mitochondria and level of DNA fragmentation. This suggests that viscosity sensing and stiffness sensing machinery can activate different signaling pathways in glioma cells. Collected data indicate that viscosity should be considered an important parameter in in vitro polymer-based cell culture systems used for drug screening.

Biochimica et Biophysica Acta, Molecular Basis of Disease published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Peng-Yang; Huang, Chen-Yang; Li, Jia-Wun; Shen, Sheng-Yen; Cheng, Chih-Chia; Chiu, Chih-Wei; Jeng, Ru-Jong; Lin, Jiang-Jen published the artcile< Immobilization of Air-Stable Copper Nanoparticles on Graphene Oxide Flexible Hybrid Films for Smart Clothes>, Application of C19H34O2, the main research area is graphene oxide copper film nanoparticle immobilization anti oxidation property; copper nanoparticles; electrical conductivity; electrocardiogram; graphene oxide; nanohybrids; polymeric dispersant; smart clothes.

Through the use of organic/inorganic hybrid dispersants-which are composed of polymeric dispersant and two-dimension nanomaterial graphene oxide (GO)-copper nanoparticles (CuNPs) were found to exhibit nano stability, air-stable characteristics, as well as long-term conductive stability. The polymeric dispersant consists of branched poly(oxyethylene)-segmented esters of trimellitic anhydride adduct (polyethylene glycol-trimethylolpropane-trimellitic anhydride, designated as PTT). PTT acts as a stabilizer for CuNPs, which are synthesized via in situ polymerization and redox reaction of the precursor Cu(CH3COO)2 within an aqueous system, and use graphene oxide to avoid the reduction reaction of CuNPs. The results show that after 30 days of storage the CuNPs/PTT/GO composite film maintains a highly conductive network (9.06 x 10-1 Ω/sq). These results indicate that organic/inorganic PTT/GO hybrid dispersants can effectively maintain the conductivity stability of CuNPs and address the problem of CuNP oxidation Finally, the new CuNPs/PTT/GO composite film was applied to the ECG (ECG) smart clothes. This way, a stable and antioxidant-sensing electrode can be produced, which is expected to serve as a long-term ECG monitoring device.

Polymers (Basel, Switzerland) published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Fei; Chen, Xiang-Yu; Ye, Song published the artcile< [3 + 4] Annulation of Bromoenals and 1,2-Benzenedithiol: Base-Promoted [2 + 4] Reaction and N-Heterocyclic Carbene-Catalyzed Ring-Expansion>, Quality Control of 112-63-0, the main research area is benzo dithiepinone preparation bromoenal benzenedithiol heterocyclic carbene catalyzed annulation; benzodithiine preparation bromoenal benzenedithiol ring expansion.

The [3 + 4] and [2 + 4] annulations of bromoenals and 1,2-benzenedithiol were developed in the presence or absence of N-heterocyclic carbene, resp. Control experiment and kinetic investigation revealed the [3 + 4] annulation involves the base-promoted [2 + 4] annulation and the following carbene-catalyzed ring-expansion.

Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction (catalysts). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dolby, Jorgen; Dahlbom, Richard; Hasselgren, Karl H.; Nilsson, J. L. G. published the artcile< Bicyclic enamines. I. Rearrangement of a quaternary quinuclidine-3-carboxylic acid ester and total synthesis of gentianadine>, COA of Formula: C8H9NO2, the main research area is quinuclidinecarboxylic rearrangement; gentianadine alkaloid preparation; nicotinic lactone; enamines bicyclic.

Me 2,3-didehydroquinuclidine-3-carboxylate methiodide loses MeI and is rearranged to 4-(2-hydroxyethyl)-1-methyl-1,4,5,6-tetrahydronicotinic acid lactone when heated without solvent to its m.p. The structure of the lactone was confirmed by an independent synthesis which also involved the total synthesis of the alkaloid gentianadine.

Acta Chemica Scandinavica (1947-1973) published new progress about Rearrangement. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, COA of Formula: C8H9NO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cheng, Yunlei; Cao, Youming published the artcile< Synthesis of imine carboxylic acid chelating resin>, COA of Formula: C19H34O2, the main research area is bromostyrene divinylbenzene copolymer diethyl iminodiacetate reaction chelating resin synthesis.

An imine carboxylic acid chelating resin was synthesized via suspension polymerization with 1, 2-divinyl benzene (o-DVB) and iminodiacetic acid di-Et ester as feedstock, polyethylene glycol as emulsifier, NaCl water solution as dispersed phase, and toluene as oil phase solvent. The functional group and morphol. of the product were characterized, and the impact of bromide time, initiator, mole ratio of feedstock on yield of brominated polystyrene were observed as well. The yield of brominated polystyrene increases and then decreases with the increasing of bromide time, and the optimal bromide time is 45 min; it also surges then drops slightly with the initiator increasing and reaches the peak of 72% when the initiator is 0.18 g; the yield of the product follows the increasing of the mole ratio of o-DVB and brominated DVB, while the destiny of functional group is decreased. There the more the initiator are, the smaller the particle of brominated polystyrene becomes, and the greater granulation rate achieves.

Hecheng Shuzhi Ji Suliao published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics