Month: October 2022

Nunez-Briones, A. G.; Benavides, R.; Mendoza-Mendoza, E.; Martinez-Pardo, M. E.; Carrasco-Abrego, H.; Kotzian, C.; Saucedo-Zendejo, F. R.; Garcia-Cerda, L. A. published the artcile< Preparation of PVC/Bi2O3 composites and their evaluation as low energy X-Ray radiation shielding>, Formula: C18H26O6, the main research area is polyvinyl chloride bismuth oxide composite radiation shielding.

Plasticized and gamma crosslinked PVC composites were prepared by adding different amounts of Bi2O3 particles to evaluate their low energy X-ray radiation shielding properties. Composites were gamma-irradiated in an industrial irradiator (60Co source) at the corresponding times to obtain a dose of 75 kGy to enhance mech. properties through crosslinking. The shielding properties of composites were obtained by X-ray transmission measurements at low energies (X-ray tube voltages range 20-61 kV) by using a mammog. unit and an X-ray hospital equipment. A small influence in the dehydroclorination reaction of PVC was observed during decomposition in TGA experiments due to Bi2O3 nanoparticle content, but DMA results show improved viscoelastic properties for the crosslinked composites. The X-ray transmission values decrease as a function of nanoparticle content, observing an increase in the transmission values (low attenuation) at higher energies. The composite with 50wt.% of Bi2O3 showed the lowest transmission values, at X-ray tube voltages 20-30 kV, the transmittance was almost nil, and then it increases ∼27% at 61 kV.

Radiation Physics and Chemistry published new progress about Complex modulus, tan δ. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Formula: C18H26O6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kikalishvili, T. J.; Kereselidze, J. A. published the artcile< Trimeric mechanism of proton transfer in imidazole>, Formula: C19H34O2, the main research area is imidazole derivative proton transfer trimeric mechanism AM1 MO.

The energy, electronic, and structural characteristics of the tautomeric transformation of imidazole were calculated by the quantum-chem. semiempirical AM1 method. It was concluded on the basis of the calculated data that proton transfer in the tautomeric transformation 1H-imidazole ⇄ 3H-imidazole can take place by a trimeric mechanism.

Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about Potential energy surface (proton transfer). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Numao, Naganori; Hamada, Tatsuo; Yonemitsu, Osamu published the artcile< A mechanistic study of the photoreaction of dimethylaniline and methyl chloroacetate. Role of acid-base properties in both the ground state and the excited state>, Product Details of C9H9NO4, the main research area is fluorescence quenching alkylation dimethylaniline; methoxycarbonylmethylation aniline photochem mechanism; exciplex dimethylaniline photochem methoxycarbonylmethylation; kinetics photochem methoxycarbonylmethylation methylaniline.

Quantum yields for fluorescence quenching and disappearance of PhNMe2 (I) were determined for the photochem. alkylation of I with ClCH2CO2Me, in both acidic and basic solutions, to give o- and p-MeO2CCH2C6H4NMe2. Under acidic conditions the reaction occurs via an exciplex, and under basic conditions an exciplex and a charge-transfer complex are involved.

Tetrahedron published new progress about 30095-98-8. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jang, Keun Sam; Shin, Dong Seok; Srisook, Ekaruth; Song, Ho-Chun; Chi, Dae Yoon published the artcile< Versatile functionalization of electron rich-fused heterocyclic arenes via electrophilic aromatic addition reaction and their applications>, SDS of cas: 112-63-0, the main research area is methoxyquinaldine regioselective bromomethoxylation; bromo alkoxyquinaldine preparation; dibromo dimethoxydihydroquinaldine amine regioselective nucleophilic substitution reaction; amino bromo methoxyyquinaldine preparation.

Divergent functionalized 8-methoxyquinaldines were synthesized via regioselective debromination, 1,3-bromine shift process, aromatization with treatment of a strong base, nucleophilic substitution reaction at the C7 position using amines and cyanide as a nucleophile in the absence of a metal source and a catalyst from an unusual electrophilic aromatic addition (AdEAr) reaction products. In addition, quinaldine-7,8-dione was prepared by presence of CAN (ceric ammonium nitrate) in AcOH and H2O for 10 min at room temperature from N-(alkylamino)-8-methoxyquinalidines. During the AdEAr reaction, new stereoselective dearomatized addition products were generated via discriminative reaction routes depending on the methoxy and bromine occupancy position. The AdEAr reaction not only allowed for the functionalization of electron rich-fused heterocyclic arenes, but also provided a new synthetic route to an alternative mechanism for electrophilic aromatic substitution reactions.

Tetrahedron published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nishikawa, Toshio; Urabe, Daisuke; Yoshida, Kazumasa; Iwabuchi, Tomoko; Asai, Masanori; Isobe, Minoru published the artcile< Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analogue of Puffer Fish Toxin>, SDS of cas: 112-63-0, the main research area is asym synthesis deoxytetrodotoxin analog Puffer fish toxin synthon.

8,11-Dideoxytetrodotoxin, an unnatural tetrodotoxin analog, was synthesized in a highly stereoselective manner from a common intermediate in our synthetic studies on tetrodotoxin. The synthesis features neighboring group participation of trichloroacetamide for stereoselective hydroxylation, protection of ortho ester, and guanidine installation with Boc-protected isothiourea.

Organic Letters published new progress about Hydroxylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Henrot, Serge; Larcheveque, Marc; Petit, Yves published the artcile< Amino acids as chiral synthons: preparation of enantiomerically pure (R)- and (S)-malic acids and its application to the synthesis of 3-hydroxy-4-butanolide>, Related Products of 617-55-0, the main research area is aspartic acid deamination nitrous acid; malic acid conversion hydroxybutanolide; enantiomeric purity hydroxybutanolide malic acid; amino acid chiral synthon.

Nitrous acid deamination of (S)-aspartic acid gave (S)-malic acid, which dissolved in AcCl to give anhydride I. Reaction of I with MeOH gave the half ester which was chemoselectively reduced by borohydride to hydroxybutanolide II of high optical purity.

Synthetic Communications published new progress about Chiral synthons. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Related Products of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khan, Anowar H.; Cook, Jeffery K.; Wortmann, Wayne J. III; Kersker, Nathan D.; Rao, Asha; Pojman, John A.; Melvin, Adam T. published the artcile< Synthesis and characterization of thiol-acrylate hydrogels using a base-catalyzed Michael addition for 3D cell culture applications>, Reference of 112-63-0, the main research area is thiol acrylate hydrogel Michael addition 3D cell culture.

There is significant interest in developing new approaches for culturing mammalian cells in a three-dimensional (3D) environment due to the fact that it better recapitulates the in vivo environment. The goal of this work was to develop thiol-acrylate, biodegradable hydrogels that possess highly tunable properties to support in vitro 3D culture. Six different hydrogel formulations were synthesized using two readily available monomers, a trithiol (ETTMP 1300 [ethoxylated trimethylolpropane tri(3-mercaptopropionate) 1300]) and a diacrylate (PEGDA 700 [polyethylene glycol diacrylate 700]), polymerized by a base-catalyzed Michael addition reaction. The resultant hydrogels were homogeneous, hydrophilic, and biodegradable. Different mech. properties such as gelation time, storage modulus (or the elasticity G’), swelling ratio, and rate of degradation were tuned by varying the weight percentage of polymer, the molar ratio of thiol-to-acrylate groups, and the pH of the solution Cytocompatibility was assessed using two model breast cancer cell lines by both 2D and 3D cell culturing approaches. The hydrogel formulations with a thiol-to-acrylate molar ratio of 1.05 were found to be optimal for both 2D and 3D cultures with MDA-MB-231 cellular aggregates found to be viable after 17 days of 3D continuous culture. Finally, MCF7 cells were observed to form 3D spheroids up to 600μm in diameter as proof of principle for the thiol-acrylate hydrogel to function as a scaffold for in vitro 3D cell culture. A comparison of the different mech. properties of the six hydrogel formulations coupled with in vitro cell culture results and findings from previously published hydrogels conclude that the thiol-acrylate hydrogels have significant potential as a scaffold for 3D cell culture.

Journal of Biomedical Materials Research, Part B: Applied Biomaterials published new progress about Animal tissue culture. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ito, Kenji; Chuang, Jeffrey; Alvarez-Lorenzo, Carmen; Watanabe, Tsuyoshi; Ando, Nozomi; Grosberg, Alexander Yu. published the artcile< Multiple-contact adsorption of target molecules by heteropolymer gels>, Electric Literature of 112-63-0, the main research area is thermal sensitive isopropylacrylamide copolymer gel adsorption.

We examined adsorption of target mols. through a multiple-contact interaction in a thermo-sensitive heteropolymer gel which can undergo a volume transition at 34 °C in water. Multi-valent anionic target mols. were adsorbed electrostatically by monovalent cationic adsorbing sites in the gel. The overall affinity (SK) between the gel and the target mol. was calculated from the initial slope of the Langmuir adsorption isotherm: [Tads] = KS[Tsol]/(1 + K[Tsol]), where S, K, [Tsol] and [Tads] represent the number of adsorption sites per unit volume of the gel, the effective binding constant, the equilibrium target concentration in the external solution, and the target concentration adsorbed in the gel, resp. The affinity for the collapsed gel at 60° was studied in terms of the concentrations of three factors: the adsorber, the coexistent salt, and the cross-linker. We found that the relationship between the affinity and these factors can be summarized by an equation first suggested by T. Tanaka.

Macromolecular Symposia published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dai, Weimin; Wu, An; Li, Yunping; Yu, Guofeng; Yan, Xinjiang published the artcile< XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair.>, Application In Synthesis of 112-63-0, the main research area is XPA; glioblastoma; nucleotide excision repair; temozolomide.

Glioblastoma is the most frequent, as well as aggressive kind of high-grade malignant glioma. Chemoresistance is posing a significant clinical barrier to the efficacy of temozolomide-based glioblastoma treatment. By suppressing xeroderma pigmentosum group A (XPA), a pivotal DNA damage recognition protein implicated in nucleotide excision repair (NER), we devised a novel method to enhance glioblastoma therapy and alleviate temozolomide resistance. On the basis of preliminary assessment, we found that XPA dramatically increased in glioblastoma compared with normal cells and contributed to temozolomide resistance. By constructing XPA stably knockdown cells, we illustrate that XPA protects glioma cells from temozolomide-triggered reproductive cell death, apoptosis, as well as DNA repair. Besides, XPA silencing remarkably enhances temozolomide efficacy in vivo. This study revealed a crucial function of XPA-dependent NER in the resistance of glioma cells to temozolomide.

Cell transplantation published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abdel Karim, M.; Sima, A.; Mekki, Mai published the artcile< Chemical constituents and antimicrobial activity of sudanese lagenaria siceraria standley (Cucurbitaceae) Oil>, Application In Synthesis of 112-63-0, the main research area is Cucurbitaceae oil sudanese lagenaria siceraria standley antimicrobial activity.

In this study, the constituents and antimicrobial activity of Lagenaria siceraria oil. have been investigated. Lagenaria sicerariaStandley is a common fruit vegetable in the family Cucurbitaceae. The fruit has many uses in ethnomedicine. Fruit is used as diuretic, immunosuppressant, cardio-protective and cardio-tonic. Lagenaria siceraria possesses antioxidant, hypolipidemic and hepatoprotective properties. GC- MS anal. of Lagenaria siceraria oil revealed the presence of three major constituents: linoleic acid Et ester (57.96%); 9,12-octadecenoic acid Me ester (19.56%) and hexdecanoic acid (10.15%%). The oil was screened for antimicrobial activity against five standard human pathogens by using the paper disk diffusion method. The oil showed moderate activity against Pseudomonas aeruginosa.

Pharmaceutical and Chemical Journal published new progress about Acetoxymethyl esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics